Spotting Conglomerates by Second Harmonic Generation

Galland, A.; Dupray, Valérie; Berton, Benjamin; Sanselme, Morgane; Atmani, H.; Coquerel, Gérard

doi:10.1021/cg801356m

Cited by 67 publications

(71 citation statements)

References 29 publications

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“…Several different situations can be contemplated: -The racemic compound lattice can be non centrosymmetric and non chiral. That is to say the space group belongs to one of the following symmetry classes: m, mm2, -4, 4mm, -42m, 3m, -6, 6mm, -6m2, -43m [2]. -…”

Section: Discussionmentioning

confidence: 99%

“…However, one can not conclude that the 4 other salts are not conglomerates. Indeed, in this study, the possibilities of polymorphism or efflorescent solvate were not investigated [2]. The separation of enantiomers by preferential crystallization is possible only if the racemic mixture crystallizes as a conglomerate.…”

Section: X-ray Powder Diffraction Analysesmentioning

confidence: 98%

“…Recently, the potential of Second Harmonic Generation (SHG) for conglomerate detection was investigated [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advanced prototype using second harmonic generation (SHG) for pre-screening of conglomerates

Galland

Dureisseix²,

Mahieux³

et al. 2009

XXXV JEEP – 35th Conference on Phase Equilibria

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Abstract:Up to know, the enantiomers of component A (a chiral intermediate schematized in figure 1) have been separated by means of chiral chromatography. A less expensive method applicable to industrial production was requested. The resolution by preferential crystallization, which requires a stable conglomerate, could be one of the alternative routes. In this study, the screening of potential conglomerates was performed by using the Second Harmonic Generation (SHG). Among the 109 crystallization attempts with different counter ions and solvents, 51 crystalline salts were obtained; a single conglomerate-forming system has been detected (with sulfamic acid). Resolution by means of preferential crystallization has been achieved with this salt. This paper underlines the potential of SHG method as a pre high throughput technique for spotting chiral discrimination in the solid state.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: X-ray Powder Diffraction Analysesmentioning

confidence: 98%

See 1 more Smart Citation

Advanced prototype using second harmonic generation (SHG) for pre-screening of conglomerates

Galland

Dureisseix²,

Mahieux³

et al. 2009

XXXV JEEP – 35th Conference on Phase Equilibria

View full text Add to dashboard Cite

show abstract

“…For the system studied, the SHG activity of the powder samples obtained for different compositions was measured using the Kurtz and Perry method with the experimental setup previously described by Galland et al [3] Binary phase diagram were constructed by using DSC and XRPD.…”

Section: Methodsmentioning

confidence: 99%

“…The second harmonic generation efficiency of a given material depends mainly on (i) the intrinsic crystallographic features of the phase, (ii) the orientation of the crystal(s) (crystallographic axes) with reference to the fundamental beam orientation and polarization, (iii) the crystal size distribution. SHG was formerly proposed as a rapid, reliable and very sensitive test of non-centrosymmetry for powdered crystalline compounds [2] with applications to structure assignments and pre-screening of conglomerates [3]. It was also proposed as an efficient technique for the quantification of a crystalline phase inside an amorphous matrix [4] and, recently, we demonstrated that SHG can be used to assess the structural purity of an organic compound down to the ppm level [5].…”

Section: Introductionmentioning

confidence: 99%