Spotted Fever Group Rickettsiae in Inner Mongolia, China, 2015–2016

Yin, Xuhong; Guo, Shengchun; Ding, Chunlian; Cao, Minzhi; Kawabata, Hiroki; Sato, Kozue; Ando, Shuji; Fujita, Hiromi; Kawamori, Fumihiko; Su, Hongru; Shimada, Masahiko; Shimamura, Yuko; Masuda, S.; Ohashi, Norio

doi:10.3201/eid2411.162094

Cited by 29 publications

(20 citation statements)

References 9 publications

(12 reference statements)

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“…A previous study indicated the A. bovis infection of monkeys, suggesting that A. bovis may infect humans [ 46 ]. Rickettsia japonica , which was widely distributed in China (including in Henan [ 40 ], Anhui [ 7 ], Zhejiang [ 47 ], Shandong [ 48 ], and Hubei [ 26 ]) and R. raoultii , which was mainly reported around the border of China (like the Northeastern [ 49 ], Northwestern [ 50 , 51 ], Southwestern [ 52 ], Inner Mongolia [ 53 ], and Central [ 40 ] areas) belonged to the spotted fever group rickettsiae and could cause human fever, vomiting, nausea, maculopapular rash, and occasionally eschars at the site of inoculation [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China

et al. 2021

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Tickborne intracellular bacterial pathogens including Anaplasma, Coxiella burnetti, Ehrlichia, and Rickettsia cause emerging infectious diseases worldwide. PCR was used to amplify the genes of these pathogens in Haemaphysalis flava ticks collected from hedgehogs in Central China. Among 125 samples including 20 egg batches, 24 engorged females, and 81 molted male and female adult ticks, the DNA sequences and phylogenetic analysis showed that the minimum infection rate of the ticks was 4% (5/125) for A. bovis, 3.2% (4/125) for C. burnetti, 9.6%, (12/125) for E. ewingii, and 5.6% for Rickettsia including R.japonica (3.2%, 4/125) and R. raoultii (2.4%, 3/125), respectively. The prevalence of these pathogens was significantly higher in dead engorged females (83.3%, 20/24) than in eggs (5%, 1/20) and molted ticks (8.6%, 7/81). Our study indicated that H. flava ticks could be infected with multiple species of tickborne pathogens including Anaplasma, C. burnetti, Ehrlichia, and Rickettsia in Central China, and the prevalence of these pathogens was reduced during transovarial and transstadial transmission in ticks, suggesting that ticks may not be real reservoirs but only vectors for these tickborne pathogens.

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Section: Discussionmentioning

confidence: 99%

Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China

et al. 2021

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“…In China, R. raoultii infection cases with increasing numbers have been reported in humans [17][18][19]29]. These rickettsiose patients present not only lethargy, fever, and headache, but also neurological abnormalities [19].…”

Section: Discussionmentioning

confidence: 99%

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Jian

Moumouni

et al. 2020

Pathogens

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The Qinghai-Tibetan Plateau Area (QTPA) is a plateau with the highest average altitude, located in Northwestern China. There is a risk for interspecies disease transmission, such as spotted fever rickettsioses. However, information on the molecular characteristics of the spotted fever group (SFG) Rickettsia spp. in the area is limited. This study performed screenings, and detected the DNA of human pathogen, SFG Rickettsia spp., with 11.3% (25/222) infection rates in yaks (Bos grunniens). BLASTn analysis revealed that the Rickettsia sequences obtained shared 94.3–100% identity with isolates of Rickettsia spp. from ticks in China. One Rickettsia sequence (MN536161) had 100% nucleotide identity to two R. raoultii isolates from Chinese Homo sapiens, and one isolate from Qinghai Dermacentor silvarum. Meanwhile, another Rickettsia sequence (MN536157) shared 99.1–99.5% identity to one isolate from Dermacentor spp. in China. Furthermore, the phylogenetic analysis of SFG Rickettsia spp. ompA gene revealed that these two sequences obtained from yaks in the present study grouped with the R. slovaca and R. raoultii clades with isolates identified from Dermacentor spp. and Homo sapiens. Our findings showed the first evidence of human pathogen DNA, SFG Rickettsia spp., from animals, in the QTPA.

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“…It is parasitic on livestock and can also cause damage to humans [29]. D.nuttalli can carry different pathogens including Babesia, Anaplasma vois, Rickettsia, and Coxellia [30,31,32]. I. persuleatus is the dominant tick species in northeast China.…”

Section: Discussionmentioning

confidence: 99%

Microbial Diversity of Ticks And A Novel Tyhpus Group Rickettsia Species ( R. bacterium Ac37b) Detected In Inner Mongolia, China

Ling

Gui

et al. 2021

Preprint

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Background: Ticks are arthropods that can carry multiple pathogens and parasitize on livestock and mammals as well as on humans. Animal husbandry in Inner Mongolia, China, provides a suitable tick habitat. In this study, PacBio full-length 16S rDNA third-generation sequencing was used to analyze the diversity of microbial communities carried by ticks in different regions of Inner Mongolia. The aim of the study is to characterize the microbiome carried by ticks in different geographical locations and to provide theoretical support for regional prevention and control of pathogen populations in the future. Methods: In this study, a total of 905 Dermacentor nuttalli and 36 Ixodes persuleatus were collected from the surface of sheep in four main pasture areas in Inner Mongolia. Pooled DNA samples were prepared from three samples from each region and from each tick species. In total the microbial diversity of 12 samples was analyzed by PacBio full-length 16S rRNA third-generation sequencing, and the α and β diversity were determined. Results: The main bacterial genera we found were Rickettsia (35.27%), Ac37b (19.33%), Arsenophonus (11.21%), Candidatus Lariskella (10.84%), and Acinetobacter (7.17%). There were significant differences in the microbial composition of ticks from different regions and in different tick species. Rickettsia bellii was found in the I. persuleatus group. In addition, Anaplasma and a novel tyhpus group Rickettsia species (R. bacterium Ac37b) were found in the sample group of D. nuttalli in the city of Ordos.Conclusions: In this study, Rickettsia bellii was first found in I. persuleatus in Inner Mongolia, and a novel tyhpus group Rickettsia species (R. bacterium Ac37b) was found in D. nuttalli from the city of Ordos. Our study provides a basis for the prevention and control of tick-borne diseases through the analysis of tick microbial diversity in different regions of Inner Mongolia. Furthermore, we were able to detect a new tick-borne pathogen in D. nutalli.

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Spotted Fever Group Rickettsiae in Inner Mongolia, China, 2015–2016

Cited by 29 publications

References 9 publications

Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China

Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China

Human Spotted Fever Group Rickettsia Infecting Yaks (Bos grunniens) in the Qinghai-Tibetan Plateau Area

Microbial Diversity of Ticks And A Novel Tyhpus Group Rickettsia Species ( R. bacterium Ac37b) Detected In Inner Mongolia, China

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