Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia
Souraya Rammal,
Warde Semaan,
Natalia Aprahamian
et al.
Abstract:Mutated or unmutated immunoglobulin heavy chain (IGHV) gene is an important prognostic factor in chronic lymphocytic leukemia (CLL). However, a small fraction of patients with CLL are classified as borderline (BL)-IGHV. Few data are available on this subgroup of CLL. In this paper, we retrospectively report and analyze data from 21 patients with BL-IGHV CLL, showing the heterogeneity of this subgroup of CLL and paving the way for more research focusing on this entity to optimize the management and treatment of… Show more
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