Spotlight on avian pathology: fowl adenovirus (FAdV) in chickens and beyond – an unresolved host-pathogen interplay

Schachner, Anna; Grafl, Beatrice; Heß, Michael

doi:10.1080/03079457.2020.1810629

Cited by 30 publications

(26 citation statements)

References 29 publications

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“…In fact, it is not uncommon to isolate multiple heterologous strains from a single bird harbouring high levels of neutralizing antibodies against a single serotype due to lack of cross-protectivity (Hess, 2020). In that aspect, regular monitoring of antibodies against specific serotypes in parental birds before the onset of egg production would likely help formulate protection strategies (Schachner et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of fowl adenovirus (FAdV) infections in South Korean chickens during 2013–2019 following introduction of FAdV-4 vaccines

Lai¹,

Min

Lai

et al. 2021

Avian Pathology

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Fowl adenoviruses (FAdV) are important infectious pathogens responsible for causing substantial economic losses to the poultry industry worldwide. One hundred and forty-six FAdV strains were continuously collected and analysed from 2013 to 2019 to understand the epidemiological change and nature of the virus in South Korea from two different standpoints, before and after the release of multiple commercial FAdV-4 vaccines. Phylogenetic analysis of the hexon loop-1 gene sequences showed that 92 strains belonged to FAdV-C (63%), 35 strains to FAdV-E (24%), 18 strains to FAdV-D (12.3%), and one strain to FAdV-A (0.7%), respectively. We provide evidence that the dominant FAdV serotype has recently changed from FAdV-4 to FAdV-8b, as reflected in the proportion of each serotype in field cases in 2019 (18.5% and 77.8%, respectively). The newly emerged FAdV-8b cluster was significantly noticeable compared to the old FAdV clusters, indicating that the development of a vaccine for FAdV-8b may be necessary. Overall, this new insight into FAdV prevalence provides a foundation for strategic control and the development of efficient vaccines against FAdV cases in chickens in South Korea. RESEARCH HIGHLIGHTS. The dominant FAdV serotype in South Korea shifted from FAdV-4 to FAdV-8b in 2013-2019. . A new cluster of FAdV-8b has emerged in South Korea, indicating the development of new vaccines.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of fowl adenovirus (FAdV) infections in South Korean chickens during 2013–2019 following introduction of FAdV-4 vaccines

Lai¹,

Min

Lai

et al. 2021

Avian Pathology

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“…Since 2011, Spain experienced an increase in the number of IBH outbreaks in meat-type commercial birds [16], with no exception to the worldwide rising trend of the last two decades [1,6]. Despite vaccination campaigns, IBH cases continue to be reported in Spain.…”

Section: Discussionmentioning

confidence: 99%

“…The higher incidence of FAdV over the last decades has been speculated to be linked to the efficacy of the elevated standards of biosecurity in preventing FAdV natural infection in breeder stocks [3,6,7]. Starting in 2010, biosecurity in breeder holdings increased substantially in Spain and other European countries due to Salmonella control programs [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Infections occurring before the waning of maternal antibodies (i.e., at around 18-24 days of age) are likely caused by vertical transmission, while infections at a later age normally involve horizontal transmission [1,3,6]. In order to infer the contribution of vertical versus horizontal transmission, IBH cases were classified based on age at time of diagnosis.…”

Section: Distribution Of Ibh Cases Based On Agementioning

confidence: 99%

“…In the last two decades, a growing number of IBH outbreaks due to FAdV-2, -8a, -8b, and -11 have been reported worldwide [1,[6][7][8][9][10][11][12][13][14][15]. In Spain, a sharp increase in the number of IBH outbreaks in broiler and broiler breeder pullet flocks has occurred since 2011.…”

Section: Introductionmentioning

confidence: 99%

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A 10-Year Retrospective Study of Inclusion Body Hepatitis in Meat-Type Chickens in Spain (2011–2021)

Bertran

Blanco²,

Antilles³

et al. 2021

Viruses

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A surge in fowl adenovirus (FAdV) causing inclusion body hepatitis (IBH) outbreaks has occurred in several countries in the last two decades. In Spain, a sharp increase in case numbers in broilers and broiler breeder pullets arose since 2011, which prompted the vaccination of breeders in some regions. Our retrospective study of IBH cases in Spain from 2011 to 2021 revealed that most cases were reported in broilers (92.21%) and were caused by serotypes FAdV-8b and -11, while cases in broiler breeder pullets were caused by serotypes FAdV-2, -11, and -8b. Vertical transmission was the main route of infection, although horizontal transmission likely happened in some broiler cases. Despite the inconsistent and heterogeneous use of vaccines among regions and over time, the number of cases mirrored the use of vaccines in the country. While IBH outbreaks were recorded year-long, significantly more cases occurred during the cooler and rainier months. The geographic distribution suggested a widespread incidence of IBH and revealed the importance of a highly integrated system. Our findings contribute to a better understanding of FAdV infection dynamics under field conditions and reiterate the importance of surveillance, serological monitoring of breeders, and vaccination of breeders against circulating serotypes to protect progenies.

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Development of an ELISA for the detection of fowl adenovirus serotype −4 utilizing fiber protein

Ather,

Zia,

Habib

et al. 2024

Biologicals

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Spotlight on avian pathology: fowl adenovirus (FAdV) in chickens and beyond – an unresolved host-pathogen interplay

Cited by 30 publications

References 29 publications

Epidemiology of fowl adenovirus (FAdV) infections in South Korean chickens during 2013–2019 following introduction of FAdV-4 vaccines

Epidemiology of fowl adenovirus (FAdV) infections in South Korean chickens during 2013–2019 following introduction of FAdV-4 vaccines

A 10-Year Retrospective Study of Inclusion Body Hepatitis in Meat-Type Chickens in Spain (2011–2021)

Development of an ELISA for the detection of fowl adenovirus serotype −4 utilizing fiber protein

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