Abstract:Risk Sohn, et al., pp. 1999Sohn, et al., pp. -2005 A particular genetic polymorphism can apparently decrease one's risk of colon cancer, yet increase risk of breast cancer. How does it work? Sohn et al. undertook to find out exactly what happens at the molecular level to induce this celltype-specific risk modification. They identified changes in intracellular folate cofactors resulting from the polymorphism that differ between colon and breast cancer cells, providing a possible explanation for the differences… Show more
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