Spot urine samples for evaluating solute excretion in the first week of life

Matos, Vera; Drukker, Alfred; Guignard, Jean‐Pierre

doi:10.1136/fn.80.3.f240

Cited by 24 publications

(20 citation statements)

References 23 publications

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“…With respect to the previous studies, however, we did not normalize the urinary AQP2 excretion for urinary creatinine. This because the urinary creatinine concentration during the 1st week varied widely among our patients, and, as also recommended in a previous work [24], the urinary creatinine concentration is an unreliable reference standard for the urinary excretion of solutes during the 1st week of life in newborns, particularly in preterm infants.…”

Section: Discussionmentioning

confidence: 98%

Aquaporin-2 Excretion and Renal Function during the 1st Week of Life in Preterm Newborn Infants

Iacobelli¹,

Addabbo

Bonsante

et al. 2006

Nephron Physiol

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In many preterm infants, a characteristic pattern of fluid and electrolyte homeostasis occurs during the 1st week of life, consisting of three phases: prediuretic, diuretic, and postdiuretic. In this study, we evaluated the possible role of aquaporin-2 (AQP2) in renal concentrating ability and correlated it with other markers of the renal function in healthy preterm infants. Daily urine and spot blood samples were collected from 9 healthy preterm (32 ± 1 weeks) infants at postnatal ages 1, 3, and 7 days. Urine and serum osmolality, creatinine, electrolytes, and AQP2 excretion were measured. All infants showed a significant (about 7%) weight loss on day 3 associated with a more than threefold increase in urine output without a significant change in fluid intake (diuretic phase). The creatinine clearance increased on day 3, indicating an increase in glomerular filtration rate. Interestingly, on day 3, the level of total excreted AQP2 (pmol/h) was significantly higher when compared to day 1 and day 7, and the same tendency was observed for urine osmolality. To conclude, the observed increase in urine osmolality and creatinine clearance during the diuretic phase, paralleled by an increase in total AQP2 excretion, suggests that AQP2 can contribute to the urinary concentrating ability early in postnatal life.

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Section: Discussionmentioning

confidence: 98%

Aquaporin-2 Excretion and Renal Function during the 1st Week of Life in Preterm Newborn Infants

Iacobelli¹,

Addabbo

Bonsante

et al. 2006

Nephron Physiol

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“…However, at days 1 and 2, creatinine concentrations and the levels of 8-oxoGua and 8-oxodG were very similar to concentrations characteristic for adults. Therefore, at these days the values possibly represent those of the mother (for a specific discussion of this issue see Matos et al [20] …”

Section: Human Studiesmentioning

confidence: 99%

Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns

Dziaman¹,

Gackowski²,

Różalski³

et al. 2007

Free Radical Research

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The aim of the present study was to evaluate the oxidative status in healthy full-term children and piglets. Urinary excretion of 8-oxoGua (8-oxoguanine) and 8-oxodG (8-oxo-2'-deoxyguanosine) were determined using HPLC/GS/MS methodology and concentrations of vitamins A, C and E with HPLC technique. The levels of 8-oxoGua in urine samples were about 7-8 times higher in newborn children and piglets when compared with the level of adult subjects, while in the case of 8-oxodG the difference was about 2.5 times. The levels of vitamin C and E in umbilical cord blood of newborn children significantly depend on the concentration of these compounds in their mother's blood. However, the values of vitamin C in human's cord blood were about 2-times higher than in respective mother blood, while the level of vitamin E showed an opposite trend. The results suggest that: (i) healthy, full-term newborns are under potential oxidative stress; (ii) urinary excretion of 8-oxoGua and 8-oxodG may be a good marker of oxidative stress in newborns; and (iii) antioxidant vitamins, especially vitamin C, play an important role in protecting newborns against oxidative stress.

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“…We indexed the urinary concentration of nitrite to the urinary concentration of creatinine to correct any confounding effects of renal dysfunction. There is no other suggested way to normalize the nitrite excretion levels, even though we know that the urinary creatinine concentrations can show great variability in the first week of life [26,28].…”

Section: Methodsmentioning

confidence: 99%

Urinary Nitrite Excretion after Prophylactic Intravenous Immunoglobulin in Premature Infants

Özkan¹,

Uzuner²,

Ören³

et al. 2000

Neonatology

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Aims: To investigate the correlation between the prophylactic administration of intravenous immunoglobulin (IVIG) to preterm infants and urinary nitrite levels, which can be utilized as an index of endogenous nitric oxide (NO) formation, and to determine if NO formation plays a role in both therapeutic and adverse effects of IVIG. Methods: 28 healthy preterm infants were included in this prospective study. They had a mean gestational age of 29.4 ± 2.2 weeks and weight of 1,387 ± 371 g. Prophylactic IVIG infusion at a dose of 0.5 g/kg/day was administered when they were 3–10 days old. Urine samples of the neonates were obtained for analysis on days 1, 2 and 3 after IVIG administration as well as 1 day before. Urinary nitrite levels obtained in the subjects were normalized for urinary creatinine concentrations. Results: The mean urinary nitrite levels were: 2.77 ± 1.66 μmol/mmol creatinine before IVIG administration; 4.33 ± 3.88 μmol/mmol creatinine on the 1st day of IVIG; 3.77 ± 2.73 μmol/mmol creatinine on the 2nd day, and 3.64 ± 3.28 μmol/mmol creatinine on the 3rd day. There was a significant increase in urinary nitrite levels between before and after IVIG administration. There was no statistical difference in urinary nitrate levels between days 1, 2 and 3 after IVIG administration. Conclusion: We demonstrated that urinary nitrite excretion is significantly elevated in preterm infants after prophylactic IVIG administration and this result suggests that endogenous NO formation may play an important role in both the therapeutic and adverse effects of IVIG.

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Spot urine samples for evaluating solute excretion in the first week of life

Cited by 24 publications

References 23 publications

Aquaporin-2 Excretion and Renal Function during the 1st Week of Life in Preterm Newborn Infants

Aquaporin-2 Excretion and Renal Function during the 1st Week of Life in Preterm Newborn Infants

Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns

Urinary Nitrite Excretion after Prophylactic Intravenous Immunoglobulin in Premature Infants

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