Spot Test for Vanillylmandelic Acid and Other Guaiacols in Urine of Patients with Neuroblastoma

Rogers, Lon E.; Lyon, G. Marshall; Porter, F. Stanley

doi:10.1093/ajcp/58.5.383

Cited by 10 publications

(2 citation statements)

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“… 58 Guaiacol is reported to be found in the urine of patients with neuroblastoma and pheochromocytoma. 62 Guaiacol was found to be overexpressed by 1.76 folds in IDC with respect to HC group and had a VIP score of 1.38 in our study. The up-regulation pattern of guaiacol in IDC is suggestive of its potential role in cell proliferation since it is one of the primary characteristics of the malignant cells.…”

Section: Discussionsupporting

confidence: 51%

A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

Taunk

Taware

et al. 2018

RSC Adv.

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Section: Discussionsupporting

confidence: 51%

A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

Taunk

Taware

et al. 2018

RSC Adv.

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“…Guaiacol, a methoxyphenol compound, is produced through the pyrolysis of lignin and has also been proposed as a marker of WS exposure. However, unlike levoglucosan, guaiacol may be carcinogenic as it can enhance cell proliferatation and has been found in the urine of patients with neuroblastoma 48 . Interestingly, guaiacol has been identified as a potent antioxidant 49 with good reactive species scavenging potential.…”

Section: Discussionmentioning

confidence: 99%

Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway

Zeglinski

Turner

Zhou

et al. 2019

Sci Rep

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Wildfire smoke induces acute pulmonary distress and is of particular concern to risk groups such as the sick and elderly. Wood smoke (WS) contains many of the same toxic compounds as those found in cigarette smoke (CS) including polycyclic aromatic hydrocarbons, carbon monoxide, and free radicals. CS is a well-established risk factor for respiratory diseases such as asthma and COPD. Limited studies investigating the biological effects of WS on the airway epithelium have been performed. Using a cell culture-based model, we assessed the effects of a WS-infused solution on alveolar epithelial barrier function, cell migration, and survival. The average geometric mean of particles in the WS was 178 nm. GC/MS analysis of the WS solution identified phenolic and cellulosic compounds. WS exposure resulted in a significant reduction in barrier function, which peaked after 24 hours of continuous exposure. The junctional protein E-cadherin showed a prominent reduction in response to increasing concentrations of WS. Furthermore, WS significantly repressed cell migration following injury to the cell monolayer. There was no difference in cell viability following WS exposure. Mechanistically, WS exposure induced activation of the p44/42, but not p38, MAPK signaling pathway, and inhibition of p44/42 phosphorylation prevented the disruption of barrier function and loss of E-cadherin staining. Thus, WS may contribute to the breakdown of alveolar structure and function through a p44/42 MAPK-dependent pathway and may lead to the development and/or exacerbation of respiratory pathologies with chronic exposure.

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The diagnostic dilemma of the “small round cell neoplasm”: Catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma

Reynolds

Smith

Frenkel

1981

Cancer

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Small round cell neoplasms, which include neuroblastoma, Ewing's sarcoma, embryonal rhabdomyosarcoma, oat cell carcinoma, and lymphoma, are often confused with one another histologically. The advent of successful but distinct therapeutic approaches for different neoplasms has increased the need for precise diagnosis. The use of techniques ancillary to routine histologic or ultrastructural analysis allows better definition of the specific tumor type. Four cases of small cell tumor are described in which the initial working diagnosis was incorrect. The application of two diagnostic procedures for neuroblastoma was of great value to clarifying the proper diagnosis. These tests were a rapid fluorescence assay for intracellular catecholamines and a tissue culture assay for neurite outgrowth. Both of these methods are highly sensitive for neuroblastoma and distinguish neuroblastoma from other small round cell neoplasms. Their use confirmed this unsuspected diagnosis in three cases and excluded neuroblastoma in the fourth case.

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Spot Test for Vanillylmandelic Acid and Other Guaiacols in Urine of Patients with Neuroblastoma

Cited by 10 publications

References 0 publications

A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway

The diagnostic dilemma of the “small round cell neoplasm”: Catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma

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