Abstract:Background: The diagnosis of Tuberculosis (TB) using smear microscopy has been based on testing 2 specimens: one spot and one early morning sputum. Recently, the World Health Organization (WHO) recommended to replace, whenever possible, microscopy with GeneXpert® MTB/RIF performed on a single specimen. However, as the bacterial load is higher in early morning specimens than in spot specimens, one could expect lower sensitivity of GeneXpert® MTB/RIF performed only on spot specimens. In this study, we compared r… Show more
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