Spot Scanning Using Radioactive<sup>11</sup>C Beams for Heavy-Ion Radiotherapy

Urakabe, E.; Kanai, Tatsuaki; Kanazawa, M.; Kitagawa, A.; Noda, K.; Tomitani, Takehiro; Suda, M.; Iseki, Y.; Hanawa, K.; Sato, K.; Shimbo, Munefumi; Mizuno, Hideyuki; Hirata, Yoshito; Futami, Yasuyuki; Iwashita, Yoshihisa; Noda, Akira

doi:10.1143/jjap.40.2540

Cited by 70 publications

(40 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2001, Urakabe et al . demonstrated that a positron-emitting 11 C scanned spot beam could be directly used as the therapeutic agent 29 . However, the estimate of RBE 10 used to obtain a flat biological dose was based on an extrapolation of previously-reported results for 12 C in water, which was assumed to extend to human tissue 30 .…”

Section: Related Workmentioning

confidence: 99%

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Chacon

Safavi-Naeini

Bolst

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

This work presents a simulation study evaluating relative biological effectiveness at 10% survival fraction (RBE10) of several different positron-emitting radionuclides in heavy ion treatment systems, and comparing these to the RBE10s of their non-radioactive counterparts. RBE10 is evaluated as a function of depth for three positron-emitting radioactive ion beams ( 10 C, 11 C and 15 O) and two stable ion beams ( 12 C and 16 O) using the modified microdosimetric kinetic model (MKM) in a heterogeneous skull phantom subject to a rectangular 50 mm × 50 mm × 60 mm spread out Bragg peak. We demonstrate that the RBE10 of the positron-emitting radioactive beams is almost identical to the corresponding stable isotopes. The potential improvement in PET quality assurance image quality which is obtained when using radioactive beams is evaluated by comparing the signal to background ratios of positron annihilations at different intra- and post-irradiation time points. Finally, the incidental dose to the patient resulting from the use of radioactive beams is also quantified and shown to be negligible.

show abstract

Section: Related Workmentioning

confidence: 99%

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Chacon

Safavi-Naeini

Bolst

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…The validity of the beam model and the optimization calculation had already been verified experimentally 15,16 by using the HIMAC spot scanning test course. 27 In the present simulation, we employed the measured dose response of the pencil beam with an energy of 350 MeV/ u, which corresponded to a 220 mm range in water. The beam size at the entrance and the width of the Gaussian-shaped mini peak was 3.5 and 4 mm at 1, respectively.…”

Section: Simulation Of Moving Target Irradiation With Rescanningmentioning

confidence: 99%

Design study of a raster scanning system for moving target irradiation in heavy‐ion radiotherapy

Furukawa¹,

Inaniwa²,

Sato³

et al. 2007

Medical Physics

Self Cite

125

View full text Add to dashboard Cite

A project to construct a new treatment facility as an extension of the existing heavy-ion medical accelerator in chiba (HIMAC) facility has been initiated for further development of carbon-ion therapy. The greatest challenge of this project is to realize treatment of a moving target by scanning irradiation. For this purpose, we decided to combine the rescanning technique and the gated irradiation method. To determine how to avoid hot and/or cold spots by the relatively large number of rescannings within an acceptable irradiation time, we have studied the scanning strategy, scanning magnets and their control, and beam intensity dynamic control. We have designed a raster scanning system and carried out a simulation of irradiating moving targets. The result shows the possibility of practical realization of moving target irradiation with pencil beam scanning. We describe the present status of our design study of the raster scanning system for the HIMAC new treatment facility.

show abstract

“…Although this method achieves production rates of almost 1%, which are deemed sufficient for testing purposes, the radioactive ion beams produced are considerably broad and feature larger momentum spreads than the projectile beam ( 36 , 38 ). Moreover, the production method is also characterized by the presence of impurities in the secondary beam, originating from the projectile fragments.…”

Section: Motivation For Carbon-11 Beams: Overview and Modelingmentioning

confidence: 99%

Technical Design Report for a Carbon-11 Treatment Facility

Penescu¹,

Stora

Stegemann

et al. 2022

Front. Med.

View full text Add to dashboard Cite

Particle therapy relies on the advantageous dose deposition which permits to highly conform the dose to the target and better spare the surrounding healthy tissues and organs at risk with respect to conventional radiotherapy. In the case of treatments with heavier ions (like carbon ions already clinically used), another advantage is the enhanced radiobiological effectiveness due to high linear energy transfer radiation. These particle therapy advantages are unfortunately not thoroughly exploited due to particle range uncertainties. The possibility to monitor the compliance between the ongoing and prescribed dose distribution is a crucial step toward new optimizations in treatment planning and adaptive therapy. The Positron Emission Tomography (PET) is an established quantitative 3D imaging technique for particle treatment verification and, among the isotopes used for PET imaging, the 11C has gained more attention from the scientific and clinical communities for its application as new radioactive projectile for particle therapy. This is an interesting option clinically because of an enhanced imaging potential, without dosimetry drawbacks; technically, because the stable isotope 12C is successfully already in use in clinics. The MEDICIS-Promed network led an initiative to study the possible technical solutions for the implementation of 11C radioisotopes in an accelerator-based particle therapy center. We present here the result of this study, consisting in a Technical Design Report for a 11C Treatment Facility. The clinical usefulness is reviewed based on existing experimental data, complemented by Monte Carlo simulations using the FLUKA code. The technical analysis starts from reviewing the layout and results of the facilities which produced 11C beams in the past, for testing purposes. It then focuses on the elaboration of the feasible upgrades of an existing 12C particle therapy center, to accommodate the production of 11C beams for therapy. The analysis covers the options to produce the 11C atoms in sufficient amounts (as required for therapy), to ionize them as required by the existing accelerator layouts, to accelerate and transport them to the irradiation rooms. The results of the analysis and the identified challenges define the possible implementation scenario and timeline.

show abstract

Spot Scanning Using Radioactive¹¹C Beams for Heavy-Ion Radiotherapy

Cited by 70 publications

References 12 publications

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Design study of a raster scanning system for moving target irradiation in heavy‐ion radiotherapy

Technical Design Report for a Carbon-11 Treatment Facility

Contact Info

Product

Resources

About

Spot Scanning Using Radioactive11C Beams for Heavy-Ion Radiotherapy

Cited by 70 publications

References 12 publications

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy

Design study of a raster scanning system for moving target irradiation in heavy‐ion radiotherapy

Technical Design Report for a Carbon-11 Treatment Facility

Contact Info

Product

Resources

About

Spot Scanning Using Radioactive¹¹C Beams for Heavy-Ion Radiotherapy