Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions

Mein, Stewart; Tessonnier, Thomas; Kopp, Benedikt; Harrabi, Semi; Abdollahi, Amir; Debus, Jürgen; Haberer, Thomas; Mairani, A.

doi:10.1016/j.adro.2021.100661

Cited by 21 publications

(36 citation statements)

References 60 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible to achieve higher quality XRT plans with VMAT and a significantly faster BDT than with multiple static beams ( 189 ). This concept applied to PBT is termed proton arc therapy (PAT) ( 190 ), combined with PBS, spot-scanning proton arc (SPArc) ( 191 ) and with other ions (helium and carbon), spot-scanning hadron arc (SHarc) therapy ( 192 ). This delivery technique is highly complex and a fundamental challenge again lies with the capacity of the BDS: it must deliver reliably and continuously along rotational arcs, with the ability to switch quickly between energy layers ( 193 ).…”

Section: Emerging Applicationsmentioning

confidence: 99%

“…A planning study by Mein et al. ( 192 ) evaluates SHarc with different field configurations using proton, helium and carbon ion beams ( Figure 13 ). The results demonstrate several possible clinical benefits such as a lower dose bath, minimization of high-LET components on critical structures and better tumor control with normal tissue toxicity reduction.…”

Section: Emerging Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

The physical and clinical benefits of charged particle therapy (CPT) are well recognized. However, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. Yet, the issue of cost remains a primary hurdle as utility of CPT is largely driven by the affordability, complexity and performance of current technology. Modern delivery techniques are necessary but limited by extended treatment times. Several of these aspects can be addressed by developments in the beam delivery system (BDS) which determines the overall shaping and timing capabilities enabling high quality treatments. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimize the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of advanced modalities and faster delivery for a greater range of treatment indications which could also further reduce costs. Further work to realize methodologies such as volumetric rescanning, FLASH, arc, multi-ion and online image guided therapies are discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with improvements in beam delivery and how this could lead to faster and higher quality treatments for the future of CPT.

show abstract

Section: Emerging Applicationsmentioning

confidence: 99%

Section: Emerging Applicationsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

View full text Add to dashboard Cite

show abstract

“…It is possible to achieve higher quality plans with VMAT and a significantly faster BDT than with multiple static beams [158]. This concept applied to PBT is termed proton arc therapy (PAT) [159], combined with PBS, spot-scanning proton arc (SPArc) [160] and with other ions (helium and carbon), spot-scanning hadron arc (SHarc) therapy [161]. This delivery technique is highly complex and a fundamental challenge again lies with the capacity of the BDS: it must deliver reliably and continuously along rotational arcs, with the ability to switch quickly between energy layers [162].…”

Section: Arc Therapymentioning

confidence: 99%

“…As with multi-ion radiotherapy (MIRT), combining different particle types for an effective mix of low-and high-LET regions could generate a higher dosimetric quality plan by utilising favourable characteristics. A planning study by Mein et al [161] evaluates SHarc with different field configurations using proton, helium and carbon ion beams (Figure 13). The results demonstrate several possible clinical benefits such as a lower dose bath, minimisation of high-LET components on critical structures and better tumour control with normal tissue toxicity reduction.…”

Section: Arc Therapymentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Yap,

De Franco,

Sheehy

2021

Preprint

View full text Add to dashboard Cite

The physical and clinical benefits of charged particle therapy (CPT) are well recognised and recent developments have led to the rapid emergence of facilities, resulting in wider adoption worldwide. Nonetheless, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. The issue of cost however still remains a primary hurdle as the utility of CPT is largely driven by the affordability, complexity and performance of current technology. Several of these aspects can be addressed by developments to the beam delivery system (BDS) which determine the overall shaping and timing capabilities to provide high quality treatments. Modern delivery techniques are necessary but are limited by extended treatment times. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimise the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of delivering advanced methodologies such as volumetric rescanning, FLASH and arc therapy and can further reduce costs given a faster delivery for a greater range of treatment indications. Further work to realise multi-ion, image guided and adaptive therapies is also discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with an improved BDS and how this could lead to faster and higher quality treatments for the future of CPT.

show abstract

“…They are the simplest and most abundant cations formed in the cosmos [ 76 , 77 ], and the velocities applied here correspond to slow-speed solar wind [ 76 ]. Moreover, medical hadrontherapy procedures usually utilize protons to irradiate deep-seated tumors [ 78 , 79 ], but other ionic beams are also expected to be a propitious source of radiation [ 79 , 80 , 81 , 82 , 83 ]. Hence, H + and H 2 + are model projectiles to explore the ion–molecule interactions in cosmic and biological environments, respectively.…”

Section: Introductionmentioning

confidence: 99%

Neutral Dissociation of Pyridine Evoked by Irradiation of Ionized Atomic and Molecular Hydrogen Beams

Wąsowicz

2021

IJMS

View full text Add to dashboard Cite

The interactions of ions with molecules and the determination of their dissociation patterns are challenging endeavors of fundamental importance for theoretical and experimental science. In particular, the investigations on bond-breaking and new bond-forming processes triggered by the ionic impact may shed light on the stellar wind interaction with interstellar media, ionic beam irradiations of the living cells, ion-track nanotechnology, radiation hardness analysis of materials, and focused ion beam etching, deposition, and lithography. Due to its vital role in the natural environment, the pyridine molecule has become the subject of both basic and applied research in recent years. Therefore, dissociation of the gas phase pyridine (C5H5N) into neutral excited atomic and molecular fragments following protons (H+) and dihydrogen cations (H2+) impact has been investigated experimentally in the 5–1000 eV energy range. The collision-induced emission spectroscopy has been exploited to detect luminescence in the wavelength range from 190 to 520 nm at the different kinetic energies of both cations. High-resolution optical fragmentation spectra reveal emission bands due to the CH(A2Δ → X2Πr; B2Σ+ → X2Πr; C2Σ+ → X2Πr) and CN(B2Σ+ → X2Σ+) transitions as well as atomic H and C lines. Their spectral line shapes and qualitative band intensities are examined in detail. The analysis shows that the H2+ irradiation enhances pyridine ring fragmentation and creates various fragments more pronounced than H+ cations. The plausible collisional processes and fragmentation pathways leading to the identified products are discussed and compared with the latest results obtained in cation-induced fragmentation of pyridine.

show abstract

Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions

Cited by 21 publications

References 60 publications

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Neutral Dissociation of Pyridine Evoked by Irradiation of Ionized Atomic and Molecular Hydrogen Beams

Contact Info

Product

Resources

About