Sporulation in Physarum polycephalum *1A model system for studies on differentiation

Sauer, Helmut W.; Babcock, Karlee L.; Rusch, H. P.

doi:10.1016/0014-4827(69)90156-6

Cited by 70 publications

(49 citation statements)

References 17 publications

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“…Temperature was kept between 24 0 Cand29 0 C. Cultures fruited during the 12 hours following illumination and were completely melanized by 14 hours, as observed by Sauer et al (1969).…”

Section: Methodsmentioning

confidence: 99%

“…Sauer et al (1969) chose the sporulating plasmodium for development of a model system for the study of differentiation because "it contains many of the characteristics of differentiation--competence, commitment...(and)... morphogenesis."…”

Section: Introductionmentioning

confidence: 99%

“…Our progress to date has consisted of testing several of the published systems--microplasmodial growth (Becker et al, 1963), sporulation (Sauer et al, 1969), and amoebal flagellation (Mir and Wright, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…Daniel and Rusch (1962) found that despite the complexity of the morphological changes occurring during the sporulation process (Guttes et al, 1961), the entire chain of events could be induced by simply starving a culture on a niacin-salts solution for several days and then exposing it to light. Sauer et al (1969) found that once a plasmodium had been illuminated, the events in morphogenesis occurred at fixed times. Some of the most obvious changes were the appearance of sporangial buds at 7 hr, a synchronous nuclear division at 13 hr, spore cleavage at 13.5 hr and melanization at 14 hr after the end of illumination.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Use of Physarum for Testing of Toxicity/Mutagenicity

Mohberg¹

1984

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“…Temperature was kept between 24 0 Cand29 0 C. Cultures fruited during the 12 hours following illumination and were completely melanized by 14 hours, as observed by Sauer et al (1969).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Use of Physarum for Testing of Toxicity/Mutagenicity

Mohberg¹

1984

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“…A plasmodium moves away from light when it can or switches to another phase of its life cycle or undergoes fragmentation when it cannot escape from light. If a plasmodium, especially a starving one [54], is subjected to a high intensity of light, the plasmodium turns into a sporulation phase [55]. The illumination increase causes changes in the plasmodium's oscillatory activity; the degree of change is proportional to the distance from the light source [56,57].…”

Section: (C) Colour Sensormentioning

confidence: 99%

Slime mould processors, logic gates and sensors

Adamatzky

2015

Phil. Trans. R. Soc. A.

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A heterotic, or hybrid, computation implies that two or more substrates of different physical nature are merged into a single device with indistinguishable parts. These hybrid devices then undertake coherent acts on programmable and sensible processing of information. We study the potential of heterotic computers using slime mould acting under the guidance of chemical, mechanical and optical stimuli. Plasmodium of acellular slime mould Physarum polycephalum is a gigantic single cell visible to the unaided eye. The cell shows a rich spectrum of behavioural morphological patterns in response to changing environmental conditions. Given data represented by chemical or physical stimuli, we can employ and modify the behaviour of the slime mould to make it solve a range of computing and sensing tasks. We overview results of laboratory experimental studies on prototyping of the slime mould morphological processors for approximation of Voronoi diagrams, planar shapes and solving mazes, and discuss logic gates implemented via collision of active growing zones and tactile responses of P. polycephalum. We also overview a range of electronic components-memristor, chemical, tactile and colour sensors-made of the slime mould.

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Detecting functional interactions in a gene and signaling network by time‐resolved somatic complementation analysis

Marwan

2003

BioEssays

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Somatic complementation by fusion of two mutant cells and mixing of their cytoplasms occurs when the genetic defect of one fusion partner is cured by the functional gene product provided by the other. We have found that complementation of mutational defects in the network mediating stimulus-induced commitment and sporulation of Physarum polycephalum may reflect time-dependent changes in the signaling state of its molecular building blocks. Network perturbation by fusion of mutant plasmodial cells in different states of activation, and the time-resolved analysis of somatic complementation effects can be used to systematically probe network structure and dynamics. Time-resolved somatic complementation quantitatively detects regulatory interactions between the functional modules of a network, independent of their biochemical composition or subcellular localization, and without being limited to direct physical interactions.

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Sporulation in Physarum polycephalum *1A model system for studies on differentiation

Cited by 70 publications

References 17 publications

The Use of Physarum for Testing of Toxicity/Mutagenicity

The Use of Physarum for Testing of Toxicity/Mutagenicity

Slime mould processors, logic gates and sensors

Detecting functional interactions in a gene and signaling network by time‐resolved somatic complementation analysis

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