Sports-related sudden cardiac death in Spain. A multicenter, population-based, forensic study of 288 cases

Morentín, Benito; Suárez-Mier, M. Paz; Monzó, Ana; Ballesteros, Javier; Molina, Pilar; Lucena, J.

doi:10.1016/j.rec.2020.05.044

Cited by 10 publications

(11 citation statements)

References 24 publications

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“…Supplementary Table 1 summarizes the main papers reporting the cause of death in sports-related SCD series. As expected, the percentage of SCD attributable to coronary artery disease (CAD) increases paralleling the age of the recruited victims, with a maximal prevalence (63%) in the Spanish study by Morentin et al (n = 288) which also reported male predominance and the highest mean age (44 ± 14 years old) of the reviewed series (28). For unknown reasons, even though Spain is considered a country with low prevalence of CAD, its 63% CAD prevalence ( 28) is double as much as that observed in the Danish series reported by Risgaard et al, with a similar age (41 ± 10 years old) and also with male predominance but with a remarkably smaller sample size (N = 44).…”

Section: Observational Studies: Acm In Sports-triggered Sudden Cardiac Deathsupporting

confidence: 56%

“…Published papers have tried to shed some light on the causes of sports-related SCD from a wide range of settings and based on a variable percentage of forensic studies. They have underlined that ACM represents a not negligible cause of death in this scenario, accounting for roughly 0-28% of the autopsied cases (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The fact that in non-autopsy-based studies ACM is sometimes not even mentioned highlights the difficulties in getting a firm diagnosis when cardiac pathology is missing, as it often happens both in SCD and in sudden cardiac arrest reports (29,30).…”

Section: Observational Studies: Acm In Sports-triggered Sudden Cardiac Deathmentioning

confidence: 99%

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Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach

Martínez-Solé

Sabater-Molina

Braza-Boïls

et al. 2021

Front. Cardiovasc. Med.

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Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by fibrofatty myocardial replacement, either at the right ventricle, at the left ventricle, or with biventricular involvement. Ventricular arrhythmias and heart failure represent its main clinical features. Exercise benefits on mental and physical health are worldwide recognized. However, patients with ACM appear to be an exception. A thorough review of the literature was performed in PubMed searching for original papers with the terms “ARVC AND sports/exercise” and “sudden cardiac death AND sports/exercise.” Additional papers were then identified through other sources and incorporated to the list. All of them had to be based on animal models or clinical series. Information was structured in a regular format, although some data were not available in some papers. A total of 34 papers were selected and processed regarding sports-related sudden cardiac death, pre-clinical models of ACM and sport, and clinical series of ACM patients engaged in sports activities. Eligible papers were identified to obtain pooled data in order to build representative figures showing the global incidence of the most important causes of sudden cardiac death in sports and the global estimates of life-threatening arrhythmic events in ACM patients engaged in sports. Tables and figures illustrate their major characteristics. The scarce points of controversy were discussed in the text. Fundamental concepts were summarized in three main issues: sports may accelerate ACM phenotype with either structural and/or arrhythmic features, restriction may soften the progression, and these rules also apply to phenotype-negative mutation carriers. Additionally, remaining gaps in the current knowledge were also highlighted, namely, the applicability of those fundamental concepts to non-classical ACM phenotypes since left dominant ACM or non-plakophillin-2 genotypes were absent or very poorly represented in the available studies. Hopefully, future research endeavors will provide solid evidence about the safest exercise dose for each patient from a personalized medicine perspective, taking into account a big batch of genetic, epigenetic, and epidemiological variables, for instance, in order to assist clinicians to provide a final tailored recommendation.

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Section: Observational Studies: Acm In Sports-triggered Sudden Cardiac Deathsupporting

confidence: 56%

Section: Observational Studies: Acm In Sports-triggered Sudden Cardiac Deathmentioning

confidence: 99%

Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach

Martínez-Solé

Sabater-Molina

Braza-Boïls

et al. 2021

Front. Cardiovasc. Med.

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“…Strenuous physical activity seems to increase the risk of SCD temporarily and the least fit population is at the highest risk [ 17 ]. However, in our study, the old experienced less frequently SCD during or after physical activity, which is in line with the other studies [ 18 , 19 ]. The trend is understandable since physical activity decreases with age [ 20 , 21 ], especially moderate and strenuous exercise [ 21 ].…”

Section: Discussionsupporting

confidence: 93%

Causes and characteristics of unexpected sudden cardiac death in octogenarians/nonagenarians

et al. 2023

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Introduction The risk for sudden cardiac death (SCD) increases with ageing. Methods We evaluated causes and characteristics of unexpected SCD in SCD victims aged ≥ 80 years in a consecutive series of 5,869 SCD victims in Northern Finland. All the victims underwent medico-legal autopsy as medico-legal autopsy is mandatory in cases of unexpected sudden death in Finland. All the non-cardiac deaths such as pulmonary embolism and cerebral hemorrhage were excluded from the study, as were unnatural deaths such as intoxications. Results Among SCD victims ≥ 80 years, 91.0% of SCDs were due to ischemic heart disease (IHD) determined in autopsy and 9.0% due to non-ischemic heart disease (NIHD), whereas among those < 80 years, only 72.6% of SCDs were due to IHD and 27.4% due to NIHD (P < .001). Severe fibrosis in myocardium was more common whereas heart weight and liver weight, body mass index and abdominal fat thickness, were lower among SCD victims aged ≥ 80 years than among victims aged < 80 years. In those with IHD as etiology of SCD, at least 75% stenosis in one or more major coronary vessels was more common in SCD victims aged ≥ 80 years than among victims aged < 80 years (P = .001). SCD victims 80 years or older were less likely to die during physical activity than those under 80 years old (5.6% vs. 15.9%, P < .001). Dying in sauna was more common among those ≥ 80 years than among those < 80 years (5.5% vs. 2.6%, P < .001). Conclusion In victims of unexpected SCD aged ≥ 80 years, the autopsy-based etiology of SCD was more commonly IHD than in those aged < 80 years. In SCD victims aged ≥ 80 years, severe fibrosis in myocardium, representing arrhythmic substrate, was more common than in the younger ones.

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“…En España 11,12 , fútbol, ciclismo y atletismo (carreras) son los deportes más frecuentemente asociados a MSC, atribuida a canalopatía en 6% de los casos 12 .…”

Section: Discussionunclassified

Muerte súbita por fibrilación ventricular en deportista. Una presentación inusual del Síndrome de Brugada. Caso Clínico

Lira

et al. 2021

Rev. méd. Chile

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Sports-related sudden cardiac death in Spain. A multicenter, population-based, forensic study of 288 cases

Cited by 10 publications

References 24 publications

Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach

Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach

Causes and characteristics of unexpected sudden cardiac death in octogenarians/nonagenarians

Muerte súbita por fibrilación ventricular en deportista. Una presentación inusual del Síndrome de Brugada. Caso Clínico

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