Sporotrichosis

Scott, E. N.; Muchmore, H. G.

doi:10.1007/978-1-4899-2400-1_6

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Cutaneous sporotrichosis is the most common form, including lymphocutaneous sporotrichosis (LS) and fixed cutaneous sporotrichosis (FCS). LS and FCS account for the majority of clinical cases, and disseminated sporotrichosis (DS) is infrequent [1–3]. It is well‐known that the clinical form of sporotrichosis depends on the host's immune condition [4–6].…”

Section: Introductionmentioning

confidence: 99%

Relationships among genotypes, virulence and clinical forms of Sporothrix schenckii infection

Kong

Xiao

Lin

et al. 2006

Clinical Microbiology and Infection

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This study explored the relationships among genotypes, virulence and clinical forms of Sporothrix schenckii. Genomic DNA from isolates of S. schenckii, collected from different clinical forms of sporotrichosis, was amplified by randomly amplified polymorphic DNA (RAPD). Suspensions of different isolates of S. schenckii were inoculated into healthy BALB/c mice to compare their virulence, and the numbers and distribution of spores were determined by histological analysis. RAPD analysis indicated that the isolates from different clinical forms of sporotrichosis belonged to different genotypes. The mice inoculated with isolates from disseminated sporotrichosis showed an earlier onset of illness and more severe lesions than those inoculated with isolates from lymphocutaneous sporotrichosis, which, in turn, showed an earlier onset of illness and more severe lesions than those inoculated with isolates from fixed cutaneous sporotrichosis. Healthy BALB/c mice injected with isolates from disseminated sporotrichosis died within 10 days, whereas isolates from lymphocutaneous sporotrichosis and fixed cutaneous sporotrichosis failed to cause death. Histologically, mice inoculated with isolates from disseminated sporotrichosis had more spores than those inoculated with isolates from lymphocutaneous sporotrichosis and fixed cutaneous sporotrichosis. Thus, different genotypes may be associated closely with the virulence of different clinical forms of S. schenckii infection.

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Section: Introductionmentioning

confidence: 99%

Relationships among genotypes, virulence and clinical forms of Sporothrix schenckii infection

Kong

Xiao

Lin

et al. 2006

Clinical Microbiology and Infection

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Entomophthoromycosis of the nose and paranasal sinus

et al. 2000

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Characteristic infectivity ofSporothrix schenckiito mice depending on routes of infection and inherent fungal pathogenicity

Tachibana¹,

Matsuyama²,

Mitsuyama³

1998

Med Mycol

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Isolates of Sporothrix schenckii were examined for their infectivity in BALB/c mice. The mice were injected with yeast forms of S. schenckii isolates differing in clinical source (human cutaneous lesions and pulmonary lesions), and fungal growth was determined at intervals in the footpad and visceral organs. After subcutaneous injection of approximately 10 colony forming units (cfu) of S. schenckii into the footpad, locally restricted fungal infection developed gradually. At the peak of the infection (3-4 weeks post-inoculation), viable fungal counts reached 102-106 cfu/footpad. Dissemination to other tissues and visceral organs was not observed. After intravenous or intraperitoneal injection of 106 cfu of yeast forms, three of four isolates from cutaneous sporotrichosis were unable to establish infection and were eliminated from blood and visceral organs. The development of systemic infection was observed only with S. schenckii isolates obtained from the human lung lesion. Thus, inherent properties of each clinical isolate and routes of infection were shown to be critical for the establishment of systemic infection in spite of the remarkably strong infectivity of S. schenckii to the cutaneous tissue.

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Sporotrichosis

Cited by 3 publications

References 49 publications

Relationships among genotypes, virulence and clinical forms of Sporothrix schenckii infection

Relationships among genotypes, virulence and clinical forms of Sporothrix schenckii infection

Entomophthoromycosis of the nose and paranasal sinus

Characteristic infectivity ofSporothrix schenckiito mice depending on routes of infection and inherent fungal pathogenicity

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