Sporotrichosis caused by Sporothrix brasiliensis in Argentina: Case report, molecular identification and in vitro susceptibility pattern to antifungal drugs

Etchecopaz, A.N.; Lanza, Natalia; Toscanini, María A.; Devoto, Tomás Brito; Pola, S. J.; Daneri, Gabriela Löpez; Iovannitti, C.; Cuestas, María Luján

doi:10.1016/j.mycmed.2019.100908

Cited by 61 publications

(62 citation statements)

References 15 publications

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“…Outside Brazil, to date, only Argentina has reported the occurrence of S. brasiliensis infection in humans and cats [4,5] which is alarming because this suggests the transboundary expansion of sporotrichosis caused by S. brasiliensis to other Latin America countries [2]. Importantly, health authorities of Brazilian neighboring countries which have a dense transit of people and animals in a daily basis, such as Argentina, Paraguay, Bolivia, and Uruguay, should be aware to identify cases rapidly as well as, to implement policies for prevention and control of sporotrichosis.…”

Section: Spatial Distribution Of Feline Sporotrichosis Caused By S Bmentioning

confidence: 99%

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Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

et al. 2020

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We herein present a Brazilian guideline for the management of feline sporotrichosis, a mycosis caused by Sporothrix brasiliensis. This guideline is an effort of a national technical group organized by the Working Group on Sporothrix and Sporotrichosis of the International Society for Human and Animal Mycology (ISHAM). This publication intends to provide information on clinicalepidemiological aspects of this zoonosis, as well as a literature revision. Moreover, it gives some practical information on diagnosis and treatment of feline sporotrichosis. It also contains information that can be helpful for the prevention and control of S. brasiliensis transmission.

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Section: Spatial Distribution Of Feline Sporotrichosis Caused By S Bmentioning

confidence: 99%

“…The geographic expansion of zoonotic sporotrichosis to the northeast region of the country occurred in the last 5 years [2]. Recently, feline and zoonotic cases were reported in other South American countries [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

et al. 2020

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“…Sporothrix brasiliensis has been described as an emerging species that is highly pathogenic among humans and cats with a predominant geographic distribution in Brazil, although it was recently described in Argentina as well [19,22,28,[32][33][34][35][36][37][38][39]. Few studies have characterized canine isolates of the genus Sporothrix.…”

Section: Introductionmentioning

confidence: 99%

Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles of Sporothrix species in an endemic area in Brazil

et al. 2020

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Sporotrichosis, a mycosis caused by pathogenic species of the genus Sporothrix, affects diverse species of mammals. Until 2007, Sporothrix schenckii was considered the unique etiologic agent of sporotrichosis. Canine sporotrichosis is a poorly reported disease, and the majority of cases are from Rio de Janeiro, Brazil. There are scarce studies on the characterization of canine isolates of Sporothrix schenckii complex, as well as few antifungal susceptibility data available. The aim of this study was to characterize the clinical isolates of Sporothrix from dogs from Brazil at species level and evaluate their antifungal susceptibility profile. Polyphasic taxonomy was used to characterization at species level (morphological, phenotypical characteristics, and molecular identification). Antifungal susceptibility profiles (amphotericin B, itraconazole, ketoconazole, posaconazole, and terbinafine) were determined using the Clinical and Laboratory Standards Institute broth microdilution method (M38-A2). According to phenotypic identification and molecular analysis, 46 isolates included in this study were identified as S. brasiliensis and one as S. schenckii. Amphotericin B presented the highest minimum inhibitory concentration values, and the other drugs showed effective in vitro antifungal activity. This is the first report of S. schenckii in dogs from Brazil, since S. brasiliensis is the only species that has been described in canine isolates from Rio de Janeiro to date. Nevertheless, no differences were observed in the antifungal susceptibility profiles between the S. brasiliensis and S. schenckii isolates, and it is important to continuously study new canine clinical isolates from Rio de Janeiro, Brazil.

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“…S. brasiliensis, currently regionally restricted to Brazil and Argentina is characterised by its inherent thermotolerability which translates to its ability to cause local and systemic disease [16,17]. This species has been identified as the main cause of feline sporotrichosis epidemics in Brazil, with S. s. sensu stricto isolated in lesser frequency [2,9,13].…”

Section: Epidemiologymentioning

confidence: 99%

Feline sporotrichosis in Asia

Han¹,

Kano

2020

Braz J Microbiol

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Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix pallida identified to cause disease in the cat. Feline sporotrichosis in Asia is mainly reported from Malaysia where a single clonal strain of clinical clade D, Sporothrix schenckii sensu stricto manifesting low susceptibility to major antifungal classes, has been identified as the agent of the disease. Sporothrix globosa has been identified to cause disease from a single cat in Japan while the specific species of agent has not been identified yet for the disease in Thailand. Despite efforts to elucidate and describe the pathogenicity of the agent and the disease it causes, the paucity of data highlights the need for further molecular epidemiological studies to characterize this fungus and the disease it causes in Asia. Its prognosis remains guarded to poor due to issues pertaining to cost, protracted treatment course, zoonotic potential and low susceptibility of some strains to antifungals.

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Sporotrichosis caused by Sporothrix brasiliensis in Argentina: Case report, molecular identification and in vitro susceptibility pattern to antifungal drugs

Cited by 61 publications

References 15 publications

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles of Sporothrix species in an endemic area in Brazil

Feline sporotrichosis in Asia

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