Sporadic Retinoblastoma and Parental Smoking and Alcohol Consumption before and after Conception: A Report from the Children’s Oncology Group

Azary, Saeedeh; Ganguly, Arupa; Bunin, Greta R.; Lombardi, Christina; Park, Andrew S.; Ritz, Beate; Heck, Julia E.

doi:10.1371/journal.pone.0151728

Cited by 27 publications

(28 citation statements)

References 37 publications

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“…Children with bilateral retinoblastoma carry a germline mutation in one allele of a retinal progenitor cell, due to RB1 inheritance from a parent, de novo mutation in parental germline cells or due to a mutation that occurs during very early embryonic development; these children lose the second allele somatically during the pregnancy. Only a small number of studies have reported on maternal smoking and retinoblastoma, but several have reported increased effect estimates . Of these, one study reported an increased risk for maternal smoking in the first trimester and bilateral retinoblastoma (OR = 3.7), and another study an increase with sporadic heritable disease (OR = 2.0), which typically presents as bilateral; the third study did not stratify by laterality.…”

Section: Discussionmentioning

confidence: 99%

“…Only a small number of studies have reported on maternal smoking and retinoblastoma, but several have reported increased effect estimates . Of these, one study reported an increased risk for maternal smoking in the first trimester and bilateral retinoblastoma (OR = 3.7), and another study an increase with sporadic heritable disease (OR = 2.0), which typically presents as bilateral; the third study did not stratify by laterality. Our findings for astrocytoma support those seen in another prospective investigation …”

Section: Discussionmentioning

confidence: 99%

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Smoking in pregnancy and risk of cancer among young children: A population-based study

et al. 2016

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Smoking during pregnancy is a plausible risk factor for childhood cancer, yet previous studies have yielded conflicting results, and few prospective studies have been published. Data on maternal smoking were obtained from California birth certificates. We linked California birth certificates (births 2007–2011) with California Cancer Registry records for childhood cancer cases (diagnosed January 2007 – September 2013) that were ages 5 or younger at diagnosis (N cases=2,021). Controls (N=40,356) were frequency-matched by birth year and randomly selected from birth certificate records. We used unconditional logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI) to assess the association between smoking during pregnancy and childhood cancer. We observed positive associations for gliomas (OR=1.8, 95% CI: 1.0–3.4) and retinoblastoma (OR=3.0, 95% CI: 1.4–6.6), particularly bilateral retinoblastoma (OR=9.4, 95% CI 3.6–24.7) with maternal smoking in pregnancy. Maternal smoking during pregnancy may be a risk factor for retinoblastoma and certain types of childhood brain tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Smoking in pregnancy and risk of cancer among young children: A population-based study

et al. 2016

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“…Detailed methods were previously published 10. Briefly, study approval was obtained by each participating COG institution, Wills Eye Institute, the University of Pennsylvania and the University of California, Los Angeles.…”

Section: Methodsmentioning

confidence: 99%

Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children’s Oncology Group

et al. 2017

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Objectives We examined associations between parental occupational chemical exposures up to 10 years prior to conception and the risk of sporadic retinoblastoma among offspring. Methods In our multicenter study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 years before conception, and mothers one month prior to and during the index pregnancy. An industrial hygienist reviewed all occupational data and assigned an overall exposure score to each job indicating presence of 9 hazardous agents. Results We estimated elevated odds ratios for unilateral and bilateral retinoblastoma among offspring of fathers who were exposed to polycyclic aromatic hydrocarbons (PAHs) or paints in the 10 years prior to conception. However, only for exposure to paints did confidence limits exclude the null for bilateral disease (OR: 8.76, 95% CI: 1.32-58.09). Maternal prenatal exposure to at least one of the 9 agents was related to increased risk of unilateral disease in their children (OR: 5.25, 95% CI: 1.14-24.16). Fathers exposed to at least one of the 9 agents and who were ≥30 years of age were at increased risk of having a child diagnosed with bilateral retinoblastoma (OR: 6.59, 95% CI: 1.34-32.42). Conclusions Our results suggest a role for several hazardous occupational exposures in the development of childhood retinoblastoma.

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“…24, 25 In brief, eligible incident cases were diagnosed with sporadic retinoblastoma on or after July 1 st , 2006 through June 30, 2011 and were diagnosed and/or treated at a COG institution or at the Wills Eye Institute in Philadelphia, PA, USA. Cases were eligible if they were residing in the U.S. or Canada, had access to a home or cellular telephone, and had at least one biological parent who spoke English or Spanish that was available for participation.…”

Section: Methodsmentioning

confidence: 99%

“…Selection of variables for adjustment was based upon literature review as well as associations observed in our data. 23, 25–29 In analyses involving unilateral cases we adjusted for mother’s race (White non-Hispanic, Hispanic, Other), mother’s employment status (Yes/No), whether the father was living at home at the start of pregnancy (Yes/No), and the mother’s age (<29, 30–34, 35+). In analyses of bilateral retinoblastoma, we adjusted for the same variables with the addition of father’s age (<29, 30–34, 35+).…”

Section: Methodsmentioning

confidence: 99%

Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group

Omidakhsh

Ganguly

Bunin

et al. 2017

American Journal of Ophthalmology

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Purpose To examine whether parental pesticide exposure contributes to the development of sporadic retinoblastoma. Design Case-control study. Methods Data were collected by a large multicenter study of sporadic retinoblastoma in which parents of 99 unilateral and 56 bilateral age matched case-control pairs were interviewed by telephone. Retrospective exposure information was collected on the type, location, timing and frequency of residential pesticide use. We used conditional logistic regression analyses to estimate odds ratios for maternal pesticide exposure in the month before or during pregnancy and to assess whether the type of product, and the circumstances under which it was applied, were associated with risk of disease. Results Unilateral retinoblastoma was associated with parental insecticide use (OR, 2.8; CI, 1.1–6.7) and the use of professional lawn or landscape services (OR, 2.8; CI, 1.0–8.2). For bilateral disease we observed large point estimates for several exposures but the small number of cases rendered these results uninformative i.e. resulted in wide confidence intervals. Whether parents used the pesticide inside vs. outside the home did not appear to modify risk estimates for unilateral retinoblastoma (OR, 2.5; CI, 0.9–7.0 vs. OR, 2.5; CI, 1.0–6.5), nor did the type, frequency, timing related to pregnancy or applicator of pesticide used influence estimates to an appreciable degree for disease. Conclusions Our results suggest that parental pesticide exposure before or during pregnancy may play a role in the development of childhood retinoblastoma. Retrospectively collected exposure data introduces the possibility of recall bias, therefore, results should be interpreted cautiously until additional studies are conducted.

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Sporadic Retinoblastoma and Parental Smoking and Alcohol Consumption before and after Conception: A Report from the Children’s Oncology Group

Cited by 27 publications

References 37 publications

Smoking in pregnancy and risk of cancer among young children: A population-based study

Smoking in pregnancy and risk of cancer among young children: A population-based study

Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children’s Oncology Group

Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group

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