Sporadic renal hemangioblastoma: A case report of a rare benign renal tumor

Oberhammer, Lukas; Mitterberger, Michael; Lusuardi, Lukas; Kunit, Thomas; Drerup, Martin; Colleselli, Daniela; Griessner, Hubert; Hager, Martina

doi:10.1002/ccr3.2466

Cited by 9 publications

(21 citation statements)

References 24 publications

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“…The most common and typical radiologic ndings correspond to the last type and show a markedly enhanced small mural nodule attached to a large unenhanced cyst wall [40,41]. There is limited literature describing the imaging ndings of RH, but they report RH as a solid, heterogeneously enhanced mass, which is consistent with our cases [17,22,23].…”

Section: Discussionsupporting

confidence: 85%

“…After screening all the articles in the database, the rst case report of renal hemangioblastoma (RH) was by Nonaka et al in 2007[16]. RH is rare, and no more than 30 cases have been reported, but the content of these articles mainly focused on clinical and pathological research with limited descriptions of radiologic ndings [17][18][19][20][21][22][23][24][25][26][27]. Moreover, there are no descriptions of enhanced magnetic resonance imaging (MRI) ndings of RHs.…”

Section: Introductionmentioning

confidence: 99%

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CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

Liu

et al. 2020

Preprint

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BackgroundHemangioblastoma in the kidney is rare. Although a few renal hemangioblastoma cases have been reported, the content of these articles mainly focused on clinical and pathological research, with minimal descriptions of radiologic findings. Moreover, there are no descriptions of magnetic resonance imaging with enhancement for this condition. We herein report two cases of renal hemangioblastoma with computed tomography and magnetic resonance imaging findings.Case presentationTwo patients presented to our institution due to dull pain of the left abdomen, and a mass in the left kidney was found by ultrasound examination in each case. They had no special family history. Physical examination revealed no obvious tenderness or percussion pain in the renal region and ureteral walking area, and there was no obvious mass. Routine blood and urine tests were normal, and serum tumor markers were negative. No obvious lesions were found on imaging of other body parts. Similar radiologic findings were observed in both cases and mimicked those of cavernous hemangiomas of the liver, including peripheral nodular enhancement in the corticomedullary phase, progressive centripetal enhancement in the nephrographic and delayed phases, and occasional complete “filling in” in the delayed phase. Given the suspicion for renal cell carcinoma, both patients underwent partial nephrectomy. The pathological results showed renal hemangioblastoma.ConclusionsRenal hemangioblastoma is a rare benign tumor that is easily misdiagnosed as clear cell carcinoma. Characteristic computed tomography and magnetic resonance imaging manifestations may improve preoperative diagnostic accuracy to avoid surgery or indicate nephron-sparing surgery.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

Liu

et al. 2020

Preprint

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“…To date, only 26 cases of a RH have been reported in literature thus it is a very rare benign tumor 1,2 occurring as a sporadic tumor and is mostly as an incidental nding. MMT of uterus, also known as carcinosarcoma is also rare and aggressive variety of uterine cancer with high chances of early metastasis.…”

Section: Introductionmentioning

confidence: 99%

Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

Setia

Kumar

Bains

et al. 2020

Preprint

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Introduction: Renal hemangioblastoma (RH) is a very rare benign tumor. Hemangioblastoma most commonly occur in the central nervous system (CNS) and only few cases of RH have been reported as they occur most commonly as asymptomatic masses found incidentally. Mixed Mullerian Tumor (MMT) of the uterus is a rarer and aggressive form of uterine malignancy. The detection of two primary rare tumors incidentally is a rare entity. Case presentation: A 50 years female presented with abnormal uterine bleeding which on endometrial sampling was diagnosed as a rare variety of endometrial cancer i.e., MMT or uterine carcinosarcoma. On preoperative imaging, a renal mass was also detected which was highly vascular and was mimicking Renal Cell Carcinoma (RCC). Fine needle aspiration cytology (FNAC) was done from the renal mass to differentiate between RCC and metastasis but it showed only blood cells. Patient underwent staging laparotomy for endometrial cancer and frozen section examination of the renal mass which was inconclusive with few atypical cells and thus patient underwent radical nephrectomy too. Histopathological examination revealed it to be a RH which is a very rare benign tumor. Discussion: RH is a rare benign tumor which doesn’t require any treatment in majority of the patients. Only 26 cases of RH outside the CNS have been reported till date. MMT is a rare aggressive uterine tumor with an incidence of 1-2 % of all uterine neoplasms, which metastasizes early and thus early identification and treatment is the key. RH needs to be differentiated from RCC to avoid over treatment. Morphological findings are similar in both, preoperative FNAC, PET scan and intraoperative frozen section can be utilized to differentiate in between two in well circumcised tumors and in high suspicion. Occurrence of renal mass as an incidental finding in the preoperative work up of uterine malignancy directed us to the differentials of metastasis or another histologically distinct primary tumor. The presence of two rare primary tumors i.e., RH and MMT in the same patient which are unrelated is a rare entity.

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“…To date, only 14 cases of a sporadic RH have been reported in literature thus making it a very rare benign tumor. 1 It occurs as a sporadic tumor and is mostly an incidental finding. MMT of uterus, also known as carcinosarcoma is another rare and aggressive variety of uterine cancer with high chances of early metastasis.…”

Section: Introductionmentioning

confidence: 99%

Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

Setia

Kumar

Bains

et al. 2020

Preprint

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Introduction Renal hemangioblastoma (RH) is a very rare benign tumor. Hemangioblastoma most commonly occur in the central nervous system (CNS) and only few cases of RH have been reported in literature. They occur most commonly as asymptomatic masses found incidentally. Mixed Mullerian Tumor (MMT) of the uterus is a rarer and aggressive form of uterine malignancy. The detection of two primary rare tumors incidentally is a rare entity. Case presentation A 50 years female patient presented with abnormal uterine bleeding which on endometrial sampling was diagnosed as a rare variety of endometrial cancer i.e., MMT or uterine carcinosarcoma. On preoperative Magnetic resonance imaging (MRI), a renal mass was also detected which was highly vascular and was mimicking Renal Cell Carcinoma (RCC). Fine needle aspiration cytology (FNAC) was done from the renal mass to differentiate between RCC and metastasis but it showed only blood cells. Patient underwent staging laparotomy for endometrial cancer and frozen section examination of the renal mass. Frozen section report was inconclusive with few atypical cells and thus patient underwent radical nephrectomy too. Histopathological examination revealed it to be a RH which is a very rare benign tumor. Discussion Only 14 cases of RH outside the CNS have been reported till date. Occurrence of renal mass as an incidental finding in the preoperative work up of uterine malignancy directed us to the differentials of metastasis or another histologically distinct primary tumor. RH may mimic RCC radiologically. To correctly diagnose RH is important because sporadic RH does not require further treatment and the prognosis is much better than that of RCC. MMT which compromise 1-2% of all uterine neoplasms have higher chance of metastasis than endometroid variety. Conclusion Renal hemangioblastoma is a rare benign tumor which doesn’t require any treatment in majority of the patients. Mixed Mullerian tumor is a rare aggressive uterine tumor which metastasizes early, henceforth early identification and treatment is the key. RH needs to be differentiated from RCC to avoid over treatment. Morphological findings are similar in both, preoperative FNAC, PET scan and intraoperative frozen section can be utilized to differentiate in between two in well circumcised tumors and in high suspicion. The presence of two rare primary tumors i.e., RH and MMT in the same patient which are unrelated is a rare entity.

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Sporadic renal hemangioblastoma: A case report of a rare benign renal tumor

Cited by 9 publications

References 24 publications

CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

CT and MRI Characteristic Findings of Sporadic Renal Hemangioblastoma: Two Case Reports and Review of the Literature

Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

Renal Hemangioblastoma with Mixed Mullerian tumor of endometrium: A tale of two rare primary tumors

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