Sporadic neonatal schizencephaly associated with brain calcification

Al-Alawi, Abeer M.; Al-Tawil, Khalil I.; Al-Hathal, Muneef; Amir, Isam

doi:10.1080/02724930124793

Cited by 5 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two patients with cataracts and schizencephaly raise the possibility of congenital infection, but our study did not have information on these exposures. Calcifications have been noted in the brains of patients with schizencephaly in several instances, and only rarely has infection with CMV been proven [Denis et al, 2000; al‐Alawi et al, 2001; Liang et al, 2002].…”

Section: Discussionmentioning

confidence: 99%

Schizencephaly: Heterogeneous etiologies in a population of 4 million California births

Curry¹,

Lammer²,

Nelson³

et al. 2005

American J of Med Genetics Pt A

133

114

View full text Add to dashboard Cite

Schizencephaly is a rare congenital brain defect characterized by gray matter lined clefts of the cerebral mantle, frequently accompanied by other defects of the CNS such as absence of the corpus callosum. This study in a California population of >4 million births from 1985-2001 found a population prevalence of 1.54/100,000. Among 63 cases, there was an association with young parental age in isolated schizencephaly (RR 3.9 mothers; 5.8 fathers), which was also seen in mothers but not fathers of non-isolated cases (RR 3.2). Monozygotic twins may also be at increased risk for schizencephaly (RR 2.1). One third of cases had a non-CNS abnormality, over half of which could be classified as secondary to vascular disruption, including gastroschisis, bowel atresias, and amniotic band disruption sequence. Other apparent rare causes included chromosomal aneuploidy, non-random associations, and unusual syndromes. Our observations suggest that schizencephaly has heterogeneous etiologies many of which are vascular disruptive in origin.

show abstract

Section: Discussionmentioning

confidence: 99%

Schizencephaly: Heterogeneous etiologies in a population of 4 million California births

Curry¹,

Lammer²,

Nelson³

et al. 2005

American J of Med Genetics Pt A

133

114

View full text Add to dashboard Cite

show abstract

Schizencephaly with occlusion or absence of middle cerebral artery

et al. 2006

View full text Add to dashboard Cite

In a study of 160 infants with prenatal and/or perinatal risk factors for brain damage, we observed three cases of schizencephaly. All cases were unilateral, and the clefts had open lips. In two cases, magnetic resonance angiography showed occlusion or absence of the middle cerebral artery (MCA) on the affected side. Two of the patients, including one with absent flow in the MCA of the affected side, had ipsilateral cerebellar atrophy.

show abstract

Prenatal stroke

Govaert

2009

Seminars in Fetal and Neonatal Medicine

View full text Add to dashboard Cite

The main focus of this chapter is the comprehensive description of the neuropathology, the imaging correlates and underlying mechanisms of prenatal stroke. We describe established prenatal stroke in subgroups similar to postnatal stroke: arterial (forebrain or hindbrain) infarction, venous thrombosis, primary lobar haemorrhage. This longitudinal classification should facilitate the study of risk factors and mechanisms. Forebrain lesions of arterial type present as porencephaly, (hemi)hydranencephaly, multicystic encephalopathy or schizencephaly. Venous prenatal forebrain stroke presents as simple porencephaly (in some of genetic nature) and sinus thrombosis. A list of rare porencephaly-like conditions is added for differentiation from arterial and venous porencephaly. Hindbrain infarctions (so far the only reported variants seem to be of arterial nature) present as brainstem disconnection, focal brainstem destruction, uni- or bilateral cerebellar destruction and focal spinal cord ischaemia. Prenatal intracranial haemorrhage and congenital brain infection should be considered in the differential diagnosis of prenatal stroke.

show abstract

Sporadic neonatal schizencephaly associated with brain calcification

Cited by 5 publications

References 11 publications

Schizencephaly: Heterogeneous etiologies in a population of 4 million California births

Schizencephaly: Heterogeneous etiologies in a population of 4 million California births

Schizencephaly with occlusion or absence of middle cerebral artery

Prenatal stroke

Contact Info

Product

Resources

About