Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review

Abstract

We present here an intriguing case of sporadic renal haemangioblastoma occurring in a 61-year-old male. The tumor consisted of nests of polygonal cells and abundant capillary networks. The neoplastic cells generally showed abundant eosinophilic cytoplasm and prominent eccentric nuclei, resembling the rhabdoid cells. Pronounced intranuclear cytoplasmic pseudoinclusions were another significant feature seen. NSE, a-inhibin and S100 were positive in tumor cells and particularly, focal CD10 expressions were observed. This is possibly the first reported case of a haemangioblastoma showing a rhabdoid phenotype and CD10 immunopositivity. Malignant rhabdoid tumor and renal cell carcinoma with rhabdoid features were probably the most challenging mimics need to be differentiated. The result of focal CD10 staining in our case may further lead to confusion with renal cell carcinoma. To avoid misdiagnosis, more considerations should be attached to the rare neoplasm.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1068858553657049

Effective preparation of a monoclonal antibody against human chromogranin A for immunohistochemical diagnosis

“…Thus it is used as the positive control in measuring the application of 4E5 mAb in clinic IHC experiments. We also used a CgA specific rabbit mAb, SP12, as positive control, which is also accepted as CgA detection [ 22 , 23 ]. Our results showed the effect of 4E5 mAb can even better detect CgA in clinic samples than the cocktail of LK2H10 and PHE5 and SP12 antibody (Fig.…”

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

“…Sporadic renal hemangioblastoma consist of nests of polygonal cells and an abundant capillary network. Immunohistochemical detection of inhibin-alpha and S-100 protein may be helpful [44]. Malignant mixed epithelial and stromal tumor may exhibit rhabdoid morphology.…”

Clinicopathological and Genetic Study of an Atypical Renal Hemangioblastoma△

“…13 Focal positive immunoreaction for CD10 had been reported, 9-10 and a potential explanation was that the tumor was derived from pluripotent mesenchymal cells, but partially acquired some site-specific antigens during pathogenesis. 3,9,14 IHS for EMA positive reaction had been found in some sporadic renal HB, 7,9,11 and CNS hemangioblastomas. [15][16] We also found focal expression of cytokeratin AE1/AE3 in a small percentage of tumor cells (about 5%).…”