SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α
Yubo Pi,
Yang Li,
Qi Yan
et al.
Abstract:Hepatitis B virus (HBV) infection remains a significant public health burden worldwide. The persistence of covalently closed circular DNA (cccDNA) within the nucleus of infected hepatocytes is responsible for the failure of antiviral treatments. The ubiquitin proteasome system (UPS) has emerged as a promising antiviral target, as it can regulate HBV replication by promoting critical protein degradation in steps of viral life cycle. Speckle‐type POZ protein (SPOP) is a critical adaptor for Cul3‐RBX1 E3 ubiquiti… Show more
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