Spontaneus splenic rupture in a patient treated with rivaroxaban

Retracted: Spontaneous rectus sheath haematoma associated with rivaroxaban treatment

“…10,11 Although patients with haemorrhagic pericarditis, pulmonary haemorrhage and spontaneous splenic rupture have been reported, rectus sheath haematoma associated with rivaroxaban has not been reported. 9,10,[11][12][13][14] Rectus sheath haematoma is a rare but important cause of abdominal pain. 15 It is characterized by abrupt severe abdominal pain, immobility of the abdominal wall muscle and a palpable mass.…”

Spontaneous splenic rupture due to rivaroxaban

“…In our case, the interaction between amiodarone, a P-glycoprotein inhibitor and rivaroxaban potentially could have increased the activity of rivaroxaban,11 resulting in major bleeding. An interaction between amlodipine and telmisartan/hydrochlorothiazide was reported in a previous case report 5. There is a higher risk of bleeding when novel anticoagulants are used in combination with antiplatelet agents, especially in the elderly or those with renal dysfunction 12 13.…”

Atraumatic splenic rupture associated with apixaban

“…DOACs, apixaban, rivaroxaban, and dabigatran have all been associated with atraumatic splenic rupture in previous literature. 2–8 This is the third case related to apixaban. 7,8 Apixaban has anticoagulant properties by inhibiting free and bound form of factor Xa.…”

“…Recently, atraumatic splenic rupture has been reported with their increasing use. 2–8 We present a case of a spontaneous splenic rupture with hemorrhagic shock requiring emergent splenic artery embolization and splenectomy in the setting of apixaban use.…”