Spontaneously Occurring Milk Antibodies In Mongoloids

Nelson, Thomas L.

doi:10.1001/archpedi.1964.02090010496008

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…We found that the free and bound fractions of hormonal iodine in the blood were not different in mongols. This confirms the many reports that PBI is normal in this syndrome (Reiss et al, 1965;Simon et al, 1954;Kurland et al, 1957;Rovescalli et al;1964;Saxena and Pry Ies, 1965;Rimoin, 1965;Ferrier and Lemarchand-Beraud, 1965;Marks et al, 1965). Kurland et al, (1957) found a normal butanol-extractable iodine I''" (conversion ratio) in mongolism.…”

Section: Discussionsupporting

confidence: 82%

“…The immune mechanism, itself, may be abnormally responsive in mongolism and contribute to make this a vicious cycle. This is suggested by the finding in mongolism of LATS without hyperthyroidism (Mosier, 1965), the higher incidence of antibodies to milk proteins (Nelson, 1964), and the development of greater intensity of reaction to BCG (Donner, 1954).…”

Section: Discussionmentioning

confidence: 99%

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The Neck‐thigh Radioiodine Ratio in Mongolism*

Mosier

1967

J intellect Disabil Res

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The Neck‐thigh Radioiodine Ratio in Mongolism*

Mosier

1967

J intellect Disabil Res

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“…Infants presenting under the general heading 'neurological' and displaying > 9% histamine release registered sufficiently frequently to deserve further attention. High titres of antibodies to cow's milk in the sera of mongoloid children were demonstrated by Nelson (1964).…”

Section: Discussionmentioning

confidence: 99%

Latent anaphylactic sensitivity of infants to cow's milk proteins

Mclaughlan

Coombs

1983

Clin Experimental Allergy

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Summary Approximately 25% of infants tested released >9% of their blood basophil histamine content in the presence of cow's milk proteins, indicating a degree or level of latent anaphylactic sensitivity to these allergens. Approximately 10% of infants show a considerably higher level of sensitivity (14‐63% histamine release). These findings fulfil an essential tenet of the modified anaphylactic hypothesis for cot‐death.

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“…The exceptionally high values for lymphocyte stimulation by food proteins in children who frequently aspirate food into the lungs may be due to a greater efficiency of antibody production with introduction of antigen into the body by this route compared to the gut (Nelson, 1964;Druck et al, 1969).…”

Section: Lymphocyte Stimulationmentioning

confidence: 99%

In‐vitro responses of leucocytes to food proteins in allergic and normal children: lymphocyte stimulation and histamine release

May

Alberto

1972

Clin Experimental Allergy

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In vitro quantitative methods for determination of antigenic release of histamine from leucocytes and stimulation of small lymphocytes to transformation into blast forms were applied to a study of immunologic responses to food proteins in allergic and nonallergic children. The allergic group was subdivided according to positive or negative reactions to intradermal injection of the food proteins.Significant lymphocyte stimulation by proteins from foods universal in the diets, like cow's milk and eggs, occurred as frequently in non-allergic as allergic children, with or without positive skin tests to the food proteins. Furthermore, the average stimulation among the groups was not significantly different.A soybean protein gave significantly greater stimulation of lymphocytes from allergic children, in whose diets soybean formulae are frequently substituted for cow's milk.Antigenic release of histamine from leucocytes occurs only with leucocytes from skin-test positive persons, and in only about 25-50% of these in the case of food proteins.Neither the procedure for lymphocyte stimulation nor for histamine release from leucocytes, as carried out in this study, will serve to determine unequivocally whether a particular food protein is causing symptoms in question.

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Spontaneously Occurring Milk Antibodies In Mongoloids

Cited by 7 publications

References 8 publications

The Neck‐thigh Radioiodine Ratio in Mongolism*

The Neck‐thigh Radioiodine Ratio in Mongolism*

Latent anaphylactic sensitivity of infants to cow's milk proteins

In‐vitro responses of leucocytes to food proteins in allergic and normal children: lymphocyte stimulation and histamine release

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