Spontaneous Viral Clearance, Viral Load, and Genotype Distribution of Hepatitis C Virus (HCV) in HIV‐Infected Patients with Anti‐HCV Antibodies in Europe

Abstract

More than three-quarters of the HIV- and HCV Ab-positive patients in EuroSIDA showed active HCV replication. Viremia was more frequent in IDUs and, conversely, was less common in HBsAg-positive patients. Of the patients with HCV viremia analyzed, 53% were found to carry HCV genotype 1, and this genotype was associated with greater serum HCV RNA levels.

British HIV Association guidelines for the management of coinfection with HIV‐1 and hepatitis B or C virus 2010

“…Close monitoring of RNA levels may therefore help to identify those individuals who are or are not likely to clear HCV without intervention [230]. After acute infection, it has been suggested that progressive liver damage may occur more rapidly than has been historically reported in coinfected individuals [231].…”

The Cobas AmpliPrep-Cobas TaqMan real-time polymerase chain reaction assay fails to detect hepatitis C virus RNA in highly viremic genotype 4 clinical samples

“…Indeed, the incidence and prevalence of HCV genotype 4 are increasing in the Western world, especially among intravenous drug users, 3 and a recent study has shown that 15% of European patients coinfected with human immunodeficiency virus carry HCV genotype 4. 4 Modeling suggests that HCV genotype 4 could play an important role in the future HCV burden in industrialized countries. 5 Further studies are warranted to assess the frequency of undetected HCV RNA with the CAP-CTM assay.…”

Anti HCV seropozitif kişilerde moleküler HCV RNA test sonuçlarının değerlendirilmesi

“…[14][15][16][17][18][19][20] Kendal ve ark [21] Güneydo¤u Anadolu bölge-sinde yapt›klar› bir araflt›rmada, anti-HCV pozitif hastalar›n %56's›nda HCV-RNA testini pozitif bulmufllard›r. Bu oran bizim araflt›rmam›zdaki sonuçlara göre daha dü-flük düzeydedir.…”