Spontaneous Variability of Cardiac Output in the Dog

Vidt, Donald G.; Hanusek, Gordon E.; Schieve, James F.; Hull, H; Sapirstein, Leo A.

doi:10.1152/ajplegacy.1955.181.2.337

Cited by 14 publications

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“…There does, however, seem to be some justification for assuming that the circulatory status of the animal just previously anesthetized with pentobarbital approximates that of the unanesthetized animal. For example, the cardiac output in dogs anesthetized with pentobarbital is not significantly different from that of the trained unanesthetized animal; 17 the renal plasma flow in the trained unanesthetized dog is not altered by pentobarbital anesthesia;…”

Section: Discussionmentioning

confidence: 96%

Effect of Ether Anesthesia on the Cardiac Output, Blood Pressure, and Distribution of Blood Flow in the Albino Rat

Vidt

Bredemeyer

Sapirstein

et al. 1959

Circulation Research

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Rats anesthetized with ethyl ether were compared with rats anesthetized with sodium pentobarbital from the standpoint of cardiac output, peripheral resistance and regional blood flow. Cardiac output was measured by the indicator-dilution technic; regional blood flow was determined by the indicator-fractionation technic employing Rb 86 or I 131 -antipyrine. The cardiac output is one and a half times as great in ether anesthesia as in pentobarbital anesthesia; the peripheral resistance is about two-thirds as great with ether. Compared to pentobarbital, ether increases myocardial, cerebral, and carcass blood flow, while decreasing renal, splanchnic and cutaneous blood flow. The pronounced difference in the cardiovascular effects of the two agents indicates the need for caution in the interpretation of experiments in which cardiovascular measurements are made under anesthesia.

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Section: Discussionmentioning

confidence: 96%

Effect of Ether Anesthesia on the Cardiac Output, Blood Pressure, and Distribution of Blood Flow in the Albino Rat

Vidt

Bredemeyer

Sapirstein

et al. 1959

Circulation Research

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“…In one animal the calculated PVR was on two separate occasions 1-0 and 2-0; in another animal 2-4 and 5 0. Later work has confirmed the instability of the cardiac output in dogs both in anaesthetized and in unaneesthetized trained animals [Vidt, Hanusek, Schieve, Hull and Sapirstein, 1955]. Barger, Richards Metcalfe and Gunther [1957] and Severinghaus and Stuffel [1957] have shown that the cardiac output depends upon posture.…”

Section: Experiments On Collapsed Lungsmentioning

confidence: 96%

An Analysis of Active and Passive Effects on the Pulmonary Vascular Bed in Response to Pulmonary Nerve Stimulation

Daly

1961

Exp Physiol

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In an isolated innervated perfused left lung preparation of the dog the calculated pulmonary vascular resistance overlapped the upper limit of the range reported by others for normal resting animals.The increase in pulmonary vascular resistance in response to stimulation of pulmonary nerves in which pulmonary vasoconstrictor fibres and bronchoconstrictor fibres are intermingled was due to vasoconstriction in the pulmonary vascular bed proper. This response was not appreciably altered or influenced by passive effects due to accompanying bronchoconstriction or changes in the bronchial circulation.PULMONARY vasomotor responses to nerve stimulation in lungs under controlled ventilation and perfusion have been demonstrated in the absence of passive systemic vascular and bronchomotor effects [for literature see Daly, 1958]. Two main criticisms have been levelled against such experiments; the first on the grounds that the techniques necessary to control and measure all variables lead to such small blood flows that the perfused lungs only represent fragments of lung tissue [Hamilton, 1951]. In the experiments reported here improvements in technique and in the nature of the perfusate have reduced the pulmonary vascular resistance (PVR) to within the upper range of the values found by others in normal dogs. The second criticism is that vasomotor responses to nerve stimulation are secondary to change in lung hindrance due to alterations in intrapulmonary pressure caused by stimulation of bronchoconstrictor nerve fibres [Wagner, 1935; Rodbard, 1953]. This problem would be greatly clarified if a quantitative relationship could be established between the PVR responses to nerve stimulation under conditions in which all passive effects were excluded, with those in which bronchial circulation perfusion and/or accompanying bronchomotor responses were a source of potential passive effects on the PVR. This was the main aim of the investigation. It included studies of pulmonary vascular resistance responses to nerve stimulations in ventilated, collapsed and statically inflated lungs in which bronchomotor effects were measured by recording changes in tidal air, in intrapulmonary volume and in intracheal pressure respectively. METHODS Dogs, 160-20-6 kg. weight, premedicated with morphine hydrochloride (1-2 mg./kg. subcutaneously) were exsanguinated and the isolated left lung prepared for perfusion of the bronchial and pulmonary circulations with autologous blood by * Present address: University Laboratory of Physiology, Oxford.

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Eine Isotopenverd�nnungsmethode zur gleichzeitigen Messung von Herzzeitvolumen und Coronardurchflu�

Frimmer

Lange

Resag

1961

Naunyn - Schmiedebergs Arch

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Spontaneous Variability of Cardiac Output in the Dog

Cited by 14 publications

References 0 publications

Effect of Ether Anesthesia on the Cardiac Output, Blood Pressure, and Distribution of Blood Flow in the Albino Rat

Effect of Ether Anesthesia on the Cardiac Output, Blood Pressure, and Distribution of Blood Flow in the Albino Rat

An Analysis of Active and Passive Effects on the Pulmonary Vascular Bed in Response to Pulmonary Nerve Stimulation

Eine Isotopenverd�nnungsmethode zur gleichzeitigen Messung von Herzzeitvolumen und Coronardurchflu�

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