Spontaneous tumour lysis syndrome

Kekre, Natasha; Djordjevic, Bojana; Touchie, Claire

doi:10.1503/cmaj.111251

Cited by 52 publications

(60 citation statements)

References 19 publications

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“…TLS is not expected to occur in cases of chemotherapy non-sensitive solid tumours, even when the tumour size is large. However, it has a poor prognosis when it does occur [3]. One remarkable aspect regarding TLS is the presence of liver metastases (with or without liver function abnormalities) in most patients with solid tumours, just as we observed in our case.…”

Section: Discussionsupporting

confidence: 73%

“…As a result of such anomalies the patient will often develop clinical outcomes such as renal failure and, occasionally, cardiac arrhythmias. Although TLS is usually discovered upon initiation of chemotherapy, more rarely, and particularly in cases where a fast-growing tumour is present, it can be seen before treatment as well, as a result of the malignant cells' self-lysis [2] [3]. If the required measures are not taken and the existing clinical entity is not treated immediately, metabolic anomalies of cancer patients can result in renal impairment, cardiac arrhythmia, neurological complication and sudden death.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report

Kalkan¹,

Almalı²,

Gokmen³

et al. 2018

JCT

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Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report

Kalkan¹,

Almalı²,

Gokmen³

et al. 2018

JCT

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“…Occasionally, TLS can also occur spontaneously without any form of anticancer therapy. 5,6 TLS can be clinically characterized by the rapid development of hyperuricaemia, hyperkalaemia, hyperphosphataemia and consequential hypocalcaemia and acute renal failure. [1][2][3] Although it can occur spontaneously, TLS most commonly occurs within 6-72 h of initial cancer treatment, and nephropathy associated with hyperuricaemia usually is the major cause of acute renal failure.…”

Section: What Is Known and Objectivementioning

confidence: 99%

Efficacy and cost of single-dose rasburicase in prevention and treatment of adult tumour lysis syndrome: a meta-analysis

et al. 2013

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Single-dose rasburicase (SDR) for adult cancer patients with hyperuricaemia or at high risk for TLS demonstrated better response rate and stronger control of uric acid level compared with allopurinol. SDR response rate was not inferior to that of DDR, and the standard-dose SDR generates more cost savings compared with the DDR. It suggests that the single-dose rasburicase is clinically effective and cost efficient for the prophylaxis of high-risk TLS and the treatment of hyperuricaemia in adult patients with cancer. Additional randomized control studies are needed to confirm the findings of this meta-analysis study.

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“…Spontaneous TLS has been described in solid tumors and hematological tumors [6, 7]. Saravu et al reported a case having MM with spontaneous TLS, following a compression fracture of the L2 vertebrae.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

Hüzmelí

Eliaçık

Sağlam

et al. 2016

Case Reports in Medicine

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The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a compression fracture of the T-12 vertebrae. While serum uric acid and phosphorous levels were high, low calcium levels were identified. There were also acute kidney injury and metabolic acidosis. Upon the diagnosis of TLS, she was treated with hydration, allopurinol, sodium bicarbonate, and calcium gluconate. The improvement of her laboratory data was observed. We submitted this case in order to draw attention to the presentation of MM with spontaneous TLS.

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Spontaneous tumour lysis syndrome

Cited by 52 publications

References 19 publications

Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report

Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report

Efficacy and cost of single-dose rasburicase in prevention and treatment of adult tumour lysis syndrome: a meta-analysis

Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

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