Spontaneous Tumors in Sweet Clover

Littau, Virginia C.; Black, L. M.

doi:10.2307/2438358

Cited by 14 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spontaneous tumor formation has been long reported to occur in a variety of plant species and to affect different organs, including the leaves of Thea sinensis, cotyledons of Pharbitis nil, lateral shoots of Picea glauca and Sequoia sempervirens, pods of Pisum sativum, and the ovaries of Sorghum bicolor (reviewed in Ahuja 1998), but the causes of the formation of these tumors have not been studied. Moreover, spontaneous tumors have been identified in the inbred lines of Melilotus alba (Littau and Black 1952) and Raphanus sativus (Narbut 1967) and interspecific hybrids of Nicotiana (Smith 1988). Finally, several groups of monogenic tumorous mutants were obtained in Arabidopsis (Faure et al 1998;Frank et al 2002;Iwai et al 2002;Sieberer et al 2003;Krupkova et al 2007).…”

Section: Spontaneous Tumors: Fatal Errorsmentioning

confidence: 99%

See 1 more Smart Citation

Plant tumors: a hundred years of study

Додуева

Lebedeva

Kuznetsova

et al. 2020

Planta

View full text Add to dashboard Cite

show abstract

Section: Spontaneous Tumors: Fatal Errorsmentioning

confidence: 99%

“…The formation of spontaneous tumors was noted in inbred lines of Melilotus alba (Littau and Black 1952) and Raphanus sativus (Narbut 1967), but only the latter have become the subject of study. A collection of radish (Raphanus sativus var.…”

Section: Tumorous Inbred Linesmentioning

confidence: 99%

Plant tumors: a hundred years of study

Додуева

Lebedeva

Kuznetsova

et al. 2020

Planta

View full text Add to dashboard Cite

show abstract

“…Recent data suggest that the tumorous transformation in plants is mediated by an interaction between specific genetic factors and endogenous physiological condi-tions. Single genes (Nuttall and Lyall, 1964), integration of foreign genome,: (Littau and Black, 1952;Thomashow et al, 1980), fixation during evolution of specific genotypes (Buiatti and Bennici, 1970) and interaction between plant genomes in interspecific hybrids (Naf, 1958) may all determine favorable backgrounds for tumor formation. In most of these cases the plant genetic structure seems responsible for lowering the hormonal threshold needed for cell proliferation as shown by in vitro studies (Bayer and Ahuja, 1968).…”

Section: Introductionmentioning

confidence: 99%

A comparison of genome modifications leading to genetic and epigenetic tumorous transformation in Nicotiana spp. tissue cultures

Durante¹,

Geri²,

Buiatti³

et al. 1986

Dev. Genet.

View full text Add to dashboard Cite

A single system is presented, where both genetic and epigenetic control of tumor induction can be studied at the same time. This system is offered by the amphidiploid tumorous hybrid Nicotiana gluuca X N . langsdo@i, a nontumorous mutant of it and the nontumorous parent species N . glauca and N . langsdofii. The aim of the present paper is to compare long-term in vitro cultures of tumorous (genetic and habituated), and nontumorous strains, through the characterization of their genomes according to several physico-chemical parameters. The data reported show that both qualitative and quantitative differences in DNA complexity are correlated with the tumorous transformation. Particularly, a high degree of mismatching between the DNAs of the tumorous and nontumorous hybrids and the lack, in the second genotype (nontumorous), of three DNA peaks in Agf-Cs2S04 analytical ultracentrifugation profile seem to support the hypothesis, suggested in a previous paper, of the presence, in the nontumorous mutant, of a gross chromosomal rearrangement, probably a deletion. Amplification and underreplication of specific sequences also seemed to be correlated with changes from the normal to the tumorous state, highly repetitive sequences being present in higher amounts in the normal strains and in the habituated N . glauca than in the case of the tumorous hybrid.Finally, DNA bound ion contents were found to be strikingly higher in tumorous than in nontumorous tissues. The results are discussed in the frame of the general hypothesis of high somatic genomic plasticity in plants.

show abstract

DNA heterogeneity and genetic control of tumorigenesis in nicotiana tumorous and nontumorous genotypes

Durante¹,

Geri²,

Buiatti³

et al. 1982

Dev. Genet.

View full text Add to dashboard Cite

The possible relevance of changes in amounts of highly repetitive DNA sequences for plant differentiation and dedifferentiation processes has been suggested in several cases. Data are lacking however on 1) the genetic control of these phenomena and 2) cause-effect relationships between DNA amplification and specific ontogenetic patterns.The present study was carried out on a Nicotiana genetic system consisting of the tumorous amphidiploid N glauca x N langsdorffii, a nontumorous mutant of it, their F,, and a backcross to the tumorous parent. Backcross segregation ratios were shown to be compatible with a "single gene" hypothesis, the F, plant being nontumorous but showing a low percentage of tumors induced by wounds, 6-azauracil or X-rays.In vitro studies of excised pith tissue grown on Linsmaier and Skoog medium for different periods of time showed the presence, confirmed by cytological analyses, of amplification of highly repetitive sequences only in the nontumorous stock, as judged by reassociation experiments in the first 24-96 hours of culture. CsCl analytical ultracentrifugation of those sequences showed the appearance in the same stock of a heavy DNA satellite (density = 1.721 g d m l ) , whose presence was also confirmed by derivative melting curves. Amplification seemed to be essential for the initiation of cell division, which was completely inhibited in the nontumorous genotype and partially influenced in the F, by incorporation during the critical period (24-96 hours of the primary explant) of 5-bromo-2'-deoxy-uridine.The results are discussed in terms of an hypothesis of an integrated gene-controlled, hormone-mediated regulatory system of cell proliferation involving changes in target repetitive DNA sequences.

show abstract

Spontaneous Tumors in Sweet Clover

Cited by 14 publications

References 0 publications

Plant tumors: a hundred years of study

Plant tumors: a hundred years of study

A comparison of genome modifications leading to genetic and epigenetic tumorous transformation in Nicotiana spp. tissue cultures

DNA heterogeneity and genetic control of tumorigenesis in nicotiana tumorous and nontumorous genotypes

Contact Info

Product

Resources

About