Spontaneous Symmetry Breaking: The Case of Crazy Clock and Beyond

Pagnacco, Maja C.; Maksimović, Jelena P.; Daković, Marko; Bokic, Bojana; Mouchet, Sébastien R.; Verbiest, Thierry; Caudano, Yves; Kolarić, Branko

doi:10.3390/sym14020413

Cited by 3 publications

(6 citation statements)

References 32 publications

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“…As previously published, 7,10,14 the State I → State II transition is essentially irreproducible in time (as its "crazy-clock" name indicates). Surprisingly, this crazy-clock behavior is preceded by a strongly reproducible oscillatory dynamics (at 25 °C, the oscillatory period lasts 240 s, with 33 oscillations), which happens before solid iodine formation, i.e., before the State I → State II transition.…”

Section: ■ Results and Discussionmentioning

confidence: 90%

“…Nonlinear systems are highly sensitive to the concentration of reactants, the geometries of the reaction vessel, mixing conditions, and external influences like light and temperature. ,− Up to now, the time evolution of nonlinear chemical systems has been successfully monitored by potentiometric methods. − However, the electrodes immersed in the solution could give rise to additional effects like catalytic effect, “dead volume” effect (i.e., when diffusion of chemical species is a controlling factor for the reaction), and a lot of other processes highly dependent on the nature of the working electrode. , Furthermore, the main reactant, hydrogen peroxide, could be decomposed on the platinum electrode, which is widely used in potentiometric measurements of oscillatory reactions. In addition, many details of a complex redox system are not fully understood .…”

Section: Resultsmentioning

confidence: 99%

“…18−21 However, the electrodes immersed in the solution could give rise to additional effects like catalytic effect, "dead volume" effect (i.e., when diffusion of chemical species is a controlling factor for the reaction), and a lot of other processes highly dependent on the nature of the working electrode. 10,19 Furthermore, the main reactant, hydrogen peroxide, could be decomposed on the platinum electrode, which is widely used in potentiometric measurements of oscillatory reactions. In addition, many details of a complex redox system are not fully understood.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Therefore, it is crucial to develop methods that offer new insight into the physics of oscillatory reactions, the pattern formations at the nanoscale, and their links with macroscopic behavior. In this article, we analyzed a nonequilibrium chemical system, an oscillatory Briggs–Rauscher (BR) reaction accompanied with phase transition, i.e., solid iodine formation. , Under the applied experimental conditions, after the BR oscillatory period, two states are observed: State I (low iodide and iodine concentration) and State II (high iodide and iodine concentration, with solid iodine formation). A sudden transition from State I to State II, so-called crazy-clock behavior , is accompanied by a liquid–solid iodine phase transition. ,, This process proved to be an ideal model for implementing a new holographic approach.…”

Section: Introductionmentioning

confidence: 99%

“…A sudden transition from State I to State II, so-called crazy-clock behavior, is accompanied by a liquid−solid iodine phase transition. 7,10,11 This process proved to be an ideal model for implementing a new holographic approach. In addition to holographic observations, potentiometric measurements are performed, as a comparison to assess the performance of our method.…”

Section: ■ Introductionmentioning

confidence: 99%

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Stochastic Phase Transition Dynamics in Nonequilibrium System: Holographic Study

et al. 2023

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This paper presents a holographic study of the phase transition that occurs in a nonequilibrium system. The chosen model is a unique Briggs–Rauscher oscillatory reaction that, first, follows a deterministic pattern (namely, an oscillatory behavior) and, later, exhibits a phase transition occurring randomly and without any known link with the previous deterministic state. The presented research opens up a new way to reveal complex chemical phenomena and dynamics in situ, without disturbing significantly the nonequilibrium system and its pathways. Simultaneously, it unfolds a new route for applications of interferometric methods in different areas of materials science. Under the applied conditions, we show that the holographic method is more sensitive to the phase transition dynamics than the commonly used potentiometric method.

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Section: ■ Results and Discussionmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Stochastic Phase Transition Dynamics in Nonequilibrium System: Holographic Study

et al. 2023

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From Pathogens to Cancer: Are Cancer Cells Evolved Mitochondrial Super Cells?

et al. 2023

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Life is based on a highly specific combination of atoms, metabolism, and genetics which eventually reflects the chemistry of the Universe which is composed of hydrogen, oxygen, nitrogen, sulfur, phosphorus, and carbon. The interaction of atomic, metabolic, and genetic cycles results in the organization and de-organization of chemical information of that which we consider as living entities, including cancer cells. In order to approach the problem of the origin of cancer it is therefore reasonable to start from the assumption that the sub-molecular level, the atomic structure, should be the considered starting point on which metabolism, genetics, and external insults eventually emanate. Second, it is crucial to characterize which of the entities and parts composing human cells may live a separate life; certainly, this theoretical standpoint would consider mitochondria, an organelle of “bacteria” origin embedded in conditions favorable for the onset of both. This organelle has not only been tolerated by immunity but has also been placed as a central regulator of cell defense. Virus, bacteria, and mitochondria are also similar in the light of genetic and metabolic elements; they share not only equivalent DNA and RNA features but also many basic biological activities. Thus, it is important to finalize that once the cellular integrity has been constantly broken down, the mitochondria like any other virus or bacteria return to their original autonomy to simply survive. The Warburg’s law that states the ability of cancers to ferment glucose in the presence of oxygen, indicates mitochondria respiration abnormalities may be the underlying cause of this transformation towards super cancer cells. Though genetic events play a key part in altering biochemical metabolism, inducing aerobic glycolysis, this is not enough to impair mitochondrial function since mitochondrial biogenesis and quality control are constantly upregulated in cancers. While some cancers have mutations in the nuclear-encoded mitochondrial tricarboxylic acid (TCA) cycle, enzymes that produce oncogenic metabolites, there is also a bio-physic pathway for pathogenic mitochondrial genome mutations. The atomic level of all biological activities can be considered the very beginning, marked by the electron abnormal behavior that consequently affects DNA of both cells and mitochondria. Whilst the cell’s nucleus DNA after a certain number of errors and defection tends to gradually switch off, the mitochondria DNA starts adopting several escape strategies, switching-on a few important genes that belong back at their original roots as independent beings. The ability to adopt this survival trick, by becoming completely immune to current life-threatening events, is probably the beginning of a differentiation process towards a “super-power cell”, the cancer cells that remind many pathogens, including virus, bacteria, and fungi. Thus, here, we present a hypothesis regarding those changes that first begin at the mitochondria atomic level to steadily involve molecular, tissue and organ levels in response to the virus or bacteria constant insults that drive a mitochondria itself to become an “immortal cancer cell”. Improved insights into this interplay between these pathogens and mitochondria progression may disclose newly epistemological paradigms as well as innovative procedures in targeting cancer cell progressive invasion.

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