Spontaneous splenic rupture during induction chemotherapy for acute myeloid leukemia

Zeidan, Amer M.; Mitchell, Mhairi; Khatri, Rina; Itani, Doha; Boikos, Sosipatros A.; Bose, Sonali; Lipsett, Pamela A.; Efron, David T.; King, Karen E.; Gerber, Jonathan M.; DeZern, Amy E.

doi:10.3109/10428194.2013.796060

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Factors increasing the risk for splenic rupture are chemotherapy, male gender and a large spleen [ 8 ]. Surprisingly, splenic rupture can occur after initiation of chemotherapy even in the setting of a normal spleen, which is supposed to be due to release of lytic substance from the dying cells [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous rupture of the spleen as a result of primary splenic lymphoma

2016

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Spontaneous rupture of the spleen is a true surgical emergency that requires immediate management to prevent rapid exsanguination. It occurs mostly as a result of splenic infiltration by infectious or haematological diseases. We present a case of a 79-year-old male who was admitted to our emergency department with 3 days history of feeling unwell, abdominal pain, and dizziness, with no history of trauma. He was hypotensive, but all other observations were within normal limits. Examination revealed abdominal tenderness, mainly on the left side, with no palpable organs or masses. Computed tomography scan showed an abnormal spleen with signs of intraabdominal bleeding; emergency splenectomy was performed successfully. Histological examination showed infiltration of the spleen by diffuse large B cell lymphoma, which was later confirmed to be primary. The patient went through an uneventful post-operative recovery, and remains disease free so far.

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Section: Discussionmentioning

confidence: 99%

Spontaneous rupture of the spleen as a result of primary splenic lymphoma

2016

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“…The disseminated intravascular coagulation may be a result rather than a cause of SSR, as suggested by another report. [3] …”

Section: Case Reportmentioning

confidence: 99%

“…In hematological settings, different etiologies have been reported, but they are uncommon in acute myeloid leukemia (AML), especially after induction chemotherapy initiation. [1] , [2] , [3] Several clinical associations have been reported, but no clear risk factor has been identified. Prompt imaging diagnosis is required to reduce morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous splenic rupture during induction therapy in acute myeloid leukemia: An unusual case.

Tavarozzi

Borra

Catania

et al. 2021

Radiology Case Reports

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Spontaneous splenic rupture (SSR) is a rare life-threatening emergency. In hematological settings, it is uncommon in acute myeloid leukemia (AML). We report an atypical case of SSR in a 73-year-old male with AML where a prompt imaging ultrasound assessment played a key role. Performed noninvasively at bedside, it allowed rapid imaging diagnosis, confirming its essential role even in the presence of hematological disease.

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“…Spontaneous splenic rupture, also referred to as atraumatic splenic rupture, is an uncommon serious complication of acute leukemia, with very few reported cases since Rokitansky first described spontaneous rupture of the spleen in a patient with leukemia in 1861 (1)(2)(3)(4)(5)(6)(7). Although the precise occurrence of spontaneous splenic rupture is not known, its actual morbidity may be higher due to the difficulty of diagnosis in the past.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report

Zhang¹,

Zhang²,

Chen³

et al. 2016

Molecular and Clinical Oncology

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Abstract. Spontaneous splenic rupture, also referred to as atraumatic splenic rupture, is a rare but life-threatening emergency condition. Without timely diagnosis and treatment, the mortality rate of splenic rupture approaches 100%. The etiology of atraumatic splenic rupture varies; it is reportedly associated with neoplasms or splenic infection, but is rarely encountered in patients with both conditions. We herein report the case of a 58-year-old male patient with acute myeloid leukemia (AML) complicated by splenic tuberculosis (TB), who presented with spontaneous rupture of the spleen. Pathological examination of the resected spleen revealed multifocal granulomatosis with caseous necrosis. However, with timely diagnosis and surgical intervention, the patient recovered successfully and is currently on consolidation therapy. To the best of our knowledge, this is the first case of spontaneous splenic rupture in AML with splenic TB. The relevant literature on spontaneous splenic rupture was also reviewed and the potential etiology and treatment were discussed.

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Spontaneous splenic rupture during induction chemotherapy for acute myeloid leukemia

Cited by 9 publications

References 13 publications

Spontaneous rupture of the spleen as a result of primary splenic lymphoma

Spontaneous rupture of the spleen as a result of primary splenic lymphoma

Spontaneous splenic rupture during induction therapy in acute myeloid leukemia: An unusual case.

Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report

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