Spontaneous Splenic Rupture Caused by<i>Babesia microti</i>Infection

Kuwayama, David P.; Briones, Renato J.

doi:10.1086/587175

Cited by 36 publications

(21 citation statements)

References 9 publications

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“…Patients who are elderly, IC, or asplenic will experience similar symptoms but with increased severity. An isolated case of splenic rupture due to a B. microti infection has also been reported (340). In ICT patients, Babesia infections can persist for many months, even if treatment has been initiated (335,574).…”

Section: Babesia Sppmentioning

confidence: 98%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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Section: Babesia Sppmentioning

confidence: 98%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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“…CT scans demonstrated splenic laceration in both patients, and they subsequently underwent emergent splenectomy due to worsening hemodynamic instability. Parasite count was noted to be 5% for the 61 year-old male, and not reported for the other[2,3]. In comparison to the two patients requiring operative invention, our patient had a slightly lower parasite count and received platelet transfusions.…”

Section: Discussionmentioning

confidence: 56%

“…There are several reports of splenic rupture as well as splenic infarction in the literature[2,3,20]. However, there are no reports describing successful non-operative management of significant rupture.…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Successful non-operative management of spontaneous splenic rupture in a patient with babesiosis

et al. 2011

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BackgroundBabesiosis is a zoonotic disease transmitted by the Ixodes tick species. Infection often results in sub-clinical manifestations; however, patients with this disease can become critically ill. Splenic rupture has been a previously reported complication of babesiosis, but treatment has always led to splenectomy. Asplenia places a patient at greater risk for overwhelming post-splenectomy infection from encapsulated bacteria, Lyme disease, Ehrlichia as well as Babesia microti. Therefore, avoiding splenectomy in these patients must be considered by the physician; particularly, if the patient is at risk for re-infection by living in an endemic area.Case PresentationA 54 year-old male from the northeast United States presented with left upper quadrant abdominal pain associated with fever, chills, night sweats and nausea. A full evaluation revealed active infection with Babesia microti and multiple splenic lacerations. This patient was successfully treated with appropriate pharmacological therapy and non-operative observation for the splenic injury.ConclusionPatients diagnosed with Babesia microti infection are becoming more common, especially in endemic areas. Although clinical manifestations are usually minimal, this infection can present with significant injuries leading to critical illness. We present the successful non-operative treatment of a patient with splenic rupture due to babesiosis infection.

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“…In reviewing the literature we found 11 cases with this complication. Table 3 summarizes these cases [40][41][42][43][44][45][46][47]. Accordingly, we conclude that babesiosis can cause splenic rupture, just like malaria which is a well-documented cause of this pathology.…”

Section: Discussionmentioning

confidence: 90%

Hematologic Manifestations of Babesiosis

Akel

Mobarakai

2018

Ann Clin Lab Res

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Background: Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in the human host that is attracting attention worldwide. Most cases of human babesiosis are reported in the United States and Europe. The disease is caused by the protozoa of the genus Babesia, which invade human erythrocytes and lyse them causing a febrile hemolytic anemia. The infection is usually asymptomatic or self-limited in the immunocompetent host, or follows a persistent, relapsing, and/or life threatening course with multi-organ failure, mainly in the splenectomized or immunosuppressed patients. Hematologic manifestations of the disease are common. They can range from mild anemia, to severe pancytopenia, splenic ruture, disseminated intravascular coagulopathy (DIC), or even hemophagocytic lymphohistiocytosis (HLH).

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Spontaneous Splenic Rupture Caused byBabesia microtiInfection

Cited by 36 publications

References 9 publications

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Case Report: Successful non-operative management of spontaneous splenic rupture in a patient with babesiosis

Hematologic Manifestations of Babesiosis

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