Spontaneous rupture of the uterus in the third trimester after high-intensity ultrasound ablation in adenomyosis: A case report

Wu, Siyun; Li, Jun; Jiang, Libin; Yang, Lijun; Ye, Han

doi:10.3389/fmed.2022.966620

Cited by 5 publications

(3 citation statements)

References 19 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, two papers reported 2 cases of uterine rupture in pregnancy after HIFU treatment for adenomyosis due to the adenomyotic lesion was over treated. Fortunately, both patients recovered well and the neonates were healthy 25,26 . In this study, the NPV ratio for adenomyosis in patients who conceived after HIFU was 42.0 +-23.2%.…”

Section: Discussionmentioning

confidence: 93%

Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

Ma,

Briones,

Zou

et al. 2024

Preprint

View full text Add to dashboard Cite

Objectives: To analyze the factors influencing pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound (HIFU) treatment. Design: A retrospective study. Setting: Department of Gynaecology in a single centre in China. Population: Patients with adenomyosis under the age of 45 years who had a desire for future fertility. Methods: Pregnancy outcomes and factors influencing pregnancy outcomes were analyzed using multivariate regression analysis and survival analysis Main Outcome Measures: The improvement of symptoms and reproductive related information were recorded during the average follow-up time of 73.8 ± 28.6 months. Results: After HIFU, 100 of 231 (43.3%) patients became pregnant within 96 months. Among them, 77 conceived naturally, and 23 patients conceived by in vitro fertilization and embryo transfer (IVF-ET). In the 108 infertile patients, 31 (28.7%) became pregnant. At the end of follow-up, 70 successfully delivered 71 healthy babies. No uterine rupture occurred during pregnancy and delivery. The cumulative pregnancy rate increased faster in the IVF-ET group than that in the natural pregnancy group. Patients with pelvic adhesion and infertility history had lower pregnancy possibility than patients without pelvic adhesion and infertility history (OR<1, P<0.05). Patients with small adenomyotic lesion volume had a greater possibility of pregnancy than that of patients with large lesion volume (OR < 1, P < 0.05). Conclusions: HIFU has a positive effect on fertility, and IVF-ET seems to have improved the pregnancy rate of the patients with adenomyosis treated with HIFU. Pelvic adhesion, infertility history, and adenomyotic lesion volume were factors affecting pregnancy.

show abstract

Section: Discussionmentioning

confidence: 93%

Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

Ma,

Briones,

Zou

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…A study found that HIFU treatment for adenomyosis does not increase the risk of uterine rupture [22]. We reviewed the literature and found only two patients who had uterine rupture during delivery after HIFU treatment [23,24]. However, the correlation between HIFU treatment for adenomyosis and uterine rupture cannot be explained.…”

Section: Discussionmentioning

confidence: 98%

High Intensity Focused Ultrasound Ablation for Juvenile Cystic Adenomyosis: Two Case Reports and Literature Review

et al. 2023

View full text Add to dashboard Cite

Cystic adenomyosis is a rare type of uterine adenomyosis, mainly seen in young women, which is often characterized by severe dysmenorrhea. The quality of life and reproductive function of young women could be affected by misdiagnosis and delayed treatment. At present, there are no universal guidelines and consensus. We report two cases of patients with cystic adenomyosis in juveniles treated with high-intensity focused ultrasound (HIFU) ablation. In the first case, magnetic resonance imaging (MRI) indicated a cystic mass of 2.0 cm × 3.1 cm × 2.4 cm in the uterus. After she underwent HIFU treatment, her pelvic MRI showed a mass of 1.1 × 2.4 cm in size, and her dysmenorrhea symptoms gradually disappeared. In the second case, a pelvic MRI indicated a 5.1 cm × 3.3 cm × 4.7 cm cystic mass in the uterus. After she underwent HIFU and combined four consecutive cycles of GnRH-a treatment, the lesion shrunk 1.2 cm ×1.4 cm × 1.6 cm, without dysmenorrhea. Simultaneously, the report reviewed 14 cases of juvenile cystic adenomyosis over the last ten years. HIFU or HIFU-combined drugs were safe and effective in treating juvenile cystic adenomyosis, but multicenter and prospective studies may be necessary to validate this in the future.

show abstract

“…In this research, we characterized the presence of CTLs, Tc17, Th1, and ThGM cells in patients with focal or diffuse AM before and after focused ultrasound ablation surgery (FUAS). FUAS is a noninvasive procedure that uses high‐intensity ultrasound to generate an instant temperature increase to induce coagulation necrosis of the targeted lesion [24]. We found that these T cell subsets were increased in the blood and AM tissues of patients especially those with diffusive AM.…”

Section: Introductionmentioning

confidence: 87%

Cytotoxic T Lymphocytes, Tc17 Cells, Th1 Cells, and ThGM Cells are Increased in the Blood and Ectopic Endometrium of Patients With Adenomyosis

Zhang,

Zhu,

Che

et al. 2024

American J Rep Immunol

View full text Add to dashboard Cite

ProblemAdenomyosis (AM) is associated with immune response and inflammation. However, the role of T cell subsets in AM development has not been thoroughly understood.Method of StudyPatients with focal or diffuse AM were recruited. Serum cytokines were quantified by enzyme‐linked immunosorbent assay (ELISA). Different T cell subsets in the blood and ectopic endometrium were determined by flow cytometry.ResultsSerum interleukin‐6 (IL‐6) and macrophage‐colony‐stimulating factor (GM‐CSF) were increased in patients with focal or diffuse AM before focused ultrasound ablation surgery (FUAS), but not after FUAS. Compared with the healthy control, the frequencies of CD8+ interferon‐gamma (IFN‐γ)‐expressing cytotoxic T lymphocytes (CTLs), interleukin‐17A (IL‐17A)‐expressing Tc17 cells, CD4+ T helper 1 (Th1) cells, and GM‐CSF‐expressing T helper (ThGM) cells were up‐regulated in the blood of patients with AM, especially those with diffuse AM. However, these changes were eradicated after FUAS. Meanwhile, the frequencies of these T cell subsets were positively correlated with the CA‐125 level. Furthermore, these T cell subsets were also increased in ectopic endometrium.ConclusionsOur study delineates for the first time the presence of CTLs, Tc17 cells, Th1, and ThGM cells in the blood and ectopic endometrium in AM. The results imply that T cell response might impact AM development.

show abstract

Spontaneous rupture of the uterus in the third trimester after high-intensity ultrasound ablation in adenomyosis: A case report

Cited by 5 publications

References 19 publications

Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

High Intensity Focused Ultrasound Ablation for Juvenile Cystic Adenomyosis: Two Case Reports and Literature Review

Cytotoxic T Lymphocytes, Tc17 Cells, Th1 Cells, and ThGM Cells are Increased in the Blood and Ectopic Endometrium of Patients With Adenomyosis

Contact Info

Product

Resources

About