Spontaneous rupture of the spleen in acute leukemia.Report of 2 cases

Hynes, Henry E.; Silverstein, Murray N.; Fawcett, Kenneth J.

doi:10.1002/1097-0142(196410)17:10<1356::aid-cncr2820171018>3.0.co;2-2

Cited by 54 publications

(16 citation statements)

References 6 publications

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“…Hynes and colleagues described three possible mechanisms of splenic rupture in patients with leukaemia: splenic infiltration due to haematological diseases, splenic infarction and coagulation disorders (which contributes to intracranial and subcapsular haemorrhages leading to an increased risk of rupture) 5. In this patient the combination of the CLL with oral anticoagulation led to the outcome.…”

Section: Discussionmentioning

confidence: 92%

Chronic lymphocytic leukaemia and spontaneous rupture of spleen

Nunes¹,

Pedroso

Carvalho

et al. 2018

BMJ Case Reports

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Pathological or spontaneous splenic rupture is a rare but well-recognised complication of haematological malignancies. The authors present a clinical report of a 78-year-old woman with known clinical history of chronic lymphocytic leukaemia and atrial fibrillation under anticoagulation with apixaban which has spontaneous splenic rupture. Pathological examination revealed lymph node and splenic infiltration due to chronic lymphocytic leukaemia. The diagnosis of splenic rupture must be considered in all patients with haematological malignancies who experience acute abdomen. Given the severity, it requires a correct and timely diagnosis.

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Section: Discussionmentioning

confidence: 92%

Chronic lymphocytic leukaemia and spontaneous rupture of spleen

Nunes¹,

Pedroso

Carvalho

et al. 2018

BMJ Case Reports

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“…In 1964, Hynes et al (11) proposed three possible mechanisms underlying spontaneous splenic rupture, which remain widely accepted to date: Mechanical effect of distention secondary to leukemic infiltration of the spleen, particularly the capsule; splenic infarct with capsular hemorrhage and subsequent rupture; and blood coagulation defects. However, it appears that none of the abovementioned mechanisms was responsible for the spontaneous splenic rupture in our patient.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report

Zhang¹,

Zhang²,

Chen³

et al. 2016

Molecular and Clinical Oncology

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Abstract. Spontaneous splenic rupture, also referred to as atraumatic splenic rupture, is a rare but life-threatening emergency condition. Without timely diagnosis and treatment, the mortality rate of splenic rupture approaches 100%. The etiology of atraumatic splenic rupture varies; it is reportedly associated with neoplasms or splenic infection, but is rarely encountered in patients with both conditions. We herein report the case of a 58-year-old male patient with acute myeloid leukemia (AML) complicated by splenic tuberculosis (TB), who presented with spontaneous rupture of the spleen. Pathological examination of the resected spleen revealed multifocal granulomatosis with caseous necrosis. However, with timely diagnosis and surgical intervention, the patient recovered successfully and is currently on consolidation therapy. To the best of our knowledge, this is the first case of spontaneous splenic rupture in AML with splenic TB. The relevant literature on spontaneous splenic rupture was also reviewed and the potential etiology and treatment were discussed.

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“…Small cysts are usually asymptomatic and are found incidentally by imaging techniques. Less often, there is splenomegaly and/or hepatomegaly, lymphadenopathy, abdominal distension, nausea, and vomiting [4][5][6][7][8][9][10][30][31][32][33]. These cysts do not require any further treatment unless the wall is very thin and in danger of rupture.…”

Section: Discussionmentioning

confidence: 99%