Spontaneous rupture of the spleen: A case report and review of the literature

Safapor, Faizollah; Aghajanzade, Menochehr; Kohsari, Mohammad Reza; Hoda, Saba; Safarpor, Damoun

doi:10.4103/1319-3767.33466

Cited by 6 publications

(4 citation statements)

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“…19 It has been proposed that splenic rupture does not relate to outcome, 5 but splenectomy in both emergent and elective cases is rarely curative. 2 Conversely, others have proposed that splenic rupture is the worst prognostic factor for survival, due to increased risk of peritoneal dissemination with direct implantation of neoplastic tissue associated with vascular access and hematogenous spread. 15 One rare clinical manifestation is gastrointestinal bleeding secondary to metastatic disease, and to our knowledge there have only been two previous reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…1 Although this pathological entity is rare, it is now regarded as the most frequent primary non-lymphoid malignant tumor of the spleen. 2,3 The literature is very limited concerning this specific sarcoma subtype, and due to its unique features and prognosis it is hard to standardize treatment strategies. Moreover, the morphologic spectrum of this disease is highly variable being similar in some aspects to vascular tumors such as hemangiomas, epithelioid hemangioendotheliomas and Kaposi's sarcoma, or malignant non-vascular tumors like lymphangiomas and secondary metastatic cancers, causing diagnostic difficulty.…”

Section: Introductionmentioning

confidence: 99%

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Systemic therapy in primary angiosarcoma of the spleen

et al. 2012

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Primary splenic angiosarcoma is a very rare neoplasm with a high propensity for metastatic disease and poor prognosis. There is a paucity of literature concerning this specific sarcoma subtype and the role of systemic therapy is not well defined. A retrospective review of the prospectively maintained University of Washington/Seattle Cancer Care Alliance Sarcoma Unit database was performed to identify patients with splenic angiosarcoma treated between 2007 and 2012. In total there were 19 patients with angiosarcoma treated at the Seattle Cancer Care Alliance from 2007 to 2012. The number of patients with splenic angiosarcoma was 2 (11%). The first patient was a woman aged 57 years who was referred with metastatic splenic angiosarcoma to the liver, post-splenectomy. She was treated with 4 cycles of weekly paclitaxel prior to metastatic resection and 4 cycles of the same drug in an adjuvant scenario, achieving a pathological complete response to treatment. She is alive and on third-line systemic therapy. The second patient was a male patient aged 30 years who presented with metastatic high-grade splenic angiosarcoma and was treated with 3 lines of systemic therapy, including doxorubicin, paclitaxel and gemcitabine+docetaxel, but developed a gastrointestinal metastasis with subsequent gastrointestinal bleeding. Splenic angiosarcoma is a very rare neoplasm. Surgery remains the mainstay of management for localized disease. Paclitaxel administered weekly proved to be well-tolerated and resulted in a good radiological response in one of our patients, enabling resection of metastatic disease. Durable clinical benefit can be achieved in metastatic splenic angiosarcoma with multi modality management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic therapy in primary angiosarcoma of the spleen

et al. 2012

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“…Dans 8% des cas, les malades décèdent avant d'être opérés et le diagnostic n'est fait qu'à l'autopsie. Dans 85% des cas, les malades sont traités par splénectomie [4]. Chez 7% des malades (surtout dans le cadre d'une MNI) un traitement médical conservateur sans chirurgie a été tenté [5-7].…”

Section: Discussionunclassified

Rupture spontanée de la rate chez un enfant

Alaoui¹,

Raiss²,

Khatalla³

et al. 2019

Pan Afr Med J

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Les ruptures non traumatiques ou spontanées de la rate (RNTR) sont des entités rares mais potentiellement mortelles. La mortalité de cette affection est essentiellement liée au retard diagnostique et thérapeutique, ainsi qu'aux risques liés au terrain et à la gravité de la pathologie sous-jacente. Elles nécessitent dans la majorité des cas une splénectomie. Elles peuvent survenir soit sur une rate macroscopiquement saine, par exemple au cours d'une mononucléose infectieuse (MNI) ou d'un accès palustre ou sur une rate pathologique par exemple tumorale mai aussi dans certaines coagulopathies. Dans notre cas il s'agit d'un enfant de 6 ans suivi pour une coagulopathie admis pour douleurs abdominales diffuses brutales, une pâleur cutanéo-muqueuse avec un état hémodynamique stable. Le bilan biologique a révèle une anémie normochrome macrocytaire; le diagnostic de confirmation de la rupture était réalisé par l'échographie et le scanner abdominal. Vu la stabilité de l'état hémodynamique, la décision d'un traitement conservateur a été prise avec transfusions de 2 culots globulaires. L'évolution était favorable.

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“…In 8% of the cases, the patients die before being operated and the diagnosis is only made at autopsy. In 85% of cases, patients are treated by splenectomy [16]. In 7% of patients (mostly in the context of Infectious mononucleosis) conservative medical treatment without surgery was attempted [9][10][11][12][13][14][15][16][17][18].…”

Section: Patient Et Observationmentioning

confidence: 99%

Spontaneous rupture of the spleen

OMAR

2023

AJMCRR

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Introduction : Non-traumatic ruptures can be fatal, the diagnosis is sometimes difficult. They often reveal an underlying pathology, notably infectious, tumoral or hematological. The clinical presentation is usually acute, but progressive forms are possible. The majority of patients are splenectomized. Materials and Methods:We report a case Spontaneous rupture of the spleen in the department of Emergency visceral surgery.Results: Our patient was admitted to the emergency room with diffuse abdominal pain of sudden onset with onset of epigastric pain and incoercible vomiting rupture five days before days the consultation with clinical examination: conscious patient stable on the hemodynamic and respiratory plan The examination noted generalized abdominal defense the hernial orifices were free, apyrexial, and sensitization of the left hypochondrium. The laboratory investigations was normal. X-ray of the abdomen without preparation (ASP) was without particularities.The abdominal CT scan showed a medium-sized hemoperitoneum on probable splenic the patient were operated in the emergency room, approached by laparotomy with the exploration we found a mediumsized hemoperitoneum on probable splenic rupture ,A splenectomy was performed. Conclusion:Spontaneous rupture of the spleen is a rare entity whose diagnosis is difficult in the absence of a traumatic context. It can be life threatening. Ultrasound and CT scans help to orient the diagnosis.The overall mortality is about 20% and seems to be mainly related to the delay in diagnosis and/or the severity of the underlying pathology. Infectious etiologies, dominated by Infectious mononucleosis, and

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Spontaneous rupture of the spleen: A case report and review of the literature

Cited by 6 publications

References 0 publications

Systemic therapy in primary angiosarcoma of the spleen

Systemic therapy in primary angiosarcoma of the spleen

Rupture spontanée de la rate chez un enfant

Spontaneous rupture of the spleen

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