Spontaneous resolution of syringomyelia following pregnancy and parturition in a patient with type I chiari malformation: A case and systematic review

Kilgore, Mitchell D.; Mathkour, Mansour; Dunn, Rachel; Scullen, Tyler; Gouveia, Edna E.; Shapiro, Stephen Z.; Glynn, Ryan; Tubbs, R. Shane; Bui, Cuong J.

doi:10.1016/j.clineuro.2022.107413

Cited by 1 publication

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aetiologies for syrinx formation include pathologies with increased intracranial pressure (ICP) (such as hydrocephalus, space-occupying lesions, head injury, and veno-occlusive disease), CM1, trauma, multiple sclerosis, spinal tumours and idiopathic aetiology [ 1 ]. However, there are very few reported endocrine cases of syrinx formation [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ]. Since then, several cases (with a mixture of pediatric and adult populations) have been reported in the literature, with the majority being associated with CM1 [ 2 , 3 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first report of an MRI-verified spontaneous resolution of syringomyelia was in 1990 by Sudo et al [9]. Since then, several cases (with a mixture of pediatric and adult populations) have been reported in the literature, with the majority being associated with CM1 [2,3,8].…”

Section: Aetiology Of Syrinx Formation and Resolutionmentioning

confidence: 99%

See 2 more Smart Citations

Resolution of Large Cervico-Thoracic Syringomyelia Following Treatment of Thyrotoxicosis: A Case Report

Craven¹,

Mullins²,

Pradini-Santos³

et al. 2023

Cureus

View full text Add to dashboard Cite

Treatment for a large symptomatic syrinx associated with a Chiari 1 is predominately surgical, via a foramen magnum decompression (FMD), with the aim to normalise cerebrospinal fluid (CSF) movement. Whilst theories of underlying hyperdynamic states in Chiari 1 and Syringomyelia exist, to date there is no effective medical treatment to reverse Syringomyelia. A 17-year-old female was referred with a seven-month history of gradually progressive impaired temperature sensation in her left upper limb. She had also been concomitantly diagnosed with thyrotoxicosis. Magnetic resonance imaging (MRI) confirmed a Chiari 1 with a large syrinx. The patient preferred to avoid surgery in the first instance. She underwent treatment for her thyrotoxicosis. The eight-month, 20- and 36-month follow-up MRI scans demonstrated a gradual resolution of the Chiari 1 malformation and the syrinx. Whilst there have been reports of Chiari 1 malformation association with hyperthyroidism, this is the first report describing syrinx resolution following treatment of thyrotoxicosis. Hyperdynamic circulation can result in syrinx formation through various mechanisms. We hypothesise that the treatment of thyrotoxicosis resulted in normalisation of CSF pulse amplitude and subsequent syrinx resolution. Hyperthyroidism evaluation may be explored in studies of CM1 and Syrinx or other CSF disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[ 9 ]. Since then, several cases (with a mixture of pediatric and adult populations) have been reported in the literature, with the majority being associated with CM1 [ 2 , 3 , 8 ].…”

Section: Discussionmentioning

confidence: 99%