Introduction: Prevalence of GSD has been 10-20% in developed countries, 2.5-10% in African populations, and 3.1-6.1% in Asians. Approximately 3-8% of GSD patients experience complications, including cholecystitis, gallstone ileus, pancreatitis, empyema, and gallbladder perforation. Therefore, GSD care could be expensive and place a considerable burden on the budget of health systems.Case report: A 57-year-old female admitted to the emergency room due to oral intolerance and abdominal pain. In the ER, she presented abdominal distension, inability to pass bowel motions or gas, with the requirement of nasogastric tube placement, and discharge with intestinal characteristics was obtained, upon admission leukocytosis of 20,000 with neutrophilia. CT scan showed a stone of probable biliary origin impacted in the terminal ileum, pneumobilia, and uncomplicated diverticular disease. She was evaluated by general surgery, performing exploratory laparotomy with the following findings: Impacted gallstone at 20 cm from the ileocecal valve, distended small bowel loops, no evidence of ischemia, and scant peritoneal reaction fluid. Enterolithotomy was performed 30 cm from the ileocecal valve plus primary closure with Heineke-Mikulicz technique.Discussion: Gallstone ileus is a mechanical small bowel obstruction induced by an impacted ectopic gallstone. The terminal ileum and ileocecal valve are the most common sites of gallstone impaction. Generally, gallstones < 2-2.5 cm have a high probability of spontaneous transit. Gallstone ileus is a rare long-term complication of cholelithiasis. Risk factors include female gender, age > 65 years, history of episodes of untreated cholecystitis, and larger stones (> 2.5 cm).