Spontaneous Renal Disease in Laboratory Animals

Burek, J. D.; Duprat, Pierre; Owen, Roger A.; Peter, C. P.; Zwieten, Matthew J. van

doi:10.1016/b978-0-12-364930-0.50009-9

Cited by 17 publications

(9 citation statements)

References 126 publications

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“…This renal disease, which is a common feature in the aging rat, affects preferentially the male and has a higher incidence and severity for some strains such as the Sprague-Dawley (30)(31)(32)(33)(34)(35)(36).…”

Section: Long-term Conseguences Of the Nephrons' Adaptation To Their mentioning

confidence: 99%

Long-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat

1991

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ABSTRACT. Renal clearance studies and morphologic observations were performed in rats aged 14, 21, and 28 d and 3, 6, 9, and 12 mo born with a 20% reduction in nephron number after administration of 75 mg/kg/d of gentamicin to their mothers during the second half of gestation. Gentamicin was still present in urine 3 mo after birth. Morphologic damage characteristic of gentamicin accumulation was observed in the kidney on d 14 and 21. Adequate compensatory adaptation to oligonephronia occurred for glomerular function within 14 d of birth, but tubular phosphate reabsorption was significantly low on d 21. On d 28, no evidence of histologic or functional damage to the kidney was observed. At 3 mo, mesangial lesions were observed in rats of the gentamicin group, whereas they were rarely present in 6-mo-old control rats. Furthermore, glomerular sclerotic lesions were already evident in about 5% of the juxtamedullary nephrons. The same percentage of injured nephrons was not observed before 12 mo in controls. Complementary morphologic data obtained in 24-mo-old rats showed that glomerulosclerosis involved 40% of the juxtamedullary nephron population at this age in animals of the gentamicin group versus 21% in controls.

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Section: Long-term Conseguences Of the Nephrons' Adaptation To Their mentioning

confidence: 99%

Long-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat

1991

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“…The most common renal disease in rats is chronic progressive nephropathy or old rat nephropathy. [73][74][75] The incidence can be up to 75% in affected strains. This disease affects older animals and is more common and severe in males, with a much higher incidence in S-D and Fischer 344 rats.…”

Section: Degenerative/congenitalmentioning

confidence: 99%

Disease Overview of the Urinary Tract in Exotic Companion Mammals and Tips on Clinical Management

Reavill

Lennox

2020

Veterinary Clinics of North America: Exotic Animal Practice

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There are some species-specific disease conditions and anatomic structures of the urinary tract, including the composition of uroliths, an open inguinal ring in male rabbits and rodents, a cloaca in sugar gliders, and the presence of a baculum. Hematuria is a common clinical sign for various urinary tract diseases. Therapy for most urinary tract diseases is based on procedures common to domestic species (dogs and cats).

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“…Information about naturally occurring KD in pet rabbits is scarce. Nevertheless, different reports have suggested that rabbit kidneys can be affected by many disorders, although most of these studies refer to kidney conditions in laboratory rabbits 1,3,5-8 . Since diseases affecting pet or laboratory rabbits may be different, there is an urgent need to increase our knowledge in pet rabbit KD that will improve its management.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of urine dipstick for proteinuria assessment in pet rabbits

Gallego

Porquet

2021

Veterinary Record

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Background: Naturally occurring kidney disease (KD) in pet rabbits has not been fully characterized. It has been previously suggested that proteinuria, especially when associated with isosthenuria, may be an early indicator of KD prior to azotaemia in rabbits. The aim of the current study was to assess the diagnostic utility of the urinary protein dipstick test (UPDT) for detecting proteinuria in rabbit urine samples as a useful diagnostic tool in clinical setting. Methods: Three hundred urinalyses from 156 pet rabbits were retrospectively analysed by comparing the UPDT with the urine protein:creatinine ratio (UPC) to assess its diagnostic performance in detecting proteinuria, defined as UPC > 0.3. Sensitivity, specificity, positive and negative predictive values (NPVs) were determined. Results: When urine‐specific gravity (USG) was ≤1.024 and a UPDT result of >0 was considered proteinuric, the specificity and positive predictive value (PPV) were both 100%. Following the same criteria, specificity and PPV decreased to 92.1% and 92.5% when USG was ≤1.038. NPVs were poor. Conclusion: In rabbits, a UPDT result > 0 is indicative of proteinuria (UPC > 0.3) when the USG is ≤1.024. In all other cases, proteinuria should be measured using the UPC.

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Spontaneous Renal Disease in Laboratory Animals

Cited by 17 publications

References 126 publications

Long-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat

Long-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat

Disease Overview of the Urinary Tract in Exotic Companion Mammals and Tips on Clinical Management

Evaluation of urine dipstick for proteinuria assessment in pet rabbits

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