Spontaneous Renal Artery Aneurysm Rupture in a Patient With Neurofibromatosis Type 1 Without Risk Factors for Renal Artery Aneurysm Rupture

Niwa, Naoya; Yanaihara, Hitoshi; Horinaga, Minoru; Nakahira, Yoko; Hanashima, Fuminari; Asakura, Hirotaka

doi:10.1177/1538574413495465

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…[ 6 ] Renal artery aneurysms may be unilateral or bilateral with or without calcification, and rupture may occur spontaneously without risk factors in NF-1 patients. [ 11 – 13 ] Endovascular treatment for NF-1 related renal artery aneurysms is rarely reported. Triantafyllidi et al [ 14 ] described the 1st percutaneous transluminal renal angioplasty to restore renal artery anatomy and treat hypertension in an adult female patient.…”

Section: Discussionmentioning

confidence: 99%

Endovascular management of renal artery aneurysms induced by neurofibromatosis type 1

Zhang

Zou²,

Yang³

et al. 2017

Medicine

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Rationale:Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by cafe au lait macules and neurofibromatosis. Renal artery aneurysms are relatively uncommon. Endovascular techniques are effective in treating renal aneurysms but successful cases are rarely reported in NF-1 adults.Patient concerns:The patient was one 23-year-old female presented with hypertension, multiple café-au-lait spots ≥15 mm, and plexiform neurofibroma. Renal artery aneurysms were found by ultrasound.Diagnoses:NF-1 was diagnosed based on clinical manifestations and confirmed by gene test. Renal artery aneurysms were diagnosed based on computed tomography.Interventions:Bilateral renal artery angiography was performed and 3 aneurysms were found sequentially on the left anterior superior segmental artery. Microcoil embolization of aneurysms was undertaken.Outcomes:The patient's blood pressure decreased after the procedure with reduction of medicine. A 3-month follow-up unilateral selective renal angiogram demonstrated little change in size of aneurysms, and no opacification of the aneurysmal sac was found. Serum creatinine remained in normal range at 3-month.Lessons:Successful endovascular treatment for NF-1 related renal artery aneurysms in adults is reported for the 1st time with preserved renal function and improved hypertension. Endovascular procedure is considered to be feasible and effective for renal artery aneurysms induced by NF-1.

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Section: Discussionmentioning

confidence: 99%

Endovascular management of renal artery aneurysms induced by neurofibromatosis type 1

Zhang

Zou²,

Yang³

et al. 2017

Medicine

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“…She was successfully treated with selective embolization. There have been 3 case reports involving spontaneous artery aneurysm rupture in a patient with NF1 6 ; however, to our knowledge, this is the only case describing the treatment of accessory renal artery aneurysm rupture.…”

Section: Introductionmentioning

confidence: 91%

Spontaneous Accessory Renal Artery Aneurysm Rupture in a Patient With Neurofibromatosis Type 1: A Case Report

Roberts

Fan

Brightwell

2018

Vasc Endovascular Surg

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True renal artery aneurysms are rare. Ruptured aneurysms are even rarer but can have devastating consequences. Renal artery aneurysms most commonly occur in patients with hypertension, atherosclerosis, or fibromuscular dysplasia. Treatment options can range from embolization to nephrectomy. We describe an interesting case of spontaneous accessory renal artery aneurysm rupture in a 44-year-old female with neurofibromatosis type 1 (NF1) who otherwise had no medical problems. She was successfully treated with selective coil embolization, recovered without complications, and maintained preoperative renal function.

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Fatal acute retropharyngeal hemorrhage in neurofibromatosis type 1

Peyron

Pollanen

2017

Forensic Sci Med Pathol

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We report the sudden death of a woman with neurofibromatosis type 1 (NF1). The decedent developed acute respiratory distress and died rapidly despite an emergent cricothyroidotomy. An autopsy with postmortem CT scan was performed to determine the cause of the fatal respiratory collapse and to determine if death was related to neurofibromatosis. Postmortem examination revealed the classical external hallmarks of neurofibromatosis, including innumerable cutaneous neurofibromas. In addition, there was a massive retropharyngeal hematoma with fatal extrinsic compression of the airway. On macroscopic examination A localized 3 cm diameter tumor nodule was found in the soft tissues of the neck. Histologic examination of the nodule revealed a neurofibroma. In addition, histologic sections of the hematoma and surrounding soft tissues revealed plexiform neurofibroma with infiltration of the walls of small blood vessels and of the right vertebral artery. The fatal retropharyngeal hemorrhage was caused by diffuse infiltration of the blood vessels of the neck by plexiform neurofibroma. We concluded that the underlying cause of death was NF1. This case underscores the protean nature of neurofibroma, particularly when diffuse interstitial hemorrhage is present. Infiltration of soft tissues by neurofibroma may only be detectable on histologic examination.

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Spontaneous Renal Artery Aneurysm Rupture in a Patient With Neurofibromatosis Type 1 Without Risk Factors for Renal Artery Aneurysm Rupture

Cited by 8 publications

References 9 publications

Endovascular management of renal artery aneurysms induced by neurofibromatosis type 1

Endovascular management of renal artery aneurysms induced by neurofibromatosis type 1

Spontaneous Accessory Renal Artery Aneurysm Rupture in a Patient With Neurofibromatosis Type 1: A Case Report

Fatal acute retropharyngeal hemorrhage in neurofibromatosis type 1

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