Spontaneous remission of a squamous cell carcinoma of the floor of the mouth

Sousa, Alexandre de Andrade; Rena, Rafael Lopes; Silva, Guilherme Souza; Soares, João Marcos Arantes; Porcaro-Salles, José Maria; Nunes, Laiz Fernandes Mendes; Mesquita, Ricardo Alves; Jham, Bruno Correia

doi:10.1016/j.jcms.2014.04.026

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…The first reported case was a patient with SCCa of the left tonsil and base of tongue in 1910, and there are recent reports of floor of mouth and tongue SCCa resolutions. 7,8,11 To our knowledge, spontaneous cervical lymph node metastasis resolution has only been reported once in the head and neck literature; in that report, the size of the metastatic oropharyngeal SCCa deposit decreased radiographically over the course of weeks after the FNA biopsy, and histologic examination of the subsequently resected lymph node showed residual SCCa with evidence of apoptosis. 9 In contrast, our current case showed complete histologic tumor regression, with morphologic features similar to those seen in tumor regression after neoadjuvant chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 93%

“…6 Spontaneous regression of a primary SCCa in the oral cavity has been reported; however, there have been no reports to our knowledge that identified regression of locoregionally advanced cutaneous SCCa. 7,8 We present a patient with history of prior cutaneous SCCa resection with regional lymph node spread which regressed without any medical treatment over a period of 5 months in the setting of a dental infection and fine needle aspiration (FNA).…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous regression of squamous cell carcinoma in the setting of dental infection and needle biopsy

Divakar

Khan

Polacco

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Spontaneous regression of squamous cell carcinoma in the setting of dental infection and needle biopsy

Divakar

Khan

Polacco

et al. 2020

Clinical Case Reports

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“…Tumor regression can infrequently occur for other tumor types that are known to be very immune sensitive, such as cutaneous Merkel cell carcinoma and melanoma, and there are actually hundreds of case reports of regressed cancers, including some squamous cell carcinomas (106,107). However, the experience in patients with clinically evident squamous cell carcinoma would indicate that once there is a measurable primary cancer, it is extremely rare for this to regress.…”

Section: Undiscovered Primaries Remaining After Extensive Endoscopiesmentioning

confidence: 99%

Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer: Management in the HPV Era

et al. 2020

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“…1D). Moreover, several studies have demonstrated that cell and microenvironmental signaling can lead to spontaneous regression in several types of primary and metastatic cancers [26][27][28][29][30] (Fig. 1E).…”

Section: Overview Of the Metastatic Processmentioning

confidence: 99%

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

2016

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More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic diseases. Recent studies have highlighted the importance of the multicellular, biochemical and biophysical stimuli from the tumor microenvironment during carcinogenesis, treatment failure, and metastasis. Therefore, there is a need for experimental platforms that are able to recapitulate the complex pathophysiological features of the metastatic microenvironment. Recent advancements in biomaterials, microfluidics, and tissue engineering have led to the development of living multicellular microculture systems, which are maintained in controllable microenvironments and function with organ level complexity. The applications of these "on-chip" technologies for detection, separation, characterization and three dimensional (3D) propagation of cancer cells have been extensively reviewed in previous works. In this contribution, we focus on integrative microengineered platforms that allow the study of multiple aspects of the metastatic microenvironment, including the physicochemical cues from the tumor associated stroma, the heterocellular interactions that drive trans-endothelial migration and angiogenesis, the environmental stresses that metastatic cancer cells encounter during migration, and the physicochemical gradients that direct cell motility and invasion. We discuss the application of these systems as in vitro assays to elucidate fundamental mechanisms of cancer metastasis, as well as their use as human relevant platforms for drug screening in biomimetic microenvironments. We then conclude with our commentaries on current progress and future perspectives of microengineered systems for fundamental and translational cancer research.

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Spontaneous remission of a squamous cell carcinoma of the floor of the mouth

Cited by 10 publications

References 29 publications

Spontaneous regression of squamous cell carcinoma in the setting of dental infection and needle biopsy

Spontaneous regression of squamous cell carcinoma in the setting of dental infection and needle biopsy

Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer: Management in the HPV Era

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

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