Spontaneous remission in acute myeloid leukaemia

Paul, R.; Remes, Kari; Lakkala, Taina; Tt, Pelliniemi

doi:10.1111/j.1365-2141.1994.tb03281.x

Cited by 47 publications

(31 citation statements)

References 5 publications

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“…Additionally, as tumor accumulates antigens during transformation they also gradually induce tolerance in T cells against these antigens. Notwithstanding these and other escape mechanisms, in few cancer patients a spontaneous regression of malignant tumors was observed (23,24). Data about potential coupling of auto-antibodies and prolonged/sustained survival or even spontaneous tumor regression corroborate the previous observation.…”

Section: Anti-tumor Immunity As Auto-immunity 7xprughyhorsphqwlviuhtxsupporting

confidence: 81%

Auto-immunity as Evolutionary by Product of Adoptive Immunity and Source of Anti-tumor Immunity Failure

Bubanovic¹

2005

International J. of Cancer Research

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One of the biggest threats to survival is infection, so that the immune system is under permanent and strong evolutionary pressure to be highly responsive. By tracing the evolution of the invertebrate LPPXQH V\VWHP LW FDQ EH VHHQ WKDW LW ODUJHO\ IROORZHG WKH ³FODVVLFDO´ PRGHO EDVHG RQ EL-directional Evolution of the Vertebrate Immune SystemSome evolutionary processes can be studied directly, while the evolution of the immune system and immunity cannot. The evolution of immunity is a macro-evolutionary process, which can be studied by examining the patterns in biological populations or species of related organisms and inferring process from pattern. One of the possible ways to carry out a detailed investigation into the issue of the evolution of the immune system is virtually by comparing the characteristics of the immune system across species and classes. In addition, the determination of the genes and molecules conserved throughout evolution is helpful in identifying the mechanisms of the immune system evolution, while variable genes as well as the emergence of new genes along evolution enable the identification of various evolutionary pressures, their duration and strength. This provides a better understanding of how the immune system works under physiological and pathological conditions. This approach, however, is not an easy one since only few percent of the total number of species that have inhabited the planet to date are available for research. Notwithstanding this limiting factor, previous studies have produced sufficient findings for the construction of a hypothetical model of the evolution of the immune system in vertebrates, and also cleared the pathway towards reaching further relevant presumptions and conclusions.

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Section: Anti-tumor Immunity As Auto-immunity 7xprughyhorsphqwlviuhtxsupporting

confidence: 81%

Auto-immunity as Evolutionary by Product of Adoptive Immunity and Source of Anti-tumor Immunity Failure

Bubanovic¹

2005

International J. of Cancer Research

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“…Infections and transfusions have been claimed to favour SR in AML patients [4,9,13]. We observed a SR in an AML patient occurring in the course of a severe invasive hyalohyphomycotic infection (invasive aspergillosis) and after several platelet and red blood cell transfusions.…”

Section: Discussionmentioning

confidence: 73%

Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis

Tzankov¹,

Ludescher

Duba

et al. 2001

Ann Hematol

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Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed.

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“…A diagnosis of RAEB in T was made after the improvement of the infection. This finding is inconsistent with spontaneous regression of acute leukaemia, which is observed after severe infection [4]. Almost all the patients with AML or MDS, who have been reported to achieve CR by G-CSF, had infections when G-CSF therapy was given [1, 2, 5, 6, 7].…”

Section: Discussionmentioning

confidence: 99%

Remission Induction of Refractory Anaemia with Excess Blasts in Transformation by Sole Treatment with Granulocyte Colony-Stimulating Factor with Persistent Chromosomal Abnormality

Kondo¹,

Kasahara²,

Mori³

2002

Acta Haematol

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We report a patient with myelodysplastic syndrome (MDS), refractory anaemia with excess blasts in transformation, in whom complete remission (CR) was achieved with the administration of granulocyte colony-stimulating factor (G-CSF). The 76-year-old patient was admitted to our hospital with a fever and a productive cough; a diagnosis of pneumonia was thus made. Following treatment with antibiotics, the patient’s condition improved, and MDS was diagnosed from peripheral blood and bone marrow examinations after the patient recovered from the infection. The patient achieved a sustained haematological CR that was confirmed by morphological and flow cytometric examination after treatment with G-CSF alone, although chromosomal abnormalities persisted. According to the literature, in almost all patients with acute myeloid leukaemia or MDS who were reported to achieve CR by G-CSF, the course was associated with infection, although our case did not have this complication during the course of G-CSF therapy. We suggest that patients with G-CSF alone without infection can achieve CR and that this may be related to a differentiation effect of G-CSF based on persistent chromosomal abnormality in this case.

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Spontaneous remission in acute myeloid leukaemia

Cited by 47 publications

References 5 publications

Auto-immunity as Evolutionary by Product of Adoptive Immunity and Source of Anti-tumor Immunity Failure

Auto-immunity as Evolutionary by Product of Adoptive Immunity and Source of Anti-tumor Immunity Failure

Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis

Remission Induction of Refractory Anaemia with Excess Blasts in Transformation by Sole Treatment with Granulocyte Colony-Stimulating Factor with Persistent Chromosomal Abnormality

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