Spontaneous regression of pulmonary metastases following palliative nephrectomy.Case report

Markewitz, Moshe; Taylor, D.A.; Veenema, Ralph J.

doi:10.1002/1097-0142(196707)20:7<1147::aid-cncr2820200718>3.0.co;2-k

Cited by 32 publications

(4 citation statements)

References 21 publications

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“…Nephrectomy seldom results in regression of pulmonary metastases. Fewer than 50 examples have been reported (2)(3)(4)(5)(6)(7)(8). The true incidence of regression of hypernephroma is unknown.…”

Section: Discussionmentioning

confidence: 99%

Regression of Metastatic Hypernephroma

Dubrow

1977

J American Geriatrics Society

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A 71-year-old woman had massive pulmonary metastases from a right hypernephroma, as shown by a chest roentgenogram. Nine days after nephrectomy, there was no roentgenographic evidence of such metastases. This represents the most rapid regression of clear-cell pulmonary metastases ever reported. Metastases reappeared six months postoperatively and the patient died of widespread metastatic disease 18 months after nephrectomy. The unpredictable behavior of metastatic hypernephroma is discussed.

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Section: Discussionmentioning

confidence: 99%

Regression of Metastatic Hypernephroma

Dubrow

1977

J American Geriatrics Society

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“…Twelve (29%) survived 5 years, although 3 died of renal carcinoma after 5 years. 59 Markewitz et al 34 performed palliative nephrectomy in 29 patients, only 1 of whom showed regression of lung lesions with dramatic improvement of clinical state lasting 1 year. At autopsy many of the metastases showed necrosis and lymphocytic infiltration suggesting an immune response.…”

Section: Role Of Palliative Nephrectomymentioning

confidence: 99%

Cancer of the kidney—natural history and staging

Holland

1973

Cancer

151

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The natural history of renal cell carcinoma is kaleidoscopic. Growth may be indolent, intermittent, or rapid. The tumor may remain encapsulated for years. Ultimately it may invade intrarenal veins and lymphatics, thence to vena cava, aortic nodes, thoracic duct, and beyond. Spread to contiguous organs gives entry to portal and vertebral venous systems. Unusual metastases are common. Gross hematuria, loin pain, and mass occur together in only 10‐15% and portend advanced neoplasm. Microscopic hematuria is found in about two‐thirds. Non‐specific signs and symptoms such as fatigue, weight loss, gastrointestinal symptoms, fever, and anemia are misleading. Fascinating clues such as hypercalcemia, erythrocytosis, hepatopathy, polyneuritis, acute left varicocele, etc., may alert the wary clinician. Rare but titillating spontaneous regression of hypernephroma metastases, usually pulmonary and in older males, have occurred whether or not nephrectomy is done. About 60 cases have been reported. Understanding this apparent tumor‐specific immunologic response may bring earlier diagnosis and control of metastases. Selection of best treatment requires surveying metastatic sites. Accurate staging at operation and at the time of recurrence is imperative to help determine cause and correction of treatment failures.

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“…A surgical exploration with a palliative right nephrectomy was performed on December 16,1970. A renal tumor which was superficially invading the right lobe of the liver was dissected from the liver and diaphragm.…”

Section: Case Reportsmentioning

confidence: 99%

Regression of metastatic renal cell carcinoma following nephrectomy

Garfield

Kennedy

1972

Cancer

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Regression of pulmonary metastases following nephrectomy for renal cell carcinoma has occurred in two patients. In one patient, a hepatopathy also disappeared, and the patient remained free from disease for 16 years. In the other patient, following nephrectomy there was disappearance of hypercalcemia, presumably due to removal of a source of production of a parahormone‐like polypeptide. It appears that older males with only pulmonary metastases make up the majority of patients in whom regression of metastases after nephrectomy has been observed. Hormonal and immunologic factors are implicated in this phenomenon. There is a sound rationale for nephrectomy in the presence of metastatic renal cell carcinoma.

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Spontaneous regression of pulmonary metastases following palliative nephrectomy.Case report

Cited by 32 publications

References 21 publications

Regression of Metastatic Hypernephroma

Regression of Metastatic Hypernephroma

Cancer of the kidney—natural history and staging

Regression of metastatic renal cell carcinoma following nephrectomy

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