Spontaneous regression of metastatic cancer cells in the lymph node: a case report

Choi, Nayeon; Cho, Jae Keun; Baek, Chung‐Hwan; Ko, Young‐Hyeh; Jeong, Han‐Sin

doi:10.1186/1756-0500-7-293

Cited by 7 publications

(3 citation statements)

References 17 publications

(16 reference statements)

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“…We could not confirm the disappearance of metastatic lymph node after EUS-FNA. The patient died because of the progression of the primary gastric cancer; however, we considered that the metastatic lymph node might have become undetectable after EUS-FNA due to “spontaneous regression.” To date, according to a key word survey of the PubMed database, several studies have reported disappearance of metastatic lymph nodes in cancer patients after FNA or biopsy procedures ( 6 , 7 ). In addition, the infiltration of inflammatory cells was found at the site of tumor regression.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the infiltration of inflammatory cells was found at the site of tumor regression. Some reports have described the accumulation of T cells and natural killer (NK) cells in the histological specimens of regressed tumors ( 7 , 8 ). Taking into account the above points, we considered that the immunological responses might have promoted the disappearance of the metastatic lymph node in our case.…”

Section: Discussionmentioning

confidence: 99%

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The Disappearance of Lymph Node Metastasis from Neuroendocrine Carcinoma after Endoscopic Ultrasound-guided Fine Needle Aspiration

et al. 2016

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A 75-year-old Japanese man was referred to our hospital to undergo the examination of an enlarged peripancreatic lymph node. Computed tomography (CT) showed a lymph node 47 mm in size that was located above the pancreas head and beneath the liver. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of the enlarged lymph node was performed, and an immunohistological examination of the sample confirmed a histological diagnosis of neuroendocrine carcinoma (NEC). The patient refused treatment with chemotherapy and instead chose to undergo observation. However, the lymph node the previously enlarged lymph node was not visible on CT at 12 months after the examination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Disappearance of Lymph Node Metastasis from Neuroendocrine Carcinoma after Endoscopic Ultrasound-guided Fine Needle Aspiration

et al. 2016

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“…Спонтанную регрессию связывают с эффекторными клетками противоопухолевого иммунитета, которые, по недостаточно изученным на данный момент причинам, только в очень редких случаях могут привести к полной регрессии злокачественного образования. Данный про-цесс обусловлен инфильтрацией опухоли иммунокомпе-тентными клетками, что подтверждается клиническими исследованиями, обнаружившими выраженную лимфо-идную инфильтрацию у больных со спонтанной регресси-ей меланомы [9,10,11].…”

Section: спонтанная регрессия меланомыunclassified

Lymphoid infiltration as a predictor of successful immunotherapy with melanoma

Titov¹,

Chikileva²,

Киселевский³

et al. 2017

Zlokač. opuholi

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Лимфоидная инфильтрация как предиктор эффективности иммунотерапии меланомыLymphoid infiltration as a predictor of successful immunotherapy with melanoma www.malignanttumours.org • № 1 -2017 г. (22) • MALIGNANT TUMOURS РезюмеМеланома кожи составляет 1-4% от всех онкологических заболеваний. Среди всех злокачественных опухолей кожи меланома занимает особое место, на ее долю приходится около 4% от всех форм онкологических заболеваний кожи, однако 80% смертей в данной группе обусловлено именно меланомой. В 2014 году в России стандартизованный показатель смертности от меланомы кожи составил 1,51 на 100 000 населения. Заболеваемость меланомой кожи в РФ и многих странах мира неуклонно растет. По абсолютному приросту заболеваемости среди всех злокачественных опухолей меланома кожи занимает 2 место после рака легкого. Увеличение числа случаев заболеваемости меланомой диктует необходимость углубленного изучения биологии данной опухоли и ее взаимодействия с системой иммунобиологического надзора. Учитывая иммуногенность меланомы, важное значение имеет характер и степень иммунного ответа на опухоль. Поэтому одним из важных прогностических факторов течения меланомы является степень выраженности и субпопуляционный состав лимфоидной инфильтрации опухоли, которая также имеет значение для подбора индивидуализированного лечения современными иммунотерапевтическими препаратами, в частности ипилимумабом, биомишенью для которого является супрессорный рецептор Т-лимфоцитов CTLA-4. AbstractCutaneous melanoma is 1-4% of all cancers. Among all malignant skin tumors, melanoma has a special place, it accounts for about 4% of all forms of skin cancer, but 80% of deaths in the group of malignant tumors of the skin caused by melanoma. In 2014 in Russian Federation, the standardized death rate from melanoma of the skin was 1.51 per 100 000 population. The incidence of melanoma has been steadily growing in Russian Federation and many other countries. In absolute increase the incidence of all malignant tumors, skin melanoma is ranked 2nd after lung cancer. Increased incidence of melanoma necessitates in-depth study of the biology of this tumor and its interaction with the immunobiological control system. Considering the immunogenicity of melanoma, the importance of the nature of the immune response to growing tumor. Therefore, one of the most important prognostic factor of the disease in these patients is the severity and subpopulations of lymphoid infiltration of the tumor, which is also important for the selection of personalized treatments with modern immunotherapeutic drugs, such as ipilimumab, which is the biological target for T cell suppressor receptor CTLA-4.

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Kappauf¹

2021

Springer Reference Medizin

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Spontaneous regression of metastatic cancer cells in the lymph node: a case report

Cited by 7 publications

References 17 publications

The Disappearance of Lymph Node Metastasis from Neuroendocrine Carcinoma after Endoscopic Ultrasound-guided Fine Needle Aspiration

The Disappearance of Lymph Node Metastasis from Neuroendocrine Carcinoma after Endoscopic Ultrasound-guided Fine Needle Aspiration

Lymphoid infiltration as a predictor of successful immunotherapy with melanoma

Spontanremissionen

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