Spontaneous regression of malignant tumors

Dobson, Leonard; Dickey, Lloyd B.

doi:10.1016/s0002-9610(56)80056-1

Cited by 21 publications

(4 citation statements)

References 17 publications

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“…The clinical characteristics of the three previously reported cases are summarized and compared to our patient in table 1. (11–13) The pathological definition of IFS remains debatable, and diagnosis should not be based solely on either the patient’s age or the tumor’s clinical presentation and histological features, but on its molecular characteristics. In fact, our patient represents only the second such reported case, wherein, a molecularly confirmed IFS was noted to regress spontaneously.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression in a Patient With Infantile Fibrosarcoma

Danzer

Ramirez

LaQuaglia

et al. 2018

Journal of Pediatric Hematology/Oncology

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Infantile fibrosarcoma usually presents as a rapidly growing mass on the extremities or trunk. We describe spontaneous regression in a 5-month-old female infant with biopsy proven, molecularly confirmed, right leg infantile fibrosarcoma currently at 26 months of age with no signs of local recurrence. Previously reported cases of spontaneous regression are reviewed, suggesting a benign clinical course in some cases. Although evidence for spontaneous regression is anecdotal in this rare tumor type, physicians should weigh the risks and benefits of surgery and chemotherapy against watchful waiting.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Regression in a Patient With Infantile Fibrosarcoma

Danzer

Ramirez

LaQuaglia

et al. 2018

Journal of Pediatric Hematology/Oncology

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“…This behavior has been described in 3 different case reports. [25][26][27] The patient presented in this paper received a neoadjuvant chemotherapy followed by surgical marginal resection. The aim of the operation was to preserve the limb and prevent amputation which was opposed by the parents.…”

Section: Discussionmentioning

confidence: 99%

Marginal resection as a potential curative treatment option of infantile fibrosarcoma with good response after chemotherapy: A case report of an ETV6-NTRK3 positive infantile fibrosacroma of the distal tibia

2023

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Rationale: The infantile fibrosarcoma (IFS) is a non-rhabdomyosarcoma soft tissue sarcoma with locally aggressive properties. State of the art therapy consists of neoadjuvant chemotherapy followed by wide resection according to the criteria of the musculoskeletal tumor society. Diagnoses: An ETV6-NTRK3 positive IFS of the distal tibia in a 21-months old child showed good response to chemotherapy. Interventions: Due to refusal of amputation marginal resection completing the margins with a high speed drill and filling the space with bone cement was performed. Outcomes: At latest follow-up 10 years after surgery, no recurrence was observed. Lessons: An individual therapy for surgical treatment of IIFS is recommended. This comprises marginal resection in instead of the golden standard “wide resection” in selected cases.

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“…Apart from the cases presented, only three other case reports have been published. 7,8,16 Notably, in the EpSSG experience, of 50 patients with IFS, a wait-and see approach was used for four patients. Of these, three needed delayed chemotherapy for tumors that did not decrease in size.…”

Section: Agementioning

confidence: 99%