Spontaneous regression of hepatocellular carcinoma: a systematic review

Oquiñena, Susana; Guillén-Grima, Francisco; Iñarrairaegui, Mercedes; Zozaya, José Manuel; Sangro, Bruno

doi:10.1097/meg.0b013e328324b6a2

Cited by 71 publications

(53 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[7][8][9][10][11] Spontaneous tumor regression is rare, but with higher incidence of HCC compared to other cancers. 12 Two meta-analyses on spontaneous regression of primary HCC have been reported, however the mechanism of this phenomenon has not yet been identified. 12,13 Tumor hypoxia due to spontaneous hepatic artery thrombosis or rapid tumor growth, or inflammatory responses was suggested as possible mechanisms.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

Hwang

Lee

et al. 2015

Korean J Gastroenterol

View full text Add to dashboard Cite

The occurrence of hepatocellular carcinoma (HCC) is closely associated with viral hepatitis or alcoholic hepatitis. Although active surveillance is ongoing in Korea, advanced or metastatic HCC is found at initial presentation in many patients. Metastatic HCC presents with a hypervascular intrahepatic tumor and extrahepatic lesions such as lung or lymph node metastases. Cases of HCC presenting as carcinoma of unknown primary have been rarely reported. The authors experienced a case of metastatic HCC in a patient who presented with a metastatic bone lesion but no primary intrahepatic tumor. This case suggests that HCC should be considered as a differential diagnosis when evaluating the primary origin of metastatic carcinoma. (Korean J Gastroenterol 2015;66:50-54)

show abstract

Section: Discussionmentioning

confidence: 99%

“…12,13 Tumor hypoxia due to spontaneous hepatic artery thrombosis or rapid tumor growth, or inflammatory responses was suggested as possible mechanisms. 12,13 Approximately 85 spontaneous tumor regression cases have been reported, but only 8 cases had pathologic confirmation of microscopic viable cancer cells in suspicious hepatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

Hwang

Lee

et al. 2015

Korean J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The hypothesis for a key role of the immune system in combating cancer is further supported by clinical observations on spontaneous regressions of tumor in humans (Bodey, 2002;del Giudice et al, 2009;Oquiñena et al, 2009) and an increased risk of some cancer development in immunodeficient patients (Jagadeesh et al, 2012;Kubica & Brewer, 2012). It has also been shown that a presence of immune cell infiltrates in cancer tissues correlate with a better prognosis (Movassagh et al, 2004;Pagès et al, 2005;Wansom et al, 2012).…”

Section: Introductionmentioning

confidence: 91%

Breaking immunotolerance of tumors: A new perspective for dendritic cell therapy

Roliński¹,

Hus

2014

Journal of Immunotoxicology

View full text Add to dashboard Cite

The use of dendritic cells (DC) in cancer immunotherapy is based on their potent abilities to present antigens, so they can act as 'natural adjuvants' to enhance immunogenicity of tumor antigens and stimulate specific cytotoxic T-cells. Large amounts of DC can be generated from bone marrow, neonatal cord blood, and peripheral blood CD34 þ hematopoietic stem cells, or from peripheral blood monocytes. The DC can then be pulsed with tumor antigens and reinfused. In vitro, antigen-pulsed DC can stimulate allogeneic T-cell proliferation and induction of autologous specific cytotoxic T-cells; in vivo, the cells inhibit the growth of tumors or protect hosts (i.e. mice) from development of inoculated tumors. The results of preliminary clinical trials have shown that DC vaccines are safe and elicit immune responses; however, the rates of clinical responses are low. It has become quite clear that one key reason for unsatisfactory clinical results is tumor-induced immunosuppression. Among the factors contributing to this type of immunosuppression are populations of regulatory cells including: T-regulatory (T reg ) cells, myeloid-derived suppressor cells (MDSC), tumor-associated macrophages (TAM), and DC expressing 2,3-dioxygenase indoleamine (IDO-DC). This review presents an overview of the current understanding about populations of regulatory cells and the most current research efforts directed to overcome immunosuppressive activity due to the tumor microenvironment.

show abstract

“…This must be balanced against the observation that a previous HCC/VP patient survived for seven years after diagnosis; and the rare but reported incidence of spontaneous regression of HCC which is estimated at 0.4%. 21 …”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma in variegate porphyria: a case report and literature review

et al. 2014

View full text Add to dashboard Cite

Variegate porphyria is an autosomal dominant acute hepatic porphyria characterized by photosensitivity and acute neurovisceral attacks. Hepatocellular carcinoma has been described as a potential complication of variegate porphyria in case reports. We report a case of a 48-year-old woman who was diagnosed with hepatocellular carcinoma following a brief history of right upper quadrant pain which was preceded by a few months of blistering lesions in sun-exposed areas. She was biochemically diagnosed with variegate porphyria, and mutational analysis confirmed the presence of a heterozygous mutation in the protoporphyrinogen oxidase gene. Despite two hepatic resections, she developed pulmonary metastases. She responded remarkably well to Sorafenib and remains in remission 16 months after treatment. A review of the literature revealed that hepatocellular carcinoma in variegate porphyria has been described in at least eight cases. Retrospective and prospective cohort studies have suggested a plausible association between hepatocellular carcinoma and acute hepatic porphyrias. Hepatic porphyrias should be considered in the differential diagnoses of hepatocellular carcinoma of uncertain aetiology. Patients with known hepatic porphyrias may benefit from periodic monitoring for this complication.

show abstract

Spontaneous regression of hepatocellular carcinoma: a systematic review

Cited by 71 publications

References 16 publications

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm

Breaking immunotolerance of tumors: A new perspective for dendritic cell therapy

Hepatocellular carcinoma in variegate porphyria: a case report and literature review

Contact Info

Product

Resources

About