Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood

Bortolotti, Flavia; Guido, Maria; Cadrobbi, P; Crivellaro, Carlo; Bartolacci, S.; Gatta, Angelo

doi:10.1016/j.dld.2005.04.030

Cited by 21 publications

(9 citation statements)

References 17 publications

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“…Two patients remained asymptomatic, with a normal liver function and HBV DNA negative according to non-PCR tests throughout a follow-up of 16 and 17 years, respectively; one also lost HBsAg. As recently reported in detail, 32 liver biopsy in adulthood showed regression of the lesions of cirrhosis in both cases.…”

Section: Resultssupporting

confidence: 56%

Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study

et al. 2006

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Chronic hepatitis B is usually a benign disease in Caucasian children; however, the longterm prognosis remains unsettled. This report describes the results of a 29-year longitudinal study including 99 white children with chronic hepatitis B, mainly acquired horizontally: 91 were hepatitis B e antigen (HBeAg) positive (4 had cirrhosis), and 8 were HBeAg negative at presentation. Of the 91 HBeAg-positive children, 89 underwent HBeAg seroconversion after a mean period of 5.2 ؎ 4.0 years and were included in the study. Of the 85 children without cirrhosis, one had HBeAg-negative hepatitis and the other 84 became inactive carriers. During a mean follow-up of 14.5 ؎ 6.1 years after HBeAg seroclearance, 4 carriers experienced reactivation, and 3 of them had HBeAg-negative hepatitis at the last follow-up. Of the 8 initially HBeAg-negative children, 2 had HBeAg-negative hepatitis, and 6 were inactive carriers. Of the 4 children with cirrhosis, 2 had hepatocellular carcinoma (HCC) and remained alive and 2 lost the histological features of cirrhosis in adulthood. Two patients with HBeAg-negative hepatitis and 1 with cirrhosis had experienced drug abuse. At the end of follow-up, 15 of the 89 initially HBeAg-positive patients and 2 of 8 initially HBeAg-negative children had cleared hepatitis B surface antigen. In conclusion, the overall prognosis for chronic hepatitis B in horizontally infected Caucasian children is favorable; however, some patients progress to HCC and HBeAg-negative hepatitis. Long-term monitoring is important, as is counseling on cofactors of liver damage, such as alcohol and drug abuse. (HEPATOLOGY 2006;43:556-562.)

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Section: Resultssupporting

confidence: 56%

Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study

et al. 2006

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“…In longitudinal studies progression of chronic hepatitis B to cirrhosis was not observed over a period up to 29 years [13][14][15]. Reversion of cirrhosis to significant fibrosis [13] or even to near normal liver in adulthood [16] has been reported in few cases with well-compensated liver disease. HCC is also a rare complication affecting cirrhotic males.…”

Section: Disease Progressionmentioning

confidence: 96%

Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors

Fattovich

Bortolotti

Donato

2008

Journal of Hepatology

1,150

1,015

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“…Because the goal of treatment is to stop ongoing necroinflammation and prevent progression to cirrhosis and HCC, follow‐up biopsies may be helpful, at least in protocol settings, if not in community practice. Liver fibrogenesis is an active, dynamic process that may progress as well as regress spontaneously or after therapy 25, 26. Reversal is a slow process taking years and may only occur if the patient becomes immune‐tolerant or if the virus is eliminated.…”

Section: Grading and Stagingmentioning

confidence: 99%

Liver biopsy findings in chronic hepatitis B

2009

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Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood

Cited by 21 publications

References 17 publications

Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study

Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study

Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors

Liver biopsy findings in chronic hepatitis B

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