Spontaneous regression of congenital cystic adenomatoid malformation of the lung: Longitudinal examinations by magnetic resonance imaging

Abstract

We report a case of large cystic adenomatoid malformation of the lung (CCAM), which occupied almost the entire left lung with a prominent mediastinal shift at 24 weeks of gestation. The volume of the lesion, determined by magnetic resonance imaging (MRI), was 27.0 cm3. Subsequent MRI and ultrasound examinations revealed a spontaneous resolution of the lesion at 32 and 36 weeks of gestation without a mediastinal shift, when the lesion volume was 12.8 cm3 and 5.6 cm3, respectively. At 37 weeks of gestation, a mature male baby weighing 2638 g with an Apgar score of 7 was delivered by elective cesarean section. A lobectomy of the left upper lobe of the lung was carried out at 3 days of age, due to an enlargement of the CCAM after birth.

Large fetal congenital cystic adenomatoid malformations: growth trends and patient survival

“…Most large CCAMs grow initially in size but are usually followed by a period of significant regression, both in absolute and relative terms, by the start of the third trimester. The overall growth patterns observed in our series appear to be similar to that of most CCAMs in general as reported by others [10,16]. As a result, we recommend frequent serial observation by ultrasound imaging for all large CCAMs until at least 30 weeks' gestation.…”

Percutaneous laser ablation under ultrasound guidance for fetal hyperechogenic microcystic lung lesions with hydrops: a single center cohort and a literature review

“…Complete, spontaneous regression of congenital lung lesions has been reported, but not in cases with hydrops (without prenatal treatment). 47,48 Langer et al 49 reported cases of spontaneous regression of BPS, but only one had ascites and 'diffuse' subcutaneous edema at 20 weeks in which 500 ml of ascites was drained. At 24 weeks, the fetus had significant recurrent hydrops.…”