Spontaneous regression of an abdominal aortic aneurysm in an immunocompromised patient

Bellows, Patricia H.; Anaya‐Ayala, Javier E.; Younes, Houssam K.; Charlton-Ouw, Kristofer M.; Bismuth, Jean; Peden, Eric K.

doi:10.1177/1358863x10375331

Cited by 9 publications

(9 citation statements)

References 12 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aneurysmal dilatation of ascending aorta due to pseudoxanthoma elasticum like syndrome in a patient with beta thalassemia intermedia has been reported [10]. Spontaneous regression of an abdominal aortic aneurysm in an immunocompromised patient has been documented [11].…”

Section: Discussionmentioning

confidence: 97%

Unusual Presentation of HIV Vasculopathy in a Child

Munirathnam

Raj

2011

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

The manifestations of human immunodeficiency virus (HIV) infection are protean and vasculopathy is an uncommon but important complication. A large-vessel (aorta and femoral and carotid arteries) vasculopathy is rarely described in children. We describe a HIV positive thalassaemic child who developed multiple aneurysms in abdominal aorta. HIV vasculopathy resulted in severe aortoarteritis and was fatal in this child.

show abstract

Section: Discussionmentioning

confidence: 97%

Unusual Presentation of HIV Vasculopathy in a Child

Munirathnam

Raj

2011

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

show abstract

“…Development of aneurysms in HIV-positive patients may occur in a variety of different manners: as a result of direct action of the virus on the aorta wall, triggering an inflammatory process; bacterial infections of aorta with prior degeneration, characterizing a mycotic aneurysm; or degeneration of the aorta wall, resulting in atherosclerotic aneurysms, the appearance of which may be anticipated by changes to lipid metabolism caused by antiretroviral therapy [9,10] . Aneurysmal disease provoked by HIV is a distinct clinical entity, with no well-defined etiology, and which generally affects younger patients without risk factors for atherosclerotic disease [9] .…”

Section: Discussionmentioning

confidence: 99%

“…Aneurysmal disease provoked by HIV is a distinct clinical entity, with no well-defined etiology, and which generally affects younger patients without risk factors for atherosclerotic disease [9] . It is generally associated with a reduction in CD4 levels and it can lead to adventitial damage and injury to the vasa vasorum by HIV [9,10] . These aneurysms are saccular and are found in atypical sites, tending to be multiple, with carotid and femoral arteries the most frequently involved [8,10] .…”

Section: Discussionmentioning

confidence: 99%

“…It is generally associated with a reduction in CD4 levels and it can lead to adventitial damage and injury to the vasa vasorum by HIV [9,10] . These aneurysms are saccular and are found in atypical sites, tending to be multiple, with carotid and femoral arteries the most frequently involved [8,10] . Surgical treatment of patients with aneurysmal disease related to HIV has achieved limited results.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of these patients were treated with open surgery and the perioperative mortality rate was 9% [11] . In some cases, aneurysms may be associated with infectious processes, of which salmonella, tuberculosis and Haemophilus influenzae are the most frequent causes [9,10] .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Thoracoabdominal Aortic Aneurysm in a HIV-positive Patient

Lucas¹,

Binotto²,

Behar³

et al. 2017

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Advent of antiretroviral therapy has increased survival of patients with human immunodeficiency virus (HIV) infections, with the result that some of these patients now develop degenerative diseases, such as atherosclerotic aneurysms. Degenerative thoracoabdominal aortic aneurysm is rare in HIV patients. In this report, a 63-year-old male patient with HIV submitted to open repair of thoracoabdominal aortic aneurysm. The patient did not suffer any type of complication in the perioperative period and remained well in a 28-month follow-up period. In summary, open repair still remains a good alternative for aortic complex aneurysms even in HIV patients.

show abstract

Evaluating Growth Patterns of Abdominal Aortic Aneurysm Diameter With Serial Computed Tomography Surveillance

et al. 2021

View full text Add to dashboard Cite

IMPORTANCE Small abdominal aortic aneurysms (AAAs) are common in the elderly population. Their growth rates and patterns, which drive clinical surveillance, are widely disputed.OBJECTIVE To assess the growth patterns and rates of AAAs as documented on serial computed tomography (CT) scans. DESIGN, SETTING, AND PARTICIPANTSCohort study and secondary analysis of the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA 3 CT), a randomized, double-blind placebo-controlled clinical trial conducted from 2013 to 2018, with CT imaging every 6 months for 2 years. The trial was a multicenter, observational secondary analysis, not related to treatment hypotheses of data collected in the N-TA 3 CT. Participants included 254 patients with baseline AAA diameter between 3.5 and 5.0 cm. EXPOSURES Patients received serial CT scan measurements, analyzed for maximum transverse diameter, at 6-month intervals. MAIN OUTCOMES AND MEASURESThe primary study outcome was AAA annual growth rate. Secondary analyses included characterizing AAA growth patterns, assessing likelihood of AAA diameter to exceed sex-specific intervention thresholds over 2 years.RESULTS A total of 254 patients, 35 women with baseline AAA diameter 3.5 to 4.5 cm and 219 men with baseline diameter 3.5 to 5.0 cm, were included. Yearly growth rates of AAA diameters were a median of 0.17 cm/y (interquartile range [IQR], 0.16) and a mean (SD), 0.19 (0.14) cm/y. Ten percent of AAAs displayed minimal to no growth (<0.05 cm/y), 62% displayed low growth (0.05-0.25 cm/y), and 28% displayed high growth (>0.25 cm/y). Baseline AAA diameter accounted for 5.4% of variance of growth rate (P < .001; R 2 , 0.054). Most AAAs displayed linear growth (70%); large variations in interval growth rates occurred infrequently (3% staccato growth and 4% exponential growth); and some patients' growth patterns were not clearly classifiable (23% indeterminate). No patients with a maximum transverse diameter less than 4.25 cm exceeded sex-specific repair thresholds at 2 years (men, 0 of 92; 95% CI, 0.00-0.055; women, 0 of 25 ; 95% CI, 0.00-0.247). Twenty-six percent of patients with a maximum transverse diameter of at least 4.25 cm exceeded sex-specific repair thresholds at 2 years (n = 12 of 83 men with diameter ranging from 4.25 to <4.75 cm; 95% CI, 0.091-0.264; n = 21 of 44 men with diameter ranging from 4.75-5.0 cm; 95% CI, 0.362-0.669; n = 3 of 10 women with diameter Ն4.25 cm; 95% CI, 0.093-0.726).CONCLUSIONS AND RELEVANCE Most small AAAs showed linear growth; large intrapatient variations in interval growth rates were infrequently observed over 2 years. Linear growth modeling of AAAs in individual patients suggests smaller AAAs (<4.25 cm) can be followed up with a CT scan in at least 2 years with little chance of exceeding interventional thresholds.

show abstract

Spontaneous regression of an abdominal aortic aneurysm in an immunocompromised patient

Cited by 9 publications

References 12 publications

Unusual Presentation of HIV Vasculopathy in a Child

Unusual Presentation of HIV Vasculopathy in a Child

Thoracoabdominal Aortic Aneurysm in a HIV-positive Patient

Evaluating Growth Patterns of Abdominal Aortic Aneurysm Diameter With Serial Computed Tomography Surveillance

Contact Info

Product

Resources

About