“…The initial differential was broad and included ITP, thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, hemolytic uremic syndrome, hemophilia, septic or inflammatory arthritis, bursitis, intra-articular venous malformations, or trauma. 7,9,13 Upon reflection, a unifying explanation for the presentation is Lyme disease with resultant inflammatory arthritis and severe thrombocytopenia as causative of the hemarthrosis. The initial symptom improvement was thought to be due to the anti-inflammatory effects of the steroid regimen without treatment of additional underlying disease.…”