Spontaneous pyogenic vertebral osteomyelitis and endocarditis: Incidence, risk factors, and outcome

Pigrau, Carlos; Almirante, Benito; Flores, Xavier; Falcó, Vicenç; Rodríguez, Dolors; Gasser, I; Villanueva, Carmen Navarro; Pahissa, Albert

doi:10.1016/j.amjmed.2005.02.027

Cited by 190 publications

(131 citation statements)

References 31 publications

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“…In our experience, 14.6 % (19/130) of spontaneous vertebral osteomyelitis infections (Pott's disease) were caused by M. tuberculosis [54]. In other studies, 17-27 % of all spondylodiscitis cases had a mycobacterial etiology [8,44,66].…”

Section: Tuberculous Vertebral Osteomyelitis (Pott's Disease)mentioning

confidence: 58%

“…Although blood cultures are often negative in BS [9] and agglutination titers may be low (especially in patients with prolonged disease), the anti-Brucella Coombs test shows high titers and easily excludes the diagnosis of BS. The differential diagnosis with PS is more difficult since blood cultures are negative in 30-40 % of PS cases [54,69] and CT-guided or open biopsy cultures have a diagnostic yield of 77 % [49]. In TS, the diagnostic yield of CT-guided biopsy and mycobacterial culture is around 75 % [11,44,49,52].…”

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

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Bone and joint tuberculosis

2012

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Section: Tuberculous Vertebral Osteomyelitis (Pott's Disease)mentioning

confidence: 58%

Section: Diagnosis and Differential Diagnosismentioning

confidence: 99%

Bone and joint tuberculosis

2012

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“…Some researchers have reported that the rising of MRSA strains has been responsible for an increase in the action of Staphylococcus genus as IE causing agent. On the other hand, the participation of Streptococcus genus in IE etiology has decreased (Ako et al, 2003;Pigrau et al, 2005;Ferreiros et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of beta-pinene, alpha-pinene and eugenol on the growth of potential infectious endocarditis causing Gram-positive bacteria

Leite¹,

Lima²,

Souza³

et al. 2007

Rev. Bras. Cienc. Farm.

184

119

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“…Endocarditis is diagnosed in up to a third of reported cases proving the necessity of careful examination for infective endocarditis under the existence of pyogenic vertebral osteomyelitis 19) . There are no data from controlled trials that suggest the optimal duration of therapy.…”

Section: Discussionmentioning

confidence: 99%

Investigations of Hospitalized Cases of Pyogenic Vertebral Osteomyelitis

Nishisako

Kunishima

Shimizu

et al. 2015

J St. Marianna Univ

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Pyogenic vertebral osteomyelitis is difficult to diagnose and treat. The duration of antibiotic therapy, the administration of treatment, and several other factors regarding pyogenic vertebral osteomyelitis remain controversial. The aim of this investigation was to examine its diagnosis and treatment and consider possible solutions. This was a retrospective study of 11 cases of hospitalized patients with pyogenic vertebral osteomyelitis, including their diagnosis, treatment, and other factors. The diagnosis of vertebral osteomyelitis was confirmed with the combination of imaging and biological evidence. The Erythrocyte Sedimentation Rate (ESR) level served as an index to determine the duration of therapy. The duration from symptom onset to diagnosis was 3-63 (median 10) days. Rate of positive blood cultures were obtained in 8 cases (72.7%). The most frequent comorbidity was infective endocarditis in 4 cases (36.6%). Affected vertebrae were lumber spine in 9 cases (81.8%) and multiple level involvement in 8 cases (72.7%). The mean duration of antibiotic therapy was 69.6 ± 17.9 days, with no recurrence. Patients diagnosed with pyogenic vertebral osteomyelitis require careful examination for infective endocarditis. Lumber level and multiple level involvement were more frequent than had previously been reported. Based on our experience, C-reactive Protein (CRP) is more useful than ESR as an index to evaluate the clinical response to therapy and may help determine the duration of treatment. It is important for general physicians to monitor vertebral osteomyelitis properly and provide an appropriate diagnosis and treatment.

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Spontaneous pyogenic vertebral osteomyelitis and endocarditis: Incidence, risk factors, and outcome

Cited by 190 publications

References 31 publications

Bone and joint tuberculosis

Bone and joint tuberculosis

Inhibitory effect of beta-pinene, alpha-pinene and eugenol on the growth of potential infectious endocarditis causing Gram-positive bacteria

Investigations of Hospitalized Cases of Pyogenic Vertebral Osteomyelitis

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