Spontaneous pneumothorax in young subjects: A clinical and pathological study

Lichter, Ivan; Gwynne, J. F.

doi:10.1136/thx.26.4.409

Cited by 116 publications

(46 citation statements)

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“…Analysis of this group revealed it to be composed predominantly, but not solely, of young men. This is a similar group to those identified on clinical grounds by Lichter and Gwynne, 8 who also identified 2 young women in their group.…”

Section: Commentmentioning

confidence: 57%

“…The fibroblastic foci play a similar role in their use in recognizing usual interstitial pneumonia, where again, they are not pathognomonic for usual interstitial pneumonia but are a wellrecognized, morphologic feature. 13,14 Although the key features of PAFL (zonation, fibroblastic foci, and wedge-shaped configuration) were not recognized by Lichter and Gwynne, 8 one of their photographs is suggestive of a PAFL lesion. Of course they, like others, were struck by the clinicopathologic presentation of the cases and hypothesized a ''nonspecific,'' infectious etiology abetted by ''some local inherent predisposition.''…”

Section: Commentmentioning

confidence: 99%

“…Using as a guideline the morphologic features found in previous reviews of SP, [8][9][10][11][12] each case was evaluated for reactive eosinophilic pleuritis, elastosis, pleural fibrosis, emphysema, intra-alveolar macrophages, cholesterol clefts, vasculopathy, intraparenchymal or intrapleural cysts, and underlying disorders, such as lymphangioleiomyomatosis, infection, malignancy, or endometriosis. In addition, the presence or absence of fibroblastic foci, a feature not identified in prior reviews of cases of pneumothorax, was added.…”

Section: Methodsmentioning

confidence: 99%

“…However, that is also a feature believed to represent a nonspecific reaction to a pneumothorax. 7,8 Identifying the underlying disorder may carry important clinical ramifications, exemplified by the development of renal tumors in Birt-Hogg-Dubé syndrome and aortic root dissection in patients with Marfan syndrome. With this in mind, we conducted a multicenter, 10-year, retrospective review of all cases of SP with the hope of identifying and correlating histopathologic patterns with specific clinical entities.…”

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confidence: 99%

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A Unique, Histopathologic Lesion in a Subset of Patients With Spontaneous Pneumothorax

Belchis

Shekitka

Gocke

2012

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Spontaneous pneumothorax can be idiopathic (primary), or it can occur in association with an underlying predisposing condition (secondary). Spontaneous pneumothorax may be a harbinger of an undiagnosed clinical condition, which may be associated with serious systemic abnormalities, making early recognition and diagnosis important. The pulmonary pathology of some of these disorders has not been fully elucidated.Objective.-To review cases of pneumothorax in the hope of identifying pathologic features that might correlate to specific clinical syndromes.Design.-The pathology computer files at 3 hospitals were searched for all cases of spontaneous pneumothorax, primary and secondary, regardless of etiology during a 11-year period. Ninety-two cases were retrieved. Each of the cases was evaluated for reactive eosinophilic pleuritis, elastosis, pleural fibrosis, emphysema, intra-alveolar macrophages, cholesterol clefts, vasculopathy, and intraparenchymal or intrapleural cysts. Clinical information regarding asthma and smoking history, site of the pneumothorax, family history, radiographic findings, predisposing conditions, recurrence, age, and sex were extracted from the medical records.Results.-In 11 patients (12% of all the patients with spontaneous pneumothorax), a distinctive pattern of pleural fibrosis with islands of fibroblastic foci within a myxoid stroma was noted at the pleural-parenchymal interface or leading edge. These lesions correlated with a select subset of patients, consisting predominantly of young men.Conclusions.-Our review identified a distinct pattern of pneumothorax-associated fibroblastic lesions in a subset of cases of spontaneous pneumothorax. Whether this is related to the pathogenesis of the pneumothorax remains to be elucidated.

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Section: Commentmentioning

confidence: 57%

Section: Commentmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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A Unique, Histopathologic Lesion in a Subset of Patients With Spontaneous Pneumothorax

Belchis

Shekitka

Gocke

2012

Archives of Pathology &Amp; Laboratory Medicine

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“…Primer spontan pnömoto-raksa (PSP) en sık genç, uzun boylu, sigara içen, zayıf erkeklerde rastlanır. [1,2] Sigara alışkanlığı olmayan spontan pnömo-torakslı hastalarda yüksek sıklıkla bronşiyal anomaliler görül-mektedir. PSP'nin yıllık insidansı erkeklerde 18-28/100.000, kadınlarda 1.2-6/100.000'dir.…”

Section: Introductionunclassified

Spontaneous Pneumothorax Treatment Modalities: A Study of 48 Cases

et al. 2011

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ÖZET AmaçSpontan pnömotoraks akciğer ile göğüs duvarı arasında serbest hava toplanmasıdır. Tanısı klinik ve/veya radyolojik olarak konur. Tedavi yaklaşımları açısından farklı uygulamalar mevcuttur. Bu ça-lışmada, pnömotoraks ve tedavi seçenekleri üzerindeki klinik tecrü-belerimizi literatür bilgileri eşliğinde tartıştık. Gereç ve YöntemKliniğimize başvuran 48 spontan pnömotoraks olgusu prospektif olarak değerlendirildi. Çalışmamıza primer spontan pnömotoraks olguları dahil edildi. Olgular yaş, cinsiyet, ek hastalıklar, semptomlar, cerrahi yöntemler ve takip açısından değerlendirildi. BulgularYirmi olgu (%41.7) total pnömotoraks, 28 olgu (%58.3) parsiyel pnö-motoraks idi. Otuz bir (%64.6) olgu ilk pnömotoraks iken 17 (%35.4) olgu nüks pnömotoraks idi; 26 (%54.2) sol, 22 (%45.8) sağ pnömo-toraks mevcuttu. Spontan pnömotoraks tedavi yöntemleri arasında farklı uygulamalar mevcuttur. Olguların 38'i yalnızca tüp torakostomi, 5'i plöredez ve 6'sı bül ligasyonu ile tedavi edildi. SonuçSpontan pnömotoraks tedavisindeki amaç nüksü önlemek olmalı-dır. Tüp torakostomiye ilave olarak plöredez ve gerekli durumlarda cerrahi tedavi gündeme gelir. Hastanede kalış süresini kısalt-mak, hastanın konforunu arttırıcı yaklaşımları tercih etmek önemli-dir. Nüks pnömotoraks tedavisinde tüp torakostomiye ek olarak bir plöredez veya plörektomi prosedürü mutlaka uygulanmalıdır.Anahtar sözcükler: Bül ligasyonu; plöredez; spontan pnömotoraks. SUMMARY Objectives Spontaneous pneumothorax is defined as the collection of free air between the lung and chest wall, and is diagnosed clinically and radiologically. Treatment approaches to this condition are variable. In our study, we discussed our experience on pneumothorax and its treatment options in light of relevant literature. Methods patients with spontaneous

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Pneumothorax

Seaton¹

2000

Crofton and Douglas's Respiratory Diseases

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Spontaneous pneumothorax in young subjects: A clinical and pathological study

Cited by 116 publications

References 13 publications

A Unique, Histopathologic Lesion in a Subset of Patients With Spontaneous Pneumothorax

A Unique, Histopathologic Lesion in a Subset of Patients With Spontaneous Pneumothorax

Spontaneous Pneumothorax Treatment Modalities: A Study of 48 Cases

Pneumothorax

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