Spontaneous Pneumothorax as the Initial Manifestation of Medullary Thyroid Carcinoma

Spontaneous pneumothorax as the initial manifestation of stage IBprimary pulmonary carcinoma: Really early stage cancer?

“…However, it still can be the first clinical manifestation of pulmonary cancers in few case. [2,[12][13][14][15] The mechanism producing pneumothorax from pulmonary cancer is not well elucidated, but several theories have been advanced. One is that necrosis of the cancer directly ruptured into the pleural space.…”

Spontaneous Pneumothorax as the Initial Presentation in an Osteosarcoma Patient: A Case Report

“…[1,[7][8][9] Many sporadic case reports also describe SP due to lung metastases from angiosarcoma, metastatic thyroid (papillary, medullary) carcinoma, teratomas, Wilms' tumors, melanomas, carcinomas of the kidney and pancreas, metastatic ovarian granulosa cell tumor, testicular cancer, lymphomas, choriocarcinomas, and lymphangiomatosis. [6,[13][14][15][16] Sensitivity of detection of lung metastasis was 57% by chest x-ray and 88% by chest computed tomography. [8] Chest X-ray upright PA view is not 100% sensitive in diagnosing pneumothorax.…”

“…There is a known association between emphysematous pulmonary bullae and lung cancer, but this very rarely predisposes to pneumothorax as the initial clinical manifestation, 0.03% being the incidence due to the primary lung tumour and with that of pulmonary metastases is even rarer. [5,6] Lung is the most frequent site for metastasis of osteosarcoma. [7,8] The mechanism of pneumothorax is not clearly understood yet, several hypotheses have been proposed [1] : (1) Formation of a fistula between parenchyma and pleura due to rupture of necroticsubpleural tumor nodule or micrometastasis, secondary to vascular lesion or chemotherapy or radiotherapy.…”