Spontaneous perirenal hemorrhage (Wunderlich syndrome): An analysis of 28 cases

Kim, Jong Wook; Kim, Jung Youn; Ahn, Sun Tae; Park, Tae Yong; Oh, Mi Mi; Moon, Du Geon; Park, Hong Seok

doi:10.1016/j.ajem.2018.04.045

Cited by 46 publications

(61 citation statements)

References 15 publications

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“…10,11 Over 90% of renal AMLs are discovered incidentally on imaging, though some patients may present with Wunderlich syndrome, spontaneous, nontraumatic hemorrhage into the perinephric space characterized by the triad of flank pain, flank mass, and hypovolemic shock. 11,12 Spontaneous rupture has also been associated with coagulopathic states such as pregnancy. [13][14][15] A statement of causality cannot be made from a single incident of a ruptured renal AML rupture following a COVID-19 infection, though the timing is notable.…”

Section: Discussionmentioning

confidence: 99%

Renal angiomyolipoma rupture in a young female with COVID-19

Young

Kalczynski

Emerling

et al. 2021

The American Journal of Emergency Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Renal angiomyolipoma rupture in a young female with COVID-19

Young

Kalczynski

Emerling

et al. 2021

The American Journal of Emergency Medicine

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“…In a series of 165 patients with WS, Zhang et al observed that renal neoplasm was the most common cause, with angiomyolipoma being the most common neoplasm 4 . There are only scant reports of renal sarcomas presenting with primarily as WS 5, 6 .…”

Section: Discussionmentioning

confidence: 99%

Case Report: Partial nephrectomy in primary renal sarcoma presenting as Wunderlich syndrome; a rare tumour with rare presentation managed atypically

et al. 2019

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Spontaneous retroperitoneal haemorrhage also called Wunderlich Syndrome (WS) may be caused by various aetiologies. One of the most common causes is renal tumour. Renal sarcoma is a rare cause of WS, and renal sarcoma in itself is a rare entity. In the era of nephron-sparing surgery, optimum management of primary renal sarcoma remains a dilemma as there are limited number of cases available in the literature. Nevertheless, radical nephrectomy remains the recommended treatment, keeping in mind the aggressiveness of the tumour. We report a case of primary undifferentiated renal sarcoma, which presented as WS, and which was managed by partial nephrectomy.

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“…All three of these features occur concomitantly in only about 20% of cases. Haematuria is also common but not always present [1][2][3]. Renal neoplasms specifically angiomyolipoma which is a benign neoplasm accounts for 60-65% cases of WS.…”

Section: Introductionmentioning

confidence: 99%

“…Wunderlich syndrome (WS), initially described by Wunderlich in 1856, is a rare syndrome of spontaneous nontraumatic bleeding in the perinephric space which is subcapsular and retroperitoneal in location [ 1 , 2 ]. It is usually associated with the Lenk’s triad which comprises acute flank pain, palpable flank mass and hypovolemic shock.…”

Section: Introductionmentioning

confidence: 99%

“…Renal neoplasms specifically angiomyolipoma which is a benign neoplasm accounts for 60–65% cases of WS. Other aetiologies include renal cell carcinoma (RCC), vasculitis such as polyarteritis nodosa (PAN) pheochromocytoma and other retroperitoneal tumours [ 1 , 2 , 4 ]. Incidence of WS in pregnancy is extremely rare and there is no clear guidance on how to manage it and it often requires a collaborative approach of several specialists such as obstetricians, internists and urologists [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Post-partum occurrence of Wunderlich syndrome and microangiopathic haemolytic anaemia (MAHA): a case report

Swaminathan

Sedhom

Shahzad

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

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This is a case of a 27-year-old primigravida with monochorionic diamniotic twin gestation who was admitted to the hospital for induction of labour. Her postpartum course was complicated by microangiopathic haemolytic anemia (MAHA). The etiology for the MAHA was initially thought to be secondary to pre-eclampsia and vitamin B12/folate deficiency. However, she had persistent anemia and further workup demonstrated that she had a left renal cell carcinoma (RCC) with perinephric haemorrhage consistent with Wunderlich syndrome. This case was intriguing because of its unusual presentation and the several diagnostic and therapeutic challenges along the way.

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Spontaneous perirenal hemorrhage (Wunderlich syndrome): An analysis of 28 cases

Cited by 46 publications

References 15 publications

Renal angiomyolipoma rupture in a young female with COVID-19

Renal angiomyolipoma rupture in a young female with COVID-19

Case Report: Partial nephrectomy in primary renal sarcoma presenting as Wunderlich syndrome; a rare tumour with rare presentation managed atypically

Post-partum occurrence of Wunderlich syndrome and microangiopathic haemolytic anaemia (MAHA): a case report

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