Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (<i>Colobus guereza kikuyuensis</i>)

Hobson, David J; Turner, Patricia V.

doi:10.1111/j.1600-0684.2007.00259.x

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Hobson and Turner [ 56 ] reported a case of a 12-year-old male colobus monkey ( Colobus guereza kikuyuensis ) with a slowly progressive ataxia and paresis which resulted in an acute episode of recumbency, depression, and seizures. Necropsy revealed an 8 cm diameter mass, adherent to the serosa of the proximal duodenum and colon, and embedded within the pancreas and mesenteric root.…”

Section: Pancreasmentioning

confidence: 99%

Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review

Bakker

Garza²

2022

Animals

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Literature concerning veterinary medicine of non-human primates is continuously updated, yet endocrine disorders remain underreported. While case or survey reports of individual endocrinopathies are available, a comprehensive review is not. An exhaustive literature search on this subject via widely used academic search systems, (e.g., Google Scholar, PubMed, BioOne complete and Web of Science), and peer-reviewed publications, proceedings, and newsletters was performed. Selected major endocrine entities will be described with emphasis on clinical signs, morphologic appearances, concomitant diseases, as well as available treatment options. Mostly, no clinical signs were noted and on gross pathology, the endocrine organs were unremarkable. An endocrine-related diagnosis was frequently made as an incidental finding after standard histopathological examination. During the review, the pancreas represented the most affected endocrine organ and diabetes mellitus represented the most clinically significant disorder. Currently, no standard procedure for diagnosing, monitoring, or treating endocrine disorders in non-human primates exists.

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Section: Pancreasmentioning

confidence: 99%

Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review

Bakker

Garza²

2022

Animals

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“…Baboons have been used for experimental studies affecting the endocrine system, including studies directly affecting the endocrine pancreas . Previous studies have documented the occurrence of pancreatic endocrine tumors in macaques and chimpanzees , owl monkey , colobus monkey , and baboons , with an incidence as high as 4.6% of all baboon tumors in one study , but the pathologic features of pancreatic endocrine neoplasms in Papio spp. have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic neuroendocrine tumors in twelve baboons (Papio spp.)

Owston

LaRue

Dick

et al. 2016

J of Medical Primatology

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Background Pancreatic neuroendocrine tumors (PNETs) are rare in nonhuman primates and in humans. Methods Twenty-one PNETs from twelve female baboons (Papio spp.) from the Southwest National Primate Research Center were evaluated using histopathology and immunohistochemistry. Results Histologically, all tumors were benign and had neuroendocrine packeting. Immunohistochemical staining for synaptophysin and chromogranin was positive in all tumors evaluated (17/17). Insulin was positive in 16/21 tumors. Somatostatin was positive in 9/20 tumors. Multifocal staining for glucagon and pancreatic polypeptide was evident in a minority of tumors (6/20 and 2/17, respectively). Gastrin and vasoactive intestinal peptide were negative in all tumors evaluated. Nine tumors expressed more than one hormone marker. Conclusions This is the first detailed pathologic study of pancreatic endocrine tumors in the baboon. The findings suggest that these tumors are generally benign and have similar morphologic and immunohistochemical features as those described in people, including the ability to express multiple hormones.

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“…In nonhuman primates, islet cell tumors of the pancreas appear to have a very low incidence with only a few cases reported in rhesus monkeys (McClure and Chandler 1982), and single reports in a pig-tailed macaque (McClure and Chandler, 1982), a marmoset (Dias et al ., 1996) and a colobus monkey (Hobson and Turner, 2008). Compared to pancreatic adenocarcinomas, islet cell tumors grow at a much slower rate, can produce large amounts of specific hormones with associated dramatic clinical signs, and, in humans, can arise from familial genetic mutations (Batcher et al ., 2011).…”

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confidence: 99%

Pancreatic Endocrine Tumour with Disseminated Pulmonary Thromboembolism in an Owl Monkey (Aotus nancymae)

Gozalo

Zerfas

Starost

et al. 2013

Journal of Comparative Pathology

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Summary Pulmonary thromboembolism associated with pancreatic endocrine neoplasia is extremely uncommon in humans and animals. Post mortem examination of an adult owl monkey revealed extensive pulmonary arterial thromboembolism and a well-demarcated mass attached to the pancreas. Histologically, the mass consisted of areas of interstitial fibrosis with loss of acini and islets and replaced by nests and sheets of polygonal cells with amphophilic cytoplasm, an eccentric rounded nucleus with stippled chromatin, and in some cells, with a single prominent eccentric nucleolus. Clusters of these cells were noted within vessels and adjacent lymph nodes. The cells did not stain with S-100 and insulin, stained rare individual cells with glucagon and somatostatin, but strongly stained with SP-1 Chromogranin. A few cells in pulmonary thrombi/emboli and adjacent lymph node stained also with SP-1 Chromogranin. Based on cell morphology, location, and immunohistochemical staining, the tumor was classified as pancreatic endocrine (islet cell) carcinoma with metastasis to regional lymph nodes and lung.

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Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis)

Cited by 6 publications

References 4 publications

Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review

Naturally Occurring Endocrine Disorders in Non-Human Primates: A Comprehensive Review

Pancreatic neuroendocrine tumors in twelve baboons (Papio spp.)

Pancreatic Endocrine Tumour with Disseminated Pulmonary Thromboembolism in an Owl Monkey (Aotus nancymae)

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